FI105074B - Farmaseuttisen formulaation valmistusmenetelmä - Google Patents
Farmaseuttisen formulaation valmistusmenetelmä Download PDFInfo
- Publication number
- FI105074B FI105074B FI974664A FI974664A FI105074B FI 105074 B FI105074 B FI 105074B FI 974664 A FI974664 A FI 974664A FI 974664 A FI974664 A FI 974664A FI 105074 B FI105074 B FI 105074B
- Authority
- FI
- Finland
- Prior art keywords
- suspension
- process according
- particles
- drug
- active ingredient
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 28
- 238000002360 preparation method Methods 0.000 title description 6
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims description 27
- 239000000725 suspension Substances 0.000 claims description 25
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 24
- 238000009472 formulation Methods 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229960002052 salbutamol Drugs 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 4
- 238000000527 sonication Methods 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 150000008282 halocarbons Chemical class 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical group 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 125000002345 steroid group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 description 33
- 229940079593 drug Drugs 0.000 description 33
- 238000002441 X-ray diffraction Methods 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 229960001375 lactose Drugs 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 3
- 239000008240 homogeneous mixture Substances 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000007580 dry-mixing Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- ODNRPNYOGYFTAB-GTDRIFFSSA-N O.OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](O)C(O)O[C@@H]1CO Chemical compound O.OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](O)C(O)O[C@@H]1CO ODNRPNYOGYFTAB-GTDRIFFSSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000012296 anti-solvent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 238000010336 energy treatment Methods 0.000 description 1
- UMYZHWLYICNGRQ-UHFFFAOYSA-N ethanol;heptane Chemical compound CCO.CCCCCCC UMYZHWLYICNGRQ-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- DZVVLBSDPBGJEM-UHFFFAOYSA-N heptane;hydrate Chemical compound O.CCCCCCC DZVVLBSDPBGJEM-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI974664A FI105074B (fi) | 1997-12-31 | 1997-12-31 | Farmaseuttisen formulaation valmistusmenetelmä |
| CNB988126222A CN1172659C (zh) | 1997-12-31 | 1998-12-21 | 一种药物制剂的制备方法 |
| EEP2000004010A EE04993B1 (et) | 1997-12-31 | 1998-12-21 | Inhalatsioonipulbri valmistamismeetod |
| DE1041971T DE1041971T1 (de) | 1997-12-31 | 1998-12-21 | Eine methode zur herstellung einer pharmazeutischen zusammensetzung |
| NZ505400A NZ505400A (en) | 1997-12-31 | 1998-12-21 | A method for making a homogeneous powdered pharmaceutical formulation by suspending particles in suspending agent, then evaporating suspending agent |
| PCT/FI1998/001001 WO1999034778A1 (en) | 1997-12-31 | 1998-12-21 | A method for making a pharmaceutical formulation |
| US09/582,370 US6616945B1 (en) | 1997-12-31 | 1998-12-21 | Method for making a pharmaceutical formulation |
| PL98341410A PL341410A1 (en) | 1997-12-31 | 1998-12-21 | Method of obtaining a pharmacological composition |
| KR1020007007248A KR20010033725A (ko) | 1997-12-31 | 1998-12-21 | 약제학적 제형의 제조방법 |
| IL13701798A IL137017A0 (en) | 1997-12-31 | 1998-12-21 | A method for making a pharmaceutical formulation |
| EP98962441A EP1041971A1 (en) | 1997-12-31 | 1998-12-21 | A method for making a pharmaceutical formulation |
| RU2000120196/14A RU2203045C2 (ru) | 1997-12-31 | 1998-12-21 | Способ получения фармацевтического состава |
| JP2000527229A JP4131610B2 (ja) | 1997-12-31 | 1998-12-21 | 医薬製剤の製造方法 |
| AU17608/99A AU754074B2 (en) | 1997-12-31 | 1998-12-21 | A method for making a pharmaceutical formulation |
| HU0100398A HUP0100398A2 (hu) | 1997-12-31 | 1998-12-21 | Eljárás gyógyászati készítmény előállítására |
| CA002314112A CA2314112C (en) | 1997-12-31 | 1998-12-21 | A method for making a pharmaceutical formulation |
| NO20003393A NO20003393L (no) | 1997-12-31 | 2000-06-29 | FremgangsmÕte for fremstilling av en farmasøytisk formulering |
| JP2007264197A JP2008019279A (ja) | 1997-12-31 | 2007-10-10 | 医薬製剤の製造方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI974664A FI105074B (fi) | 1997-12-31 | 1997-12-31 | Farmaseuttisen formulaation valmistusmenetelmä |
| FI974664 | 1997-12-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI974664A0 FI974664A0 (fi) | 1997-12-31 |
| FI974664L FI974664L (fi) | 1999-07-01 |
| FI105074B true FI105074B (fi) | 2000-06-15 |
Family
