FI104178B1 - 17-spirofuran-3'-ylideenisteroidit - Google Patents

17-spirofuran-3'-ylideenisteroidit

Info

Publication number: FI104178B1
Authority: FI; Finland
Prior art keywords: lower alkyl; hydrogen; spirofuran; ylidensteroider; acyl
Prior art date: 1991-12-20

Application number

FI925790A

Other languages

English (en)

Swedish (sv)

Other versions

FI925790L (fi

FI104178B (fi

FI925790A0 (fi

Inventor

Johannes Antonius Mar Hamersma

Everardus Otto Maria Orlemans

Johannes Bernardus Ma Rewinkel

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-18

Publication date

1999-11-30

1992-12-18 Application filed by Akzo Nv filed Critical Akzo Nv

1992-12-18 Publication of FI925790A0 publication Critical patent/FI925790A0/fi

1993-06-21 Publication of FI925790L publication Critical patent/FI925790L/fi

1999-11-30 Application granted granted Critical

1999-11-30 Publication of FI104178B publication Critical patent/FI104178B/fi

1999-11-30 Publication of FI104178B1 publication Critical patent/FI104178B1/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)

FI925790A 1991-12-20 1992-12-18 17-spirofuran-3'-ylideenisteroidit FI104178B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP91203366		1991-12-20
EP91203366		1991-12-20

Publications (4)

Publication Number	Publication Date
FI925790A0 FI925790A0 (fi)	1992-12-18
FI925790L FI925790L (fi)	1993-06-21
FI104178B FI104178B (fi)	1999-11-30
FI104178B1 true FI104178B1 (fi)	1999-11-30

Family

ID=8208088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI925790A FI104178B1 (fi)	1991-12-20	1992-12-18	17-spirofuran-3'-ylideenisteroidit

Country Status (17)

Country	Link
US (1)	US5292878A (fi)
EP (1)	EP0549041B1 (fi)
JP (1)	JP3462515B2 (fi)
KR (1)	KR100287513B1 (fi)
AT (1)	ATE128983T1 (fi)
AU (1)	AU655858B2 (fi)
CA (1)	CA2084431C (fi)
DE (1)	DE69205405T2 (fi)
DK (1)	DK0549041T3 (fi)
ES (1)	ES2081040T3 (fi)
FI (1)	FI104178B1 (fi)
GR (1)	GR3018630T3 (fi)
HK (1)	HK1002033A1 (fi)
MX (1)	MX9207394A (fi)
NO (1)	NO302525B1 (fi)
NZ (1)	NZ245520A (fi)
ZA (1)	ZA929315B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
CN1281363A (zh) *	1997-11-14	2001-01-24	阿克佐诺贝尔公司	孕激素-抗孕激素体系
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
WO1999061055A1 (en)	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
SK15502001A3 (sk) *	1999-04-29	2002-03-05	Akzo Nobel N. V.	Použitie Org 33245
US6043235A (en) *	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) *	2004-01-08	2008-09-16	Topside Research, Llc	Switch for bus optimization
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
CA2789097C (en)	2005-04-28	2017-02-21	Proteus Digital Health, Inc.	Pharma-informatics system
WO2007035716A2 (en)	2005-09-16	2007-03-29	Raptor Pharmaceutical Inc.	Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
AU2007217095B2 (en) *	2006-02-17	2012-05-03	Janssen Pharmaceutica N.V.	17-phosphorous steroid derivatives useful as progesterone receptor modulators
WO2007098381A2 (en) *	2006-02-17	2007-08-30	Janssen Pharmaceutica N.V.	11-phosphorous steroid derivatives useful as progesterone receptor modulators
HUE036870T2 (hu)	2006-10-24	2018-08-28	Repros Therapeutics Inc	Az endometriális proliferáció elnyomására szolgáló készítmények és módszerek
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
NZ616673A (en)	2009-02-20	2014-08-29	To Bbb Holding B V	Glutathione-based drug delivery system
US8673968B2 (en) *	2009-04-06	2014-03-18	Evestra, Inc.	Progesterone antagonists
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN101926806A (zh) *	2009-06-24	2010-12-29	天津金耀集团有限公司	一种17磷类雌甾化合物在制备紧急避孕药物中的应用
US20130018027A1 (en)	2010-03-22	2013-01-17	Repros Therapeutics Inc.	Compositions and methods for non-toxic delivery of antiprogestins
US20130272956A1 (en) *	2010-06-17	2013-10-17	Franciscus Theodorus Leonardus Brands	(11beta, 17alpha)-11-(4-(2-11C-ACETYL)PHENYL)-17,23-EPOXY-19,24-DINORCHOLA-4,9,20-TRIEN-3-ONE
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3461090D1 (en) *	1983-02-18	1986-12-04	Schering Ag	11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
EP0254341B1 (en) *	1986-07-23	1990-01-03	Akzo N.V.	Novel 18-phenyloestrane derivatives
IE60780B1 (en) *	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
EP0289073B1 (en) *	1987-04-24	1991-11-27	Akzo N.V.	Novel 11-aryloestrane and 11-arylpregnane derivatives
ES2053714T3 (es) *	1987-12-12	1994-08-01	Akzo Nv	Proceso para la preparacion de 11-arilesteroides.

