FI107339B - Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi - Google Patents

Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi Download PDF

Info

Publication number: FI107339B
Authority: FI; Finland
Prior art keywords: groups; elastomer; lower alkyl; film; polyalkylene oxide
Prior art date: 1998-06-30

Application number

FI981506A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI981506L (fi

FI981506A0 (fi

Inventor

Jarkko Ruohonen

Matti Lehtinen

Harri Jukarainen

Tommi Markkula

Juha Ala-Sorvari

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-30

Filing date

1998-06-30

Publication date

2001-07-13

1998-06-30 Application filed by Leiras Oy filed Critical Leiras Oy

1998-06-30 Publication of FI981506A0 publication Critical patent/FI981506A0/fi

1998-06-30 Priority to FI981506A priority Critical patent/FI107339B/fi

1999-06-04 Priority to TW088109291A priority patent/TWI237571B/zh

1999-06-08 Priority to CO99035747A priority patent/CO5060523A1/es

1999-06-11 Priority to CZ20004749A priority patent/CZ299613B6/cs

1999-06-11 Priority to DK99931285T priority patent/DK1124902T3/da

1999-06-11 Priority to AU47839/99A priority patent/AU752895B2/en

1999-06-11 Priority to CNB998081388A priority patent/CN1176999C/zh

1999-06-11 Priority to PT99931285T priority patent/PT1124902E/pt

1999-06-11 Priority to PCT/FI1999/000511 priority patent/WO2000000550A1/fr

1999-06-11 Priority to EP99931285A priority patent/EP1124902B1/fr

1999-06-11 Priority to AT99931285T priority patent/ATE290049T1/de

1999-06-11 Priority to JP2000557307A priority patent/JP2002519467A/ja

1999-06-11 Priority to RU2001102606/04A priority patent/RU2201794C2/ru

1999-06-11 Priority to ES99931285T priority patent/ES2237120T3/es

1999-06-11 Priority to CA002336149A priority patent/CA2336149C/fr

1999-06-11 Priority to KR1020007015121A priority patent/KR100599868B1/ko

1999-06-11 Priority to NZ508275A priority patent/NZ508275A/xx

1999-06-11 Priority to SK1894-2000A priority patent/SK285325B6/sk

1999-06-11 Priority to EEP200000788A priority patent/EE04685B1/xx

1999-06-11 Priority to HU0102600A priority patent/HU229159B1/hu

1999-06-11 Priority to CNB031429661A priority patent/CN1269909C/zh

1999-06-11 Priority to BRPI9911140-3A priority patent/BR9911140B1/pt

1999-06-11 Priority to PL99345103A priority patent/PL193485B1/pl

1999-06-11 Priority to HK02100469.0A priority patent/HK1038939B/xx

1999-06-11 Priority to DE69923992T priority patent/DE69923992T2/de

1999-06-25 Priority to ARP990103082A priority patent/AR018952A1/es

1999-06-25 Priority to PE1999000584A priority patent/PE20000935A1/es

1999-11-06 Priority to UA2001010652A priority patent/UA71566C2/uk

1999-12-31 Publication of FI981506L publication Critical patent/FI981506L/fi

2000-11-28 Priority to ZA200006986A priority patent/ZA200006986B/en

2000-12-21 Priority to NO20006581A priority patent/NO327955B1/no

2000-12-21 Priority to BG105081A priority patent/BG65148B1/bg

2001-07-13 Application granted granted Critical

2001-07-13 Publication of FI107339B publication Critical patent/FI107339B/fi

2002-11-18 Priority to US10/298,195 priority patent/US6794464B2/en

2002-11-18 Priority to US10/298,197 priority patent/US6887948B2/en

Links

239000011159 matrix material Substances 0.000 title claims description 25
239000003814 drug Substances 0.000 title description 28
229940079593 drug Drugs 0.000 title description 27
230000035515 penetration Effects 0.000 title description 5
239000000203 mixture Substances 0.000 claims description 112
229920001971 elastomer Polymers 0.000 claims description 69
239000000806 elastomer Substances 0.000 claims description 69
-1 polysiloxane units Polymers 0.000 claims description 69
125000000217 alkyl group Chemical group 0.000 claims description 62
239000003054 catalyst Substances 0.000 claims description 48
229920000233 poly(alkylene oxides) Polymers 0.000 claims description 44
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 40
229920000642 polymer Polymers 0.000 claims description 39
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 37
