DE60124895D1 - Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate - Google Patents
Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten GranulateInfo
- Publication number
- DE60124895D1 DE60124895D1 DE60124895T DE60124895T DE60124895D1 DE 60124895 D1 DE60124895 D1 DE 60124895D1 DE 60124895 T DE60124895 T DE 60124895T DE 60124895 T DE60124895 T DE 60124895T DE 60124895 D1 DE60124895 D1 DE 60124895D1
- Authority
- DE
- Germany
- Prior art keywords
- granules
- coated
- group
- allylamines
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008187 granular material Substances 0.000 title abstract 4
- 150000003939 benzylamines Chemical class 0.000 title 1
- 239000007931 coated granule Substances 0.000 title 1
- 239000007919 dispersible tablet Substances 0.000 title 1
- 210000000214 mouth Anatomy 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000002543 antimycotic Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000002216 antistatic agent Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000008119 colloidal silica Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000013081 microcrystal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008191 permeabilizing agent Substances 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01402027A EP1279402B1 (de) | 2001-07-26 | 2001-07-26 | Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60124895D1 true DE60124895D1 (de) | 2007-01-11 |
Family
ID=8182825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60124895T Expired - Lifetime DE60124895D1 (de) | 2001-07-26 | 2001-07-26 | Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040220276A1 (de) |
| EP (1) | EP1279402B1 (de) |
| JP (1) | JP2005503366A (de) |
| AT (1) | ATE346590T1 (de) |
| DE (1) | DE60124895D1 (de) |
| WO (1) | WO2003009830A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002002081A1 (en) * | 2000-07-05 | 2002-01-10 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| CN100588390C (zh) * | 2003-01-30 | 2010-02-10 | 埃迪制药公司 | 掩蔽味道的包衣颗粒、其制备方法和含有所述包衣颗粒的口腔分散片 |
| ATE444731T1 (de) * | 2003-01-30 | 2009-10-15 | Ethypharm Sa | Geschmacksmaskierte beschichtete teilchen, verfahren zur herstellung und in der mundhöhle dispergierbare tabletten enthaltend die beschichteten teilchen |
| FR2850577B1 (fr) | 2003-02-03 | 2005-04-15 | Ethypharm Sa | Particules enrobees a gout masque, leur procede de preparation et comprimes orodispersibles contenant lesdites particules |
| AU2004246837B2 (en) * | 2003-06-06 | 2009-07-16 | Ethypharm | Orally-dispersible multilayer tablet |
| FR2855756B1 (fr) * | 2003-06-06 | 2005-08-26 | Ethypharm Sa | Comprime orodispersible multicouche |
| PT1729797E (pt) | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
| EP1621187A1 (de) * | 2004-07-26 | 2006-02-01 | AstraZeneca AB | Pharmazeutische multipartikuläre Tablettenzubereitungen und Prozess zu ihrer Herstellung |
| EP1913138B1 (de) | 2005-07-29 | 2016-08-24 | Abbott Laboratories GmbH | Verfahren zur herstellung von pankreatin-pulver mit einem niedrigen virusgehalt |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US20100015221A1 (en) * | 2005-12-20 | 2010-01-21 | Eisai R&D Management Co.Ltd. | Orally rapid disintegrating tablet preparation comprising fat-soluble active ingredients |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| EP2034953A4 (de) | 2006-06-26 | 2013-05-15 | Capricorn Pharma Inc | Oral zerfallende schichtzusammensetzungen |
| WO2008102264A2 (en) | 2007-02-20 | 2008-08-28 | Eurand Pharmaceuticals Limited | Stable digestive enzyme compositions |
| US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