1992
- 1992-12-01 ZA ZA929315A patent/ZA929315B/xx unknown
- 1992-12-03 CA CA002084431A patent/CA2084431C/en not_active Expired - Fee Related
- 1992-12-11 AU AU30093/92A patent/AU655858B2/en not_active Ceased
- 1992-12-15 DK DK92203923.5T patent/DK0549041T3/da active
- 1992-12-15 AT AT92203923T patent/ATE128983T1/de not_active IP Right Cessation
- 1992-12-15 EP EP92203923A patent/EP0549041B1/en not_active Expired - Lifetime
- 1992-12-15 ES ES92203923T patent/ES2081040T3/es not_active Expired - Lifetime
- 1992-12-15 DE DE69205405T patent/DE69205405T2/de not_active Expired - Fee Related
- 1992-12-15 NO NO924857A patent/NO302525B1/no unknown
- 1992-12-17 KR KR1019920024581A patent/KR100287513B1/ko not_active Expired - Fee Related
- 1992-12-17 MX MX9207394A patent/MX9207394A/es not_active IP Right Cessation
- 1992-12-18 JP JP33883092A patent/JP3462515B2/ja not_active Expired - Fee Related
- 1992-12-18 FI FI925790A patent/FI104178B1/fi active
- 1992-12-18 NZ NZ245520A patent/NZ245520A/en unknown
- 1992-12-21 US US07/994,039 patent/US5292878A/en not_active Expired - Lifetime
1996
- 1996-01-10 GR GR960400050T patent/GR3018630T3/el unknown
1998
- 1998-02-11 HK HK98101028A patent/HK1002033A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ245520A (en)	1995-02-24
FI925790L (fi)	1993-06-21
NO924857D0 (no)	1992-12-15
HK1002033A1 (en)	1998-07-24
NO302525B1 (no)	1998-03-16
EP0549041B1 (en)	1995-10-11
ZA929315B (en)	1993-05-24
CA2084431C (en)	2003-04-08
DE69205405D1 (de)	1995-11-16
NO924857L (no)	1993-06-21
AU3009392A (en)	1993-06-24
ATE128983T1 (de)	1995-10-15
EP0549041A1 (en)	1993-06-30
FI104178B (fi)	1999-11-30
JPH05255380A (ja)	1993-10-05
DK0549041T3 (da)	1996-01-29
JP3462515B2 (ja)	2003-11-05
DE69205405T2 (de)	1996-05-09
US5292878A (en)	1994-03-08
MX9207394A (es)	1993-07-30
FI925790A0 (fi)	1992-12-18
KR100287513B1 (ko)	2001-05-02
AU655858B2 (en)	1995-01-12
GR3018630T3 (en)	1996-04-30
CA2084431A1 (en)	1993-06-21
ES2081040T3 (es)	1996-02-16

Publication	Publication Date	Title
FI104178B1 (fi)	1999-11-30	17-spirofuran-3'-ylideenisteroidit
ATE176237T1 (de)	1999-02-15	Sphingoglycolipid und verwendung davon
SE9100342D0 (sv)	1991-02-04	Novel steroid esters
FI955108A0 (fi)	1995-10-26	Steroideja, jotka sisältävät 17-spiromtyleenilaktoni- tai laktoliryhmän
ATE229968T1 (de)	2003-01-15	Diagnostisches mittel zur glykostoffwechselfunktion
NO307447B1 (no)	2000-04-10	Anvendelse av et pregnanderivat
FI821486A0 (fi)	1982-04-28	4'-halogensubstituerade sakkarosderivater
ZA907639B (en)	1991-07-31	Benzanilides
FI823458A0 (fi)	1982-10-11	Substituerade tiazolidinylestrar av mineralsyror
DK0381989T3 (da)	1992-03-23	4-epi-4-amino-anthracycliner
FR2362148A1 (fr)	1978-03-17	Composes silices polyethyleniques
FR2501676B1 (fi)	1985-05-17
ATE73136T1 (de)	1992-03-15	Verfahren zur herstellung von 6alpha, 9alphadifluor-11beta, 17alpha-dihydroxy-16alpha-methyl4-pregnen-3,20-dion und dessen derivate.
IL117497A (en)	1999-12-22	17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
ATE116655T1 (de)	1995-01-15	2-acyloxy-4-morpholinyl-anthracyclin.
FI812777L (fi)	1982-03-14	Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
FR2493846B1 (fi)	1983-01-21
DE69615814D1 (de)	2001-11-15	Uch-15-verbindungen

Legal Events

Date	Code	Title	Description
2006-12-07	PC	Transfer of assignment of patent	Owner name: N.V. ORGANON Free format text: N.V. ORGANON

Date

Code

Title

Description

2006-12-07

Transfer of assignment of patent

Owner name: N.V. ORGANON

Free format text: N.V. ORGANON