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 35
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 27
239000001257 hydrogen Substances 0.000 claims description 25
229920001296 polysiloxane Polymers 0.000 claims description 25
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 22
229920002554 vinyl polymer Chemical group 0.000 claims description 22
239000004205 dimethyl polysiloxane Substances 0.000 claims description 21
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 20
238000004132 cross linking Methods 0.000 claims description 19
125000003545 alkoxy group Chemical group 0.000 claims description 14
229920001400 block copolymer Polymers 0.000 claims description 13
229920001002 functional polymer Polymers 0.000 claims description 13
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
239000012528 membrane Substances 0.000 claims description 12
125000002947 alkylene group Chemical group 0.000 claims description 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 9
101150065749 Churc1 gene Proteins 0.000 claims description 9
102100038239 Protein Churchill Human genes 0.000 claims description 9
239000000945 filler Substances 0.000 claims description 9
150000004678 hydrides Chemical class 0.000 claims description 9
150000002431 hydrogen Chemical group 0.000 claims description 8
238000000034 method Methods 0.000 claims description 7
150000002978 peroxides Chemical class 0.000 claims description 6
125000001424 substituent group Chemical group 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
239000000428 dust Substances 0.000 claims description 4
125000003342 alkenyl group Chemical group 0.000 claims description 3
150000001336 alkenes Chemical class 0.000 claims description 2
125000004122 cyclic group Chemical group 0.000 claims description 2
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
240000007594 Oryza sativa Species 0.000 claims 1
235000007164 Oryza sativa Nutrition 0.000 claims 1
125000001931 aliphatic group Chemical group 0.000 claims 1
235000009566 rice Nutrition 0.000 claims 1
239000003112 inhibitor Substances 0.000 description 46
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 41
239000004971 Cross linker Substances 0.000 description 29
238000006243 chemical reaction Methods 0.000 description 25
229910052697 platinum Inorganic materials 0.000 description 21
229920001577 copolymer Polymers 0.000 description 20
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
239000000463 material Substances 0.000 description 15
229920000578 graft copolymer Polymers 0.000 description 14
239000000377 silicon dioxide Substances 0.000 description 13
239000000126 substance Substances 0.000 description 13
238000002156 mixing Methods 0.000 description 12
UBHZUDXTHNMNLD-UHFFFAOYSA-N dimethylsilane Chemical compound C[SiH2]C UBHZUDXTHNMNLD-UHFFFAOYSA-N 0.000 description 8
229920005601 base polymer Polymers 0.000 description 7
229960000834 vinyl ether Drugs 0.000 description 7
239000007858 starting material Substances 0.000 description 6
WRXCBRHBHGNNQA-UHFFFAOYSA-N (2,4-dichlorobenzoyl) 2,4-dichlorobenzenecarboperoxoate Chemical compound ClC1=CC(Cl)=CC=C1C(=O)OOC(=O)C1=CC=C(Cl)C=C1Cl WRXCBRHBHGNNQA-UHFFFAOYSA-N 0.000 description 5
238000006116 polymerization reaction Methods 0.000 description 5
238000012360 testing method Methods 0.000 description 5
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
239000011203 carbon fibre reinforced carbon Substances 0.000 description 4
239000012467 final product Substances 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
230000035699 permeability Effects 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
229920000974 Poly(dimethylsiloxane-ethylene oxide) Polymers 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
230000008878 coupling Effects 0.000 description 3
238000010168 coupling process Methods 0.000 description 3
238000005859 coupling reaction Methods 0.000 description 3
230000009849 deactivation Effects 0.000 description 3
238000000354 decomposition reaction Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
