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ES8802015A1 - Procedimiento para preparar alfa-aminoacidos sustituidos - Google Patents

Procedimiento para preparar alfa-aminoacidos sustituidos

Info

Publication number
ES8802015A1
ES8802015A1 ES555559A ES555559A ES8802015A1 ES 8802015 A1 ES8802015 A1 ES 8802015A1 ES 555559 A ES555559 A ES 555559A ES 555559 A ES555559 A ES 555559A ES 8802015 A1 ES8802015 A1 ES 8802015A1
Authority
ES
Spain
Prior art keywords
amino acids
substituted alpha
procedure
formula
prepare substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555559A
Other languages
English (en)
Other versions
ES555559A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848408059A external-priority patent/GB8408059D0/en
Priority claimed from GB848421091A external-priority patent/GB8421091D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES555559A0 publication Critical patent/ES555559A0/es
Publication of ES8802015A1 publication Critical patent/ES8802015A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PREPARACION DE ALFA-AMINOACIDOS SUSTITUIDOS DE FORMULA (I) EN LA QUE M, N F 1, 2 O 3 Y R1, AM XKKK E Y SON ENTRE OTROS, HIDROGENO, GRUPO AMINO, SULFINILO Y UN GRUPO ACIDO QUE CONTIENE FOSFORO, RESPECTIVAMENTE. SE OXIDA UN COMPUESTO DE FORMULA (II) EN LA QUE R1, A, M, N E Y TIENEN LOS SIGNIFICADOS ANTERIORES, Y XK SIGNIFICA -S-, CON UN AGENTE DE OXIDACION DE PERYODATO DE SODIO, ENTRE OTROS, A UNA TEMPERATURA ENTRE 0JC Y TEMPERATURA AMBIENTE, Y SE ELIMINA CUALQUIER GRUPO PROTECTOR PRESENTE DEL GRUPO AMINO. POR SUS ACTIVIDADES SOBRE EL SISTEMA NERVIOSO CENTRAL TIENE APLICACIONES FARMACOLOGICAS, PREFERENTEMENTE COMO ANTICONVULSIONANTE Y COMO AGENTE PROTECTOR CONTRA LAS CONDICIONES HIPOXICAS.
ES555559A 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos Expired ES8802015A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848408059A GB8408059D0 (en) 1984-03-29 1984-03-29 Organic compounds
GB848421091A GB8421091D0 (en) 1984-08-20 1984-08-20 Organic compounds

Publications (2)

Publication Number Publication Date
ES555559A0 ES555559A0 (es) 1988-03-16
ES8802015A1 true ES8802015A1 (es) 1988-03-16

Family

ID=26287523

Family Applications (3)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (es) 1984-03-29 1985-03-28 Procedimiento para preparar alfa-aminoacidos sustituidos
ES555560A Expired ES8706622A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos
ES555559A Expired ES8802015A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (es) 1984-03-29 1985-03-28 Procedimiento para preparar alfa-aminoacidos sustituidos
ES555560A Expired ES8706622A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos

Country Status (16)

Country Link
AU (1) AU4042585A (es)
BE (1) BE902040A (es)
DE (1) DE3510858A1 (es)
DK (1) DK139185A (es)
ES (3) ES8704957A1 (es)
FI (1) FI851234A7 (es)
FR (1) FR2562076A1 (es)
GB (1) GB2156818B (es)
GR (1) GR850770B (es)
HU (1) HUT40447A (es)
IL (1) IL74734A0 (es)
IT (1) IT1199964B (es)
LU (1) LU85826A1 (es)
NL (1) NL8500847A (es)
PT (1) PT80178B (es)
SE (1) SE8501548L (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US5217963A (en) * 1985-05-24 1993-06-08 Ciba-Geigy Corporation Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D-aspartate receptor blockade
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
IT1216096B (it) * 1988-03-15 1990-02-22 Farmaceutica Italiana S P A S L_piroglutamil_l_cisteina, dipeptide ad elevata attivita'anticatarattogena e composizioni farmaceutiche che lo contengono.
EP0436612A4 (en) * 1988-09-30 1992-05-20 Australian Commercial Research & Development Limited Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
JPH03236315A (ja) * 1989-12-05 1991-10-22 Nippon Oil & Fats Co Ltd 抗精神病薬
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
IT1249650B (it) * 1991-05-29 1995-03-09 Poli Ind Chimica Spa N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico
IT1256178B (it) * 1992-11-30 1995-11-29 Lorenzo Ferrari Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
DE4433555B4 (de) * 1994-09-07 2005-04-28 Guenther Oehme Wasserlösliche chirale und achirale Phosphine, Verfahren zu ihrer Herstellung und ihre Verwendung
WO2002022568A1 (de) 2000-09-14 2002-03-21 Grünenthal GmbH β-THIO-AMINOSÄUREN
DE10045831A1 (de) * 2000-09-14 2002-04-04 Gruenenthal Gmbh Thio-Aminosäuren
CA2458720A1 (en) * 2001-09-18 2003-03-27 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatment
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
WO2019048450A1 (en) 2017-09-08 2019-03-14 Ludwig-Maximilians-Universität München SULFOXIDE-BASED REAGENT FOR MASS SPECTROMETRY

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
ES8704957A1 (es) 1987-04-16
GB2156818A (en) 1985-10-16
GR850770B (es) 1985-07-23
FI851234A0 (fi) 1985-03-27
FI851234L (fi) 1985-09-30
ES555560A0 (es) 1987-07-01
IT8547877A1 (it) 1986-09-27
ES555559A0 (es) 1988-03-16
FI851234A7 (fi) 1985-09-30
IT8547877A0 (it) 1985-03-27
IT1199964B (it) 1989-01-05
HUT40447A (en) 1986-12-28
FR2562076A1 (fr) 1985-10-04
LU85826A1 (fr) 1985-12-12
DK139185D0 (da) 1985-03-27
PT80178A (en) 1985-04-01
SE8501548D0 (sv) 1985-03-28
AU4042585A (en) 1985-10-03
DE3510858A1 (de) 1985-10-10
GB2156818B (en) 1987-10-21
DK139185A (da) 1985-09-30
ES8706622A1 (es) 1987-07-01
ES541689A0 (es) 1987-04-16
GB8507794D0 (en) 1985-05-01
NL8500847A (nl) 1985-10-16
SE8501548L (sv) 1985-09-30
IL74734A0 (en) 1985-06-30
PT80178B (en) 1987-03-20
BE902040A (fr) 1985-09-30

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