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ES8900093A1 - Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano - Google Patents

Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Info

Publication number
ES8900093A1
ES8900093A1 ES557774A ES557774A ES8900093A1 ES 8900093 A1 ES8900093 A1 ES 8900093A1 ES 557774 A ES557774 A ES 557774A ES 557774 A ES557774 A ES 557774A ES 8900093 A1 ES8900093 A1 ES 8900093A1
Authority
ES
Spain
Prior art keywords
group
preparation
compounds
macrolide antibiotics
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557774A
Other languages
English (en)
Other versions
ES557774A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858510944A external-priority patent/GB8510944D0/en
Priority claimed from GB858510942A external-priority patent/GB8510942D0/en
Priority claimed from GB858510943A external-priority patent/GB8510943D0/en
Priority claimed from GB868606103A external-priority patent/GB8606103D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES557774A0 publication Critical patent/ES557774A0/es
Publication of ES8900093A1 publication Critical patent/ES8900093A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LOS COMPUESTOS ANALOGOS 23-CETONA, 23-DESOXI Y 23-HIDROXILO O HIDROXILO SUSTITUIDO DE LOS ANTIBIOTICOS S 541 QUE TIENEN UN GRUPO HIDROXILO O HIDROXILO SUSTITUIDO EN LA POSICION 5, DE FORMULA GENERAL (I), SE PREPARAN ETERIFICANDO UN COMPUESTO CORRESPONDIENTE EN EL QUE R7 ES UN ATOMO DE HIDROGENO, CON UN REACTIVO R7Y DONDE Y ES UN GRUPO ELIMINABLE (COMO UN ATOMO DE HALOGENO, UN GRUPO HIDROCARBILSULFONILOXI O HALOALCANOILOXI). ESTOS COMPUESTOS SON UTILES COMO ANTIBIOTICOS Y/O COMO COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE OTROS COMPUESTOS ACTIVOS Y/O EN EL AISLAMIENTO Y LA PURIFICACION DE COMPUESTOS ANTIBIOTICOS S 541. EN CUANTO A SU ACTIVIDAD ANTIBIOTICA PUEDEN UTILIZARSE POR SU ACTIVIDAD ANTI-ECTOPARASITOS Y ANTI-ENDOPARASITOS QUE INFECTAN A SERES HUMANOS Y A DIVERSIDAD DE ANIMALES. PUEDEN FORMULARSE PARA ADMINISTRACION DE CUALQUIER MANERA CONVENIENTE PARA USO EN VETERINARIA O MEDICINA HUMANA. *FORMULA*
ES557774A 1985-04-30 1987-10-30 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano Expired ES8900093A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858510944A GB8510944D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510942A GB8510942D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB858510943A GB8510943D0 (en) 1985-04-30 1985-04-30 Chemical compounds
GB868606103A GB8606103D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (2)

Publication Number Publication Date
ES557774A0 ES557774A0 (es) 1988-12-01
ES8900093A1 true ES8900093A1 (es) 1988-12-01

Family

ID=27449656

Family Applications (4)

Application Number Title Priority Date Filing Date
ES554444A Expired ES8802229A1 (es) 1985-04-30 1986-04-28 Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
ES557517A Expired ES8802522A1 (es) 1985-04-30 1987-04-30 Un procedimiento para preparar nuevos derivados macrociclicos de lactona
ES557774A Expired ES8900093A1 (es) 1985-04-30 1987-10-30 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano
ES557851A Expired ES9000023A1 (es) 1985-04-30 1988-09-01 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES554444A Expired ES8802229A1 (es) 1985-04-30 1986-04-28 Un procedimiento para preparar nuevos derivados lactonicos macrociclicos.
ES557517A Expired ES8802522A1 (es) 1985-04-30 1987-04-30 Un procedimiento para preparar nuevos derivados macrociclicos de lactona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557851A Expired ES9000023A1 (es) 1985-04-30 1988-09-01 Un procedimiento para preparar nuevos antibioticos macrociclicos que contienen anillos de dihidrobenzofurano y de pirano

Country Status (25)

Country Link
US (1) US4978675A (es)
JP (1) JPH0819132B2 (es)
KR (1) KR930011282B1 (es)
AT (1) AT397095B (es)
AU (1) AU596586B2 (es)
BE (1) BE904709A (es)
CA (1) CA1335368C (es)
CH (1) CH675124A5 (es)
DE (1) DE3614549C2 (es)
DK (1) DK160992C (es)
ES (4) ES8802229A1 (es)
FR (1) FR2587344B1 (es)
GB (1) GB2176182B (es)
GE (3) GEP19971046B (es)
HU (1) HU200771B (es)
IE (1) IE59070B1 (es)
IL (1) IL78621A (es)
LU (1) LU86412A1 (es)
LV (2) LV10777B (es)
NL (1) NL193420C (es)
NZ (1) NZ215997A (es)
PH (1) PH23386A (es)
PT (1) PT82485B (es)
RU (1) RU2004545C1 (es)
SE (1) SE503571C2 (es)

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SE502748C2 (sv) * 1984-09-14 1995-12-18 American Cyanamid Co Kemiska föreningar och förfarande för deras framställning
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
EP0215654B1 (en) * 1985-09-13 1995-03-15 American Cyanamid Company Macrolide antibiotics and their preparation
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
US5185456A (en) * 1986-03-12 1993-02-09 American Cyanamid Company Macrolide compounds
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SE8701019L (sv) * 1986-03-12 1987-09-13 Glaxo Group Ltd Makrolidforening
CA1288425C (en) * 1986-03-12 1991-09-03 Michael V.J. Ramsay Macrolide compounds
ES2061487T3 (es) * 1986-03-12 1994-12-16 American Cyanamid Co Compuestos macrolidos.
US5336789A (en) * 1986-03-12 1994-08-09 American Cyanamid Company Macrolide compounds
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
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US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
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DE3750355T2 (de) * 1986-09-12 1995-04-06 American Cyanamid Co 23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen.
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
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US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
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US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
JPS6431776A (en) * 1987-07-28 1989-02-02 Sankyo Co Novel macrolide compound and production thereof
NZ226117A (en) * 1987-09-11 1990-01-29 American Cyanamid Co Preparation of 5-oh milbemycins from 5-keto milbemycins
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721376D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721373D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
CA1340771C (en) * 1987-11-09 1999-09-28 Shih-Jen Edward Lee Ethylated avermectins
GB8726384D0 (en) * 1987-11-11 1987-12-16 Coopers Animal Health Veterinary treatment
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8801908D0 (en) * 1988-01-28 1988-02-24 Glaxo Group Ltd Chemical compounds
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GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
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GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
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ES2052173T3 (es) * 1989-04-11 1994-07-01 Pfizer Composiciones inyectables que contienen 25-cyclohexil-avermectina b1.
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
US5055486A (en) * 1989-12-22 1991-10-08 American Cyanamid Company 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5290804A (en) * 1991-05-01 1994-03-01 Merck & Co., Inc. Anthelmintic milbemycin analogs of novel microorganisms
ES2131515T3 (es) * 1991-09-30 1999-08-01 Merck & Co Inc Formulados inyectables de accion prolongada que contienen aceite de ricino hidrogenado.
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
GB9408044D0 (en) * 1994-04-22 1994-06-15 Sod Conseils Rech Applic Conversion of ginkgolide c to ginkgolide b
DE19534366C2 (de) * 1995-09-15 2000-08-17 Asta Medica Ag Verfahren zur Herstellung von 2,3,4,6-Tetra-O-benzyl-D-glucopyranose und 2,3,4,6-Tetra-O-allyl-D-glucopyranose
NZ299460A (en) * 1995-09-29 1997-12-19 Sankyo Co 13-substituted milbemycin 5-oxime derivatives; veterinary pesticides
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NZ552040A (en) * 2006-12-13 2009-04-30 Bomac Research Ltd Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
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JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
EP0170006B1 (en) * 1984-06-05 1992-07-08 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
SE502748C2 (sv) * 1984-09-14 1995-12-18 American Cyanamid Co Kemiska föreningar och förfarande för deras framställning
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
GB8610631D0 (en) 1986-06-04
ES557851A0 (es) 1990-05-01
DK196586D0 (da) 1986-04-29
GB2176182B (en) 1989-02-01
GEP20001917B (en) 2000-01-05
DE3614549A1 (de) 1987-01-02
LV10314B (en) 1995-08-20
SE8601998D0 (sv) 1986-04-29
JPH0819132B2 (ja) 1996-02-28
FR2587344B1 (fr) 1991-04-05
IL78621A (en) 1991-06-30
LV10777B (en) 1996-04-20
NZ215997A (en) 1989-06-28
RU2004545C1 (ru) 1993-12-15
ES554444A0 (es) 1988-04-16
PH23386A (en) 1989-07-26
IE861127L (en) 1986-10-30
JPS61280496A (ja) 1986-12-11
US4978675A (en) 1990-12-18
DE3614549C2 (de) 1998-03-12
AU596586B2 (en) 1990-05-10
ES9000023A1 (es) 1990-05-01
KR930011282B1 (ko) 1993-11-29
ES557774A0 (es) 1988-12-01
CH675124A5 (es) 1990-08-31
KR860008205A (ko) 1986-11-14
GEP19971046B (en) 1997-11-26
IL78621A0 (en) 1986-08-31
LV10777A (lv) 1995-08-20
NL193420C (nl) 1999-10-04
CA1335368C (en) 1995-04-25
DK160992C (da) 1991-11-11
DK196586A (da) 1986-10-31
ATA115486A (de) 1993-06-15
GB2176182A (en) 1986-12-17
GEP19970833B (en) 1997-02-10
IE59070B1 (en) 1993-12-15
ES557517A0 (es) 1988-07-16
PT82485A (en) 1986-05-01
SE8601998L (sv) 1986-10-31
HU200771B (en) 1990-08-28
FR2587344A1 (fr) 1987-03-20
ES8802522A1 (es) 1988-07-16
HUT46012A (en) 1988-09-28
NL193420B (nl) 1999-06-01
PT82485B (pt) 1988-03-03
DK160992B (da) 1991-05-13
LV10314A (lv) 1994-10-20
AT397095B (de) 1994-01-25
NL8601103A (nl) 1986-11-17
AU5676786A (en) 1986-11-06
LU86412A1 (fr) 1986-11-05
SE503571C2 (sv) 1996-07-08
BE904709A (fr) 1986-10-30
ES8802229A1 (es) 1988-04-16

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