229910052710 silicon Inorganic materials 0.000 description 3
239000002904 solvent Substances 0.000 description 3
150000003431 steroids Chemical class 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
238000007259 addition reaction Methods 0.000 description 2
FSIJKGMIQTVTNP-UHFFFAOYSA-N bis(ethenyl)-methyl-trimethylsilyloxysilane Chemical compound C[Si](C)(C)O[Si](C)(C=C)C=C FSIJKGMIQTVTNP-UHFFFAOYSA-N 0.000 description 2
239000002131 composite material Substances 0.000 description 2
230000008034 disappearance Effects 0.000 description 2
238000004821 distillation Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
125000001033 ether group Chemical group 0.000 description 2
239000000499 gel Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000007943 implant Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
239000010703 silicon Substances 0.000 description 2
229920005573 silicon-containing polymer Polymers 0.000 description 2
239000008096 xylene Substances 0.000 description 2
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
125000006528 (C2-C6) alkyl group Chemical group 0.000 description 1
ZXHDVRATSGZISC-UHFFFAOYSA-N 1,2-bis(ethenoxy)ethane Chemical compound C=COCCOC=C ZXHDVRATSGZISC-UHFFFAOYSA-N 0.000 description 1
LEWNYOKWUAYXPI-UHFFFAOYSA-N 1-ethenylpiperidine Chemical compound C=CN1CCCCC1 LEWNYOKWUAYXPI-UHFFFAOYSA-N 0.000 description 1
QYLFHLNFIHBCPR-UHFFFAOYSA-N 1-ethynylcyclohexan-1-ol Chemical compound C#CC1(O)CCCCC1 QYLFHLNFIHBCPR-UHFFFAOYSA-N 0.000 description 1
WWSJZGAPAVMETJ-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-ethoxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OCC WWSJZGAPAVMETJ-UHFFFAOYSA-N 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
101100494773 Caenorhabditis elegans ctl-2 gene Proteins 0.000 description 1
241000207199 Citrus Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
101100112369 Fasciola hepatica Cat-1 gene Proteins 0.000 description 1
101100005271 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cat-1 gene Proteins 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
241001122767 Theaceae Species 0.000 description 1
AQQGBXNAAFPTIM-UHFFFAOYSA-N [Cd].[Pt] Chemical compound [Cd].[Pt] AQQGBXNAAFPTIM-UHFFFAOYSA-N 0.000 description 1
125000005011 alkyl ether group Chemical group 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
239000003098 androgen Substances 0.000 description 1
229940030486 androgens Drugs 0.000 description 1
230000000708 anti-progestin effect Effects 0.000 description 1
239000003418 antiprogestin Substances 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
239000004305 biphenyl Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
239000005331 crown glasses (windows) Substances 0.000 description 1
150000001923 cyclic compounds Chemical class 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
150000002159 estradiols Chemical class 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
230000030279 gene silencing Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000000976 ink Substances 0.000 description 1
229960004400 levonorgestrel Drugs 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
210000003899 penis Anatomy 0.000 description 1
239000012466 permeate Substances 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002959 polymer blend Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000000583 progesterone congener Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000007790 scraping Methods 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229940126703 systemic medication Drugs 0.000 description 1
239000003760 tallow Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
- C08L83/12—Block- or graft-copolymers containing polysiloxane sequences containing polyether sequences
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Polymers & Plastics (AREA)
Silicon Polymers (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Wrappers (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Materials For Medical Uses (AREA)
Processes Of Treating Macromolecular Substances (AREA)

