[go: up one dir, main page]

FI101857B1 - Menetelmä uuden terapeuttisesti käyttökelpoisen makrosyklisen aminofosfonihappokompleksin valmistamiseksi - Google Patents

Menetelmä uuden terapeuttisesti käyttökelpoisen makrosyklisen aminofosfonihappokompleksin valmistamiseksi

Info

Publication number
FI101857B1
FI101857B1 FI904084A FI904084A FI101857B1 FI 101857 B1 FI101857 B1 FI 101857B1 FI 904084 A FI904084 A FI 904084A FI 904084 A FI904084 A FI 904084A FI 101857 B1 FI101857 B1 FI 101857B1
Authority
FI
Finland
Prior art keywords
preparation
acid complex
therapeutically useful
aminophosphonic acid
novel therapeutically
Prior art date
Application number
FI904084A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101857B (fi
FI904084A0 (fi
Inventor
Jaime Simon
David A Wilson
Joseph R Garlich
David E Troutner
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FI904084A0 publication Critical patent/FI904084A0/fi
Application granted granted Critical
Publication of FI101857B publication Critical patent/FI101857B/fi
Publication of FI101857B1 publication Critical patent/FI101857B1/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FI904084A 1988-12-19 1990-08-17 Menetelmä uuden terapeuttisesti käyttökelpoisen makrosyklisen aminofosfonihappokompleksin valmistamiseksi FI101857B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/284,876 US5059412A (en) 1984-06-04 1988-12-19 Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
PCT/US1989/005782 WO1990006776A1 (en) 1988-12-19 1989-12-15 Macrocyclic aminophosphonic acid complexes, their preparation, formulations and use

Publications (3)

Publication Number Publication Date
FI904084A0 FI904084A0 (fi) 1990-08-17
FI101857B FI101857B (fi) 1998-09-15
FI101857B1 true FI101857B1 (fi) 1998-09-15

Family

ID=23091854

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904084A FI101857B1 (fi) 1988-12-19 1990-08-17 Menetelmä uuden terapeuttisesti käyttökelpoisen makrosyklisen aminofosfonihappokompleksin valmistamiseksi

Country Status (26)

Country Link
US (1) US5059412A (de)
EP (2) EP0408701B1 (de)
JP (1) JP2515929B2 (de)
KR (1) KR0178966B1 (de)
CN (1) CN1025983C (de)
AR (1) AR248140A1 (de)
AT (1) ATE112689T1 (de)
AU (3) AU639899B2 (de)
BR (1) BR8907255A (de)
CA (1) CA2005880C (de)
CY (1) CY1902A (de)
DE (1) DE68918852T2 (de)
DK (1) DK175479B1 (de)
ES (1) ES2061010T3 (de)
FI (1) FI101857B1 (de)
HK (1) HK146795A (de)
HU (1) HU207454B (de)
IE (2) IE940833L (de)
IL (1) IL92784A (de)
MX (1) MX18786A (de)
NO (1) NO180434C (de)
NZ (1) NZ231818A (de)
PT (1) PT92619B (de)
SA (1) SA91120234B1 (de)
WO (1) WO1990006776A1 (de)
ZA (1) ZA899734B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
IL98534A0 (en) * 1990-06-18 1992-07-15 Dow Chemical Co The use of macrocyclic aminophosphonic acid complexes as imaging agents
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
JP3356289B2 (ja) * 1995-06-26 2002-12-16 コンキャット リミティド 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
CA2434302A1 (en) 2001-01-08 2002-08-15 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
WO2002055112A2 (en) * 2001-01-09 2002-07-18 Bristol Myers Squibb Co Polypodal chelants for metallopharmaceuticals
JP2005516933A (ja) * 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
US20030228256A1 (en) * 2002-06-11 2003-12-11 Inverardi Luca A. Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2007008232A2 (en) 2004-09-03 2007-01-18 Board Of Regents, The University Of Texas System Locoregional internal radionuclide ablation of abnormal tissues.
WO2011149844A1 (en) * 2010-05-24 2011-12-01 Iso Therapeutics Group Llc Delivery of high dose therapeutic radioisotopes to bone
SI3054996T1 (sl) 2013-10-07 2023-11-30 Igl Pharma, Inc. Postopek za pripravo terapevtskih sredstev za kosti visoke čistote
US11369700B2 (en) 2015-05-25 2022-06-28 IGL Pharma Inc. DOTMP kit formulations for radioisotopes
JP6930922B2 (ja) * 2015-05-25 2021-09-01 アイジーエル ファーマ，インコーポレイティド 放射性同位体用ｄｏｔｍｐキット製剤
US10793532B2 (en) 2016-09-27 2020-10-06 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
JP7792746B2 (ja) 2017-02-08 2025-12-26 アイジーエル ファーマ，インコーポレイティド 治療用骨剤の使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965254A (en) * 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
US4017595A (en) * 1975-08-28 1977-04-12 Research Corporation Bone-seeking indium-113m or indium-111 organic phosphonate complexes
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
DE3583257D1 (de) * 1984-06-04 1991-07-25 Dow Chemical Co Organische aminphosphonsaeurekomplexe fuer die behandlung von verkalkenden tumoren.
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents

Also Published As

Publication number Publication date
JP2515929B2 (ja) 1996-07-10
NZ231818A (en) 1992-05-26
MX18786A (es) 1993-12-01
US5059412A (en) 1991-10-22
FI101857B (fi) 1998-09-15
EP0408701A4 (en) 1991-07-31
IL92784A (en) 1994-08-26
NO903632L (no) 1990-10-17
CA2005880C (en) 1999-01-05
AU5068593A (en) 1994-02-24
ZA899734B (en) 1991-08-28
AU4700989A (en) 1990-06-21
CN1025983C (zh) 1994-09-28
IE940833L (en) 1990-06-19
SA91120234B1 (ar) 2004-09-04
EP0408701A1 (de) 1991-01-23
PT92619A (pt) 1990-06-29
AU639899B2 (en) 1993-08-12
NO903632D0 (no) 1990-08-17
IL92784A0 (en) 1990-09-17
ES2061010T3 (es) 1994-12-01
EP0408701B1 (de) 1994-10-12
DK175479B1 (da) 2004-11-08
HK146795A (en) 1995-09-22
NO180434B (no) 1997-01-13
DE68918852T2 (de) 1995-05-11
HU207454B (en) 1993-04-28
HU901163D0 (en) 1991-03-28
IE66391B1 (en) 1995-12-27
CN1046739A (zh) 1990-11-07
DK195990D0 (da) 1990-08-16
DK195990A (da) 1990-08-16
CA2005880A1 (en) 1990-06-19
FI904084A0 (fi) 1990-08-17
AU4828290A (en) 1990-07-10
DE68918852D1 (de) 1994-11-17
PT92619B (pt) 1995-09-12
NO180434C (no) 1997-04-23
ATE112689T1 (de) 1994-10-15
JPH03502936A (ja) 1991-07-04
BR8907255A (pt) 1991-03-12
KR910700073A (ko) 1991-03-13
WO1990006776A1 (en) 1990-06-28
CY1902A (en) 1989-12-15
HUT54897A (en) 1991-04-29
AU657641B2 (en) 1995-03-16
IE894063L (en) 1990-06-19
KR0178966B1 (ko) 1999-03-20
EP0375376A3 (de) 1991-06-12
AR248140A1 (es) 1995-06-30
EP0375376A2 (de) 1990-06-27

Similar Documents

Publication Publication Date Title
FI101857B1 (fi) Menetelmä uuden terapeuttisesti käyttökelpoisen makrosyklisen aminofosfonihappokompleksin valmistamiseksi
FI900886A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
FI875660L (fi) Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI875024A7 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
BA98213B1 (bs) Postupak za dobijanje kristalnog azitromicin dihidrata
PT86934A (pt) Process for the preparation of a thiazepine compound
EP0294708A3 (en) Process for the fabrication of a filtermaterial
PT88481A (pt) Process for the preparation of a new cephem compound
FI850654L (fi) Menetelmä terapeuttisesti käyttökelpoisten pleuromutilinijohdannaisten valmistamiseksi
FI853999A7 (fi) Menetelmä terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi.
FI92696C (fi) Menetelmä terapeuttisesti käyttökelpoisten tiatsolidiinidionijohdannaisten valmistamiseksi
FI873350A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI872517A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten makrolidiyhdisteiden valmistamiseksi
FI890283A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 25-hydroksi-vitamiinin D-johdannaisten valmistamiseksi
FI895393A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten alkyylisubstituoitujen 2-alkyyliamiinibentsopyran-6-olien valmistamiseksi
FI90877C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi
FI884910A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten bentsopyraanijohdannaisten valmistamiseksi
FI883997A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-fenyyli-4-kinoliinikarboksyylihappojen valmistamiseksi
PT86631A (pt) Process for the preparation of a novel crystalline form of potassium clavulanate
FI893936A0 (fi) Menetelmä terapeuttisesti aktiivisten yhdisteiden valmistamiseksi sekä välituotteita
FI892948A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI95701C (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI92064C (fi) Menetelmä terapeuttisesti käyttökelpoisten N-bentsopyranyylilaktaamien valmistamiseksi
FI92825C (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
NO173335C (no) Analogifremgangsm}te til fremstilling av en terapeutisk aktiv epipodofyllotoksinaltrosidforbindelse

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: THE DOW CHEMICAL COMPANY