ID=8550254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI974664A FI105074B (fi) | 1997-12-31 | 1997-12-31 | Farmaseuttisen formulaation valmistusmenetelmä |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6616945B1 (et) |
| EP (1) | EP1041971A1 (et) |
| JP (2) | JP4131610B2 (et) |
| KR (1) | KR20010033725A (et) |
| CN (1) | CN1172659C (et) |
| AU (1) | AU754074B2 (et) |
| CA (1) | CA2314112C (et) |
| DE (1) | DE1041971T1 (et) |
| EE (1) | EE04993B1 (et) |
| FI (1) | FI105074B (et) |
| HU (1) | HUP0100398A2 (et) |
| IL (1) | IL137017A0 (et) |
| NO (1) | NO20003393L (et) |
| NZ (1) | NZ505400A (et) |
| PL (1) | PL341410A1 (et) |
| RU (1) | RU2203045C2 (et) |
| WO (1) | WO1999034778A1 (et) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI116657B (fi) * | 2002-03-28 | 2006-01-31 | Focus Inhalation Oy | Menetelmä kantoainehiukkasten käsittelemiseksi ja niiden käyttö |
| PL207752B1 (pl) * | 2002-04-04 | 2011-01-31 | Boehringer Ingelheim Pharma | Sposób otrzymywania trwałego fizycznie i jednorodnego sproszkowanego preparatu zawierającego tiotropium, sproszkowany preparat i jego zastosowanie |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| WO2009046215A2 (en) * | 2007-10-02 | 2009-04-09 | Lab International Srl | Safety and abuse deterrent improved device |
| WO2012053654A1 (en) | 2010-10-18 | 2012-04-26 | Dainippon Sumitomo Pharma Co., Ltd. | Sustained-release formulation for injection |
| CN110025578B (zh) * | 2019-04-10 | 2021-06-15 | 深圳市新阳唯康科技有限公司 | 一种治疗哮喘类肺部疾病的共无定形粉末及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB937303A (en) * | 1959-01-02 | 1963-09-18 | Benger Lab Ltd | Improvements in and relating to the application of drugs in finely divided condition |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| WO1990013327A1 (en) | 1989-04-28 | 1990-11-15 | Riker Laboratories, Inc. | Dry powder inhalation device |
| SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| SE9101090D0 (sv) * | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| US5191114A (en) * | 1991-10-09 | 1993-03-02 | Sage Pharmaceuticals, Inc. | Process for enhancing the flow characteristics of ibuprofen |
| US5393716A (en) * | 1992-09-25 | 1995-02-28 | Ecc International Limited | Process for producing anti-blocking compositions |
| US5503869A (en) * | 1994-10-21 | 1996-04-02 | Glaxo Wellcome Inc. | Process for forming medicament carrier for dry powder inhalator |
| RU2071317C1 (ru) * | 1994-12-21 | 1997-01-10 | Александр Григорьевич Чучалин | Лекарственный порошкообразный препарат для ингаляций |
| GB9610821D0 (en) * | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
-
1997
- 1997-12-31 FI FI974664A patent/FI105074B/fi active
-
1998
- 1998-12-21 NZ NZ505400A patent/NZ505400A/xx unknown
- 1998-12-21 PL PL98341410A patent/PL341410A1/xx unknown
- 1998-12-21 RU RU2000120196/14A patent/RU2203045C2/ru not_active IP Right Cessation
- 1998-12-21 DE DE1041971T patent/DE1041971T1/de active Pending
- 1998-12-21 JP JP2000527229A patent/JP4131610B2/ja not_active Expired - Fee Related
- 1998-12-21 AU AU17608/99A patent/AU754074B2/en not_active Ceased
- 1998-12-21 KR KR1020007007248A patent/KR20010033725A/ko not_active Ceased
- 1998-12-21 HU HU0100398A patent/HUP0100398A2/hu unknown
- 1998-12-21 EE EEP2000004010A patent/EE04993B1/et not_active IP Right Cessation
- 1998-12-21 EP EP98962441A patent/EP1041971A1/en not_active Ceased
- 1998-12-21 WO PCT/FI1998/001001 patent/WO1999034778A1/en not_active Ceased
- 1998-12-21 CN CNB988126222A patent/CN1172659C/zh not_active Expired - Fee Related
- 1998-12-21 US US09/582,370 patent/US6616945B1/en not_active Expired - Fee Related
- 1998-12-21 IL IL13701798A patent/IL137017A0/xx not_active IP Right Cessation
- 1998-12-21 CA CA002314112A patent/CA2314112C/en not_active Expired - Fee Related
-
2000
- 2000-06-29 NO NO20003393A patent/NO20003393L/no not_active Application Discontinuation
-
2007
- 2007-10-10 JP JP2007264197A patent/JP2008019279A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1172659C (zh) | 2004-10-27 |
| IL137017A0 (en) | 2001-06-14 |
| JP2008019279A (ja) | 2008-01-31 |
| NO20003393D0 (no) | 2000-06-29 |
| JP2002500176A (ja) | 2002-01-08 |
| EP1041971A1 (en) | 2000-10-11 |
| PL341410A1 (en) | 2001-04-09 |
| EE200000401A (et) | 2001-10-15 |
| RU2203045C2 (ru) | 2003-04-27 |
| FI974664L (fi) | 1999-07-01 |
| AU754074B2 (en) | 2002-11-07 |
| WO1999034778A1 (en) | 1999-07-15 |
| AU1760899A (en) | 1999-07-26 |
| DE1041971T1 (de) | 2001-02-08 |
| FI974664A0 (fi) | 1997-12-31 |
| NO20003393L (no) | 2000-07-31 |
| KR20010033725A (ko) | 2001-04-25 |
| US6616945B1 (en) | 2003-09-09 |
| CA2314112C (en) | 2008-06-17 |
| NZ505400A (en) | 2003-06-30 |
| EE04993B1 (et) | 2008-04-15 |
| CN1283109A (zh) | 2001-02-07 |
| JP4131610B2 (ja) | 2008-08-13 |
| CA2314112A1 (en) | 1999-07-15 |
| HUP0100398A2 (hu) | 2001-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: LAB PHARMA OY Free format text: LAB PHARMA OY |