FI981506A 1998-06-30 1998-06-30 Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi FI107339B (fi)

Priority Applications (33)

Application Number	Priority Date	Filing Date	Title
FI981506A FI107339B (fi)	1998-06-30	1998-06-30	Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi
TW088109291A TWI237571B (en)	1998-06-30	1999-06-04	A membrane or matrix for controlling the permeation rate of drugs
CO99035747A CO5060523A1 (es)	1998-06-30	1999-06-08	Una membrana o matriz para controlar la velocidad de penetracion de farmacos
NZ508275A NZ508275A (en)	1998-06-30	1999-06-11	A membrane or matrix containing siloxane based elastomer for controlling the permeation rate of drugs
CNB031429661A CN1269909C (zh)	1998-06-30	1999-06-11	制备基于硅氧烷的弹性体的方法
AU47839/99A AU752895B2 (en)	1998-06-30	1999-06-11	A membrane or matrix for controlling the permeation rate of drugs
CNB998081388A CN1176999C (zh)	1998-06-30	1999-06-11	一种控制药物渗透速率的膜或基体
PT99931285T PT1124902E (pt)	1998-06-30	1999-06-11	Membrana ou matriz para controlo da velocidade de permeacao de farmacos
PCT/FI1999/000511 WO2000000550A1 (fr)	1998-06-30	1999-06-11	Membrane ou matrice permettant de reguler la vitesse de permeation des medicaments
EP99931285A EP1124902B1 (fr)	1998-06-30	1999-06-11	Membrane ou matrice permettant de reguler la vitesse de permeation des medicaments
AT99931285T ATE290049T1 (de)	1998-06-30	1999-06-11	Membran oder matrix zur steuerung der freisetzungsgeschwindigkeit von arzneistoffen
JP2000557307A JP2002519467A (ja)	1998-06-30	1999-06-11	薬物の透過速度を調節する膜又はマトリックス
RU2001102606/04A RU2201794C2 (ru)	1998-06-30	1999-06-11	Мембрана или матрица для регулирования скорости проникновения лекарственных средств
ES99931285T ES2237120T3 (es)	1998-06-30	1999-06-11	Membrana o matriz para el control de la velocidad de permeacion de farmacos.
CA002336149A CA2336149C (fr)	1998-06-30	1999-06-11	Membrane ou matrice permettant de reguler la vitesse de permeation des medicaments
KR1020007015121A KR100599868B1 (ko)	1998-06-30	1999-06-11	약물의 투과속도 조절을 위한 막 또는 매트릭스
CZ20004749A CZ299613B6 (cs)	1998-06-30	1999-06-11	Membrána nebo matrice pro rízení rychlosti permeace léku obsahující kompozici na bázi elastomeru siloxanu a zpusob prípravy elastomeru
SK1894-2000A SK285325B6 (sk)	1998-06-30	1999-06-11	Membrána alebo matrica na riadenie rýchlosti permeácie liekov, ktorá obsahuje elastomérnu kompozíciu na báze siloxánu, obsahujúca aspoň jeden elastomér a prípadne nezosieťovaný polymér a spôsob prípravy elastoméru
EEP200000788A EE04685B1 (et)	1998-06-30	1999-06-11	Ravimi lbimiskiirust kontrolliv membraan v?i maatriks
HU0102600A HU229159B1 (hu)	1998-06-30	1999-06-11	Gyógyszerek permeációs sebességét szabályozó membrán vagy mátrix
DK99931285T DK1124902T3 (da)	1998-06-30	1999-06-11	Membran eller matrix til kontrol af permeationsgraden for medikamenter
BRPI9911140-3A BR9911140B1 (pt)	1998-06-30	1999-06-11	membrana ou matriz para controlar a velocidade de permeação de fármacos e método para preparação de um elastÈmero.
PL99345103A PL193485B1 (pl)	1998-06-30	1999-06-11	Błona lub matryca do kontrolowania prędkości przenikania leku
HK02100469.0A HK1038939B (en)	1998-06-30	1999-06-11	A membrane or matrix for controlling the permeation rate of drugs
DE69923992T DE69923992T2 (de)	1998-06-30	1999-06-11	Membran oder Matrix zur Steuerung der Permeationsrate eines Wirkstoffs
ARP990103082A AR018952A1 (es)	1998-06-30	1999-06-25	Una membrana o matriz para controlar la velocidad de penetracion de farmacos
PE1999000584A PE20000935A1 (es)	1998-06-30	1999-06-25	Una membrana o matriz para controlar la velocidad de penetracion de farmacos
UA2001010652A UA71566C2 (uk)	1998-06-30	1999-11-06	Мембрана для регулювання швидкості проникнення лікарських засобів
ZA200006986A ZA200006986B (en)	1998-06-30	2000-11-28	A membrane or matrix for controlling the permeation rate of drugs.
NO20006581A NO327955B1 (no)	1998-06-30	2000-12-21	Membran eller matriks for a regulere permeeringshastigheten for medikamenter
BG105081A BG65148B1 (bg)	1998-06-30	2000-12-21	Мембрана или матрица за контрол на степента на проникване на лекарствени средства
US10/298,195 US6794464B2 (en)	1998-06-30	2002-11-18	Membrane or matrix for controlling the permeation rate of drugs
US10/298,197 US6887948B2 (en)	1998-06-30	2002-11-18	Method for preparing a siloxane-based elastomer composition

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI981506		1998-06-30
FI981506A FI107339B (fi)	1998-06-30	1998-06-30	Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi

Publications (3)

Publication Number	Publication Date
FI981506A0 FI981506A0 (fi)	1998-06-30
FI981506L FI981506L (fi)	1999-12-31
FI107339B true FI107339B (fi)	2001-07-13

Family

ID=8552104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI981506A FI107339B (fi)	1998-06-30	1998-06-30	Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi

Country Status (28)

Country	Link
EP (1)	EP1124902B1 (fr)
JP (1)	JP2002519467A (fr)
KR (1)	KR100599868B1 (fr)
CN (2)	CN1269909C (fr)
AR (1)	AR018952A1 (fr)
AT (1)	ATE290049T1 (fr)
AU (1)	AU752895B2 (fr)
BG (1)	BG65148B1 (fr)
BR (1)	BR9911140B1 (fr)
CA (1)	CA2336149C (fr)
CO (1)	CO5060523A1 (fr)
CZ (1)	CZ299613B6 (fr)
DE (1)	DE69923992T2 (fr)
EE (1)	EE04685B1 (fr)
ES (1)	ES2237120T3 (fr)
FI (1)	FI107339B (fr)
HU (1)	HU229159B1 (fr)
NO (1)	NO327955B1 (fr)
NZ (1)	NZ508275A (fr)
PE (1)	PE20000935A1 (fr)
PL (1)	PL193485B1 (fr)
PT (1)	PT1124902E (fr)
RU (1)	RU2201794C2 (fr)
SK (1)	SK285325B6 (fr)
TW (1)	TWI237571B (fr)
UA (1)	UA71566C2 (fr)
WO (1)	WO2000000550A1 (fr)
ZA (1)	ZA200006986B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008110666A1 (fr)	2007-03-12	2008-09-18	Bayer Schering Pharma Oy	Utilisation du tocophérol

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US6476079B1 (en)	1999-12-23	2002-11-05	Leiras Oy	Devices for the delivery of drugs having antiprogestinic properties
WO2002032433A1 (fr) *	2000-10-20	2002-04-25	Leiras Oy	Systeme d'administration de medicament
EP1438942A1 (fr)	2003-01-17	2004-07-21	Schering Oy	Dispositif d'administration de médicament otologique et rhinologique
ES2300048T3 (es) *	2004-08-25	2008-06-01	UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION	Pelicula polimerica.
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
EP2140860A1 (fr)	2008-07-03	2010-01-06	Bayer Schering Pharma Oy	Procédé de contraception amélioré
PT2349143E (pt)	2008-09-17	2013-07-08	Bayer Oy	Um dispositivo de inserção
FI20080524A0 (fi)	2008-09-17	2008-09-17	Bayer Schering Pharma Oy	Insertteri
FI20080523A0 (fi)	2008-09-17	2008-09-17	Bayer Schering Pharma Oy	Insertteri
US11992431B2 (en)	2008-09-17	2024-05-28	Bayer Oy	Inserter
FI122579B (fi)	2010-10-29	2012-03-30	Bayer Oy	Insertteri
CN102068914B (zh) *	2010-12-13	2012-10-10	大连欧科膜技术工程有限公司	一种气体分离复合膜的制备方法
CN102008909B (zh) *	2010-12-13	2012-10-10	大连欧科膜技术工程有限公司	一种气体分离复合膜的制备方法
BR112014026086A2 (pt)	2012-04-23	2017-07-18	Bayer Pharma AG	aplicação de 18-metil-15beta,16beta-metilen-19-nor-20-spirox-4-en-3-onas na terapia da menorragia, bem como sistemas intrauterinos contendo 18-metil-15beta,16beta-metilen-19-nor-20-spirox-4-en-3-onas para a terapia de distúrbios de sangramento uterino
TW201350122A (zh)	2012-04-23	2013-12-16	Bayer Pharma AG	１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
WO2015055635A1 (fr) *	2013-10-18	2015-04-23	Bayer Oy	Dispositif d'administration par voie intra-utérine
US11096888B2 (en)	2015-05-13	2021-08-24	Bayer Oy	Long acting drug delivery device and its use in contraception
WO2018202574A1 (fr)	2017-05-04	2018-11-08	Bayer Oy	Système d'administration de médicament intravaginal, procédé de fabrication d'un tel système et son utilisation dans des thérapies gynécologiques et en contraception
WO2019119059A1 (fr)	2017-12-22	2019-06-27	Alyra Biotech Pty Ltd	Traitement de la douleur et/ou des symptômes liés à la douleur associés à la dysménorrhée
EP3536735B1 (fr) *	2018-03-05	2020-10-14	Evonik Operations GmbH	Copolymères bloc de polyéther-siloxane réticulés ainsi que leur utilisation pour la fabrication de mousses en polyuréthane
EP3976013A4 (fr)	2019-05-31	2023-05-31	Alyra Biotech Pty Ltd	Procédés, compositions et dispositifs pour traiter des états neuroinflammatoires