| DE102009015039A1 (de) * | 2009-03-26 | 2010-09-30 | Bayer Materialscience Ag | Schlagzähmodifizierte Polycarbonat-Zusammensetzungen zur Herstellung metallisierter Formkörper mit homogenem Oberflächenglanz |
| PL2238974T3 (pl) | 2009-04-09 | 2013-09-30 | E Pharma Trento S P A | Granulat do stosowania w preparatach tabletek ulegających rozpadowi w ustach |
| US20110223244A1 (en) * | 2010-03-09 | 2011-09-15 | Elan Pharma International Limited | Alcohol resistant enteric pharmaceutical compositions |
| KR101968457B1 (ko) | 2010-10-01 | 2019-04-11 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 장용 코팅된 저 강도 췌장 리파제 제제 |
| US10195154B2 (en) | 2011-06-10 | 2019-02-05 | Nipro Corporation | Method for producing orodispersible tablets |
| MX351014B (es) | 2011-08-08 | 2017-09-28 | Aptalis Pharma Ltd | Metodo para la prueba de disolucion de composiciones solidas que contienen enzimas digestivas. |
| CN102716171B (zh) * | 2012-06-28 | 2014-05-07 | 江西本草天工科技有限责任公司 | 一种穿心莲复方掩味颗粒及其制备方法 |
| JP6007169B2 (ja) * | 2012-11-30 | 2016-10-12 | 大原薬品工業株式会社 | アリピプラゾール無水物を含有する固形製剤の製造方法 |
| JP2016537387A (ja) | 2013-08-09 | 2016-12-01 | アラガン ファーマシューティカルズ インターナショナル リミテッド | 経腸投与に適した消化酵素組成物 |
| MX2016016907A (es) | 2014-06-19 | 2018-04-26 | Aptalis Pharma Ltd | Metodo para eliminar contaminantes virales de extractos pancreaticos. |
| CN109674757A (zh) * | 2019-02-22 | 2019-04-26 | 济南康和医药科技有限公司 | 一种盐酸特比萘芬组合物及其制备方法 |
| CN116139093A (zh) * | 2022-12-28 | 2023-05-23 | 南京臣功制药股份有限公司 | 一种包含盐酸特比萘芬的速释片剂组合物及其制备工艺 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| FR2754710B1 (fr) * | 1996-10-22 | 1998-12-31 | Prographarm Lab | Procede de preparation d'une forme pharmaceutique multiparticulaire a liberation controlee plurisequentielle |
| FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| US6039979A (en) * | 1999-01-13 | 2000-03-21 | Laboratoires Prographarm | Multiparticulate pharmaceutical form with programmed and pulsed release and process for its preparation |
| NZ513037A (en) * | 1999-01-29 | 2003-05-30 | Disphar Internat B | Coated sustained release pharmaceutical composition for the release of an agent in the gastrointestinal tract |
| FR2790387B1 (fr) * | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
| FR2795962B1 (fr) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
| GB0001315D0 (en) * | 2000-01-20 | 2000-03-08 | Novartis Ag | Organic compounds |
| DE10036871A1 (de) * | 2000-07-28 | 2002-02-14 | Pharmasol Gmbh | Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe |
| FR2816507B1 (fr) * | 2000-11-16 | 2003-02-28 | Ethypharm Lab Prod Ethiques | Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules |
| US20030109583A1 (en) * | 2001-07-25 | 2003-06-12 | Raju Bore G. | Administration of negamycin or deoxynegamycin for the treatment of bacterial infections |
| FR2831820B1 (fr) * | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
| FR2857591B1 (fr) * | 2003-07-17 | 2007-11-02 | Ethypharm Sa | Particules comprenant un principe actif sous forme de co-precipite |
-
2001
- 2001-07-26 DE DE60124895T patent/DE60124895D1/de not_active Expired - Lifetime
- 2001-07-26 AT AT01402027T patent/ATE346590T1/de not_active IP Right Cessation
- 2001-07-26 EP EP01402027A patent/EP1279402B1/de not_active Expired - Lifetime
-
2002
- 2002-07-19 US US10/484,588 patent/US20040220276A1/en not_active Abandoned
- 2002-07-19 JP JP2003515223A patent/JP2005503366A/ja active Pending
- 2002-07-19 WO PCT/EP2002/008103 patent/WO2003009830A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20040220276A1 (en) | 2004-11-04 |
| EP1279402B1 (de) | 2006-11-29 |
| JP2005503366A (ja) | 2005-02-03 |
| EP1279402A1 (de) | 2003-01-29 |
| ATE346590T1 (de) | 2006-12-15 |
| WO2003009830A1 (en) | 2003-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |