GB937303A - Improvements in and relating to the application of drugs in finely divided condition - Google Patents
Improvements in and relating to the application of drugs in finely divided conditionInfo
- Publication number
- GB937303A GB937303A GB28559A GB28559A GB937303A GB 937303 A GB937303 A GB 937303A GB 28559 A GB28559 A GB 28559A GB 28559 A GB28559 A GB 28559A GB 937303 A GB937303 A GB 937303A
- Authority
- GB
- United Kingdom
- Prior art keywords
- drug
- solvent
- mean diameter
- solvents
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 10
- 229940079593 drug Drugs 0.000 title abstract 10
- 239000002904 solvent Substances 0.000 abstract 7
- 239000007788 liquid Substances 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- ZOLBALGTFCCTJF-UHFFFAOYSA-N 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;sulfuric acid Chemical compound OS(O)(=O)=O.CC(C)NCC(O)C1=CC=C(O)C(O)=C1.CC(C)NCC(O)C1=CC=C(O)C(O)=C1 ZOLBALGTFCCTJF-UHFFFAOYSA-N 0.000 abstract 1
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 238000010908 decantation Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000009775 high-speed stirring Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a drug in the form of a homogeneous ultra-fine powder for administration by inhalation at least two-thirds, preferably 80%, of whose weight consists of particles within the range 2-6m , preferably 3m , mean diameter and which contains substantially no particles larger than 10m , preferably 7m , mean diameter and a negligible proportion by weight of particles smaller than 1m mean diameter. Specified drugs are chymotrypsin or isoprenaline sulphate. The drug in homogeneous ultra-fine powder form is prepared by forming a suspension of the drug in finely divided form by precipitating the drug from a solution thereof in a solvent therefor by addition of a solvent miscible with said solvent but in which the drug is insoluble, freezing the suspension, if desired after washing and/or concentration, to a microcrystalline form and subsequently removing the frozen liquid, by distillation, under reduced pressure. Homogeneity is improved by high-speed stirring during mixing of the two liquids, subjecting the mixed liquids to ultrasonic vibrations or seeding with nuclei from a previous run. The powdered drug may also be prepared by forming a medicinally inert carrier, e.g. a low molecular weight dextran fraction as above and absorbing the drug therein from solution and freeze drying as above. Specified solvents employed are water, water-miscible solvents, e.g. methanol, ethanol, isopropanol, tertiary butanol or acetone or waterimmiscible solvents, e.g. ether or benzene. The wet preparation obtained by precipitation or absorbtion on a preformed carrier precipitate may prior to freezing be washed, concentrated by filtration or decantation with another solvent having different physical characteristics to that in which the powder is suspended, i.e. any liquid in which the drug and inert carrier, if present, are insoluble. Specification 898,649 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28559A GB937303A (en) | 1959-01-02 | 1959-01-02 | Improvements in and relating to the application of drugs in finely divided condition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28559A GB937303A (en) | 1959-01-02 | 1959-01-02 | Improvements in and relating to the application of drugs in finely divided condition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB937303A true GB937303A (en) | 1963-09-18 |
Family
ID=9701676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28559A Expired GB937303A (en) | 1959-01-02 | 1959-01-02 | Improvements in and relating to the application of drugs in finely divided condition |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB937303A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2423218A1 (en) * | 1977-11-30 | 1979-11-16 | Fisons Ltd | PHARMACEUTICAL COMPOSITION BASED ON BECLOMETHASONE DIPROPIONATE |
| EP0465841A3 (en) * | 1990-06-13 | 1992-10-14 | Hoechst Aktiengesellschaft | Quick acting pharmaceutical inhalation forms of diuretics |
| WO1999034778A1 (en) * | 1997-12-31 | 1999-07-15 | Leiras Oy | A method for making a pharmaceutical formulation |
| WO1999052506A1 (en) * | 1998-04-09 | 1999-10-21 | Axiva Gmbh | Particulate active agent support for pulmonary application |
| RU2372092C1 (en) * | 2008-04-25 | 2009-11-10 | Кирилл Сергеевич Голохваст | Method of preparing inhalation powder |
-
1959
- 1959-01-02 GB GB28559A patent/GB937303A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2423218A1 (en) * | 1977-11-30 | 1979-11-16 | Fisons Ltd | PHARMACEUTICAL COMPOSITION BASED ON BECLOMETHASONE DIPROPIONATE |
| EP0465841A3 (en) * | 1990-06-13 | 1992-10-14 | Hoechst Aktiengesellschaft | Quick acting pharmaceutical inhalation forms of diuretics |
| WO1999034778A1 (en) * | 1997-12-31 | 1999-07-15 | Leiras Oy | A method for making a pharmaceutical formulation |
| US6616945B1 (en) | 1997-12-31 | 2003-09-09 | Leiras Oy | Method for making a pharmaceutical formulation |
| WO1999052506A1 (en) * | 1998-04-09 | 1999-10-21 | Axiva Gmbh | Particulate active agent support for pulmonary application |
| RU2372092C1 (en) * | 2008-04-25 | 2009-11-10 | Кирилл Сергеевич Голохваст | Method of preparing inhalation powder |
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