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US5889108A (en) *	1997-06-02	1999-03-30	Dow Corning Corporation	Thickening solvents with elastomeric silicone polyethers

1998
- 1998-06-30 FI FI981506A patent/FI107339B/fi not_active IP Right Cessation
1999
- 1999-06-04 TW TW088109291A patent/TWI237571B/zh not_active IP Right Cessation
- 1999-06-08 CO CO99035747A patent/CO5060523A1/es unknown
- 1999-06-11 KR KR1020007015121A patent/KR100599868B1/ko not_active Expired - Fee Related
- 1999-06-11 EP EP99931285A patent/EP1124902B1/fr not_active Expired - Lifetime
- 1999-06-11 CN CNB031429661A patent/CN1269909C/zh not_active Expired - Fee Related
- 1999-06-11 EE EEP200000788A patent/EE04685B1/xx not_active IP Right Cessation
- 1999-06-11 NZ NZ508275A patent/NZ508275A/xx not_active IP Right Cessation
- 1999-06-11 SK SK1894-2000A patent/SK285325B6/sk not_active IP Right Cessation
- 1999-06-11 WO PCT/FI1999/000511 patent/WO2000000550A1/fr not_active Ceased
- 1999-06-11 AT AT99931285T patent/ATE290049T1/de active
- 1999-06-11 DE DE69923992T patent/DE69923992T2/de not_active Expired - Lifetime
- 1999-06-11 HU HU0102600A patent/HU229159B1/hu not_active IP Right Cessation
- 1999-06-11 RU RU2001102606/04A patent/RU2201794C2/ru not_active IP Right Cessation
- 1999-06-11 ES ES99931285T patent/ES2237120T3/es not_active Expired - Lifetime
- 1999-06-11 JP JP2000557307A patent/JP2002519467A/ja active Pending
- 1999-06-11 CN CNB998081388A patent/CN1176999C/zh not_active Expired - Fee Related
- 1999-06-11 CA CA002336149A patent/CA2336149C/fr not_active Expired - Fee Related
- 1999-06-11 PL PL99345103A patent/PL193485B1/pl unknown
- 1999-06-11 PT PT99931285T patent/PT1124902E/pt unknown
- 1999-06-11 BR BRPI9911140-3A patent/BR9911140B1/pt not_active IP Right Cessation
- 1999-06-11 AU AU47839/99A patent/AU752895B2/en not_active Ceased
- 1999-06-11 CZ CZ20004749A patent/CZ299613B6/cs not_active IP Right Cessation
- 1999-06-25 AR ARP990103082A patent/AR018952A1/es active IP Right Grant
- 1999-06-25 PE PE1999000584A patent/PE20000935A1/es not_active Application Discontinuation
- 1999-11-06 UA UA2001010652A patent/UA71566C2/uk unknown
2000
- 2000-11-28 ZA ZA200006986A patent/ZA200006986B/en unknown
- 2000-12-21 BG BG105081A patent/BG65148B1/bg unknown
- 2000-12-21 NO NO20006581A patent/NO327955B1/no not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008110666A1 (fr)	2007-03-12	2008-09-18	Bayer Schering Pharma Oy	Utilisation du tocophérol

Also Published As

Publication number	Publication date
EP1124902B1 (fr)	2005-03-02
AR018952A1 (es)	2001-12-12
BG65148B1 (bg)	2007-04-30
CO5060523A1 (es)	2001-07-30
CN1269909C (zh)	2006-08-16
CN1308653A (zh)	2001-08-15
WO2000000550A1 (fr)	2000-01-06
HUP0102600A3 (en)	2004-04-28
FI981506L (fi)	1999-12-31
SK18942000A3 (sk)	2001-07-10
ATE290049T1 (de)	2005-03-15
NO20006581L (no)	2000-12-29
NO327955B1 (no)	2009-10-26
BG105081A (en)	2001-09-28
AU4783999A (en)	2000-01-17
EP1124902A1 (fr)	2001-08-22
FI981506A0 (fi)	1998-06-30
KR100599868B1 (ko)	2006-07-12
SK285325B6 (sk)	2006-11-03
DE69923992T2 (de)	2006-04-13
CZ299613B6 (cs)	2008-09-17
ZA200006986B (en)	2001-05-23
RU2201794C2 (ru)	2003-04-10
PT1124902E (pt)	2005-07-29
DE69923992D1 (de)	2005-04-07
PE20000935A1 (es)	2000-09-18
TWI237571B (en)	2005-08-11
EE04685B1 (et)	2006-08-15
BR9911140B1 (pt)	2009-08-11
KR20010053346A (ko)	2001-06-25
HU229159B1 (hu)	2013-09-30
ES2237120T3 (es)	2005-07-16
CA2336149C (fr)	2007-01-02
NO20006581D0 (no)	2000-12-21
PL193485B1 (pl)	2007-02-28
PL345103A1 (en)	2001-12-03
CN1176999C (zh)	2004-11-24
CZ20004749A3 (cs)	2001-10-17
CA2336149A1 (fr)	2000-01-06
CN1488678A (zh)	2004-04-14
UA71566C2 (uk)	2004-12-15
HUP0102600A2 (hu)	2001-11-28
NZ508275A (en)	2002-09-27
JP2002519467A (ja)	2002-07-02
HK1038939A1 (en)	2002-04-04
AU752895B2 (en)	2002-10-03
BR9911140A (pt)	2001-03-06
EE200000788A (et)	2002-04-15

Publication	Publication Date	Title
FI107339B (fi)	2001-07-13	Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi
EP0398745B1 (fr)	1996-09-04	Compositions de silicone durcissables
CA2027866C (fr)	2001-04-24	Mousses de silicone
US5145933A (en)	1992-09-08	Organosiloxane gel-forming compositions and use thereof
JP2818781B2 (ja)	1998-10-30	オルガノシロキサンゲル形成用組成物及びその使用方法
JP2015507671A (ja)	2015-03-12	親水性シリコーンゲル接着剤
JPH0672084B2 (ja)	1994-09-14	印象材組成物
EP1290998A1 (fr)	2003-03-12	Matériau pour empreinte dentaire
EP1970874B1 (fr)	2012-06-20	Inhibiteur d'hydrosilylation, composition de catalyseur d'hydrosilylation et composition durcissable
IL199765A (en)	2013-08-29	A method for producing hydrophilic polysiloxanes by using tocopherol as a catalyst
US5494750A (en)	1996-02-27	Heat-curable silicone elastomer composition
US6794464B2 (en)	2004-09-21	Membrane or matrix for controlling the permeation rate of drugs
CA2036095C (fr)	1999-01-12	Melange homogene dont les proprietes sont ameliorees au cours d'un traitement
US20030096921A1 (en)	2003-05-22	Method for preparing a siloxane-based elastomer composition
CA2085319A1 (fr)	1993-06-22	Composition formant une mousse de silicone
KR102756905B1 (ko)	2025-01-22	활성 성분 용출을 개선시키기 위한 약물 전달 실리콘 조성물
MXPA00012749A (en)	2001-07-31	A membrane or matrix for controlling the permeation rate of drugs
JPH0257821B2 (fr)	1990-12-06
JPH02305858A (ja)	1990-12-19	硬化性シリコーン組成物

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Date	Code	Title	Description
2008-05-08	PC	Transfer of assignment of patent	Owner name: BAYER SCHERING PHARMA OY Free format text: BAYER SCHERING PHARMA OY
2016-01-20	MM	Patent lapsed

Date

Code

Title

Description

2008-05-08

Transfer of assignment of patent

Owner name: BAYER SCHERING PHARMA OY

Free format text: BAYER SCHERING PHARMA OY

2016-01-20

Patent lapsed

FI107339B - Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi - Google Patents

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Priority Applications (33)

Applications Claiming Priority (2)

Publications (3)

Family

ID=8552104

Family Applications (1)

Country Status (28)

Cited By (1)

Families Citing this family (21)

Family Cites Families (1)

Cited By (1)

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