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ES8704965A1 - Un procedimiento para la preparacion de un antibiotico de macrolida - Google Patents

Un procedimiento para la preparacion de un antibiotico de macrolida

Info

Publication number
ES8704965A1
ES8704965A1 ES551503A ES551503A ES8704965A1 ES 8704965 A1 ES8704965 A1 ES 8704965A1 ES 551503 A ES551503 A ES 551503A ES 551503 A ES551503 A ES 551503A ES 8704965 A1 ES8704965 A1 ES 8704965A1
Authority
ES
Spain
Prior art keywords
compound
formula
aza
reaction
homoerythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551503A
Other languages
English (en)
Other versions
ES551503A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/600,252 external-priority patent/US4512982A/en
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES8704965A1 publication Critical patent/ES8704965A1/es
Publication of ES551503A0 publication Critical patent/ES551503A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN EXCESO DE ACETATO AMONICO Y CIANOBOROHIDRURO SODICO PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LA QUE R1 ES METILO, R3 ES HIDROGENO Y R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN ALCANOL INFERIOR, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES551503A 1984-04-13 1986-01-31 Un procedimiento para la preparacion de un antibiotico de macrolida Expired ES8704965A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/600,252 US4512982A (en) 1984-04-13 1984-04-13 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US06/616,529 US4518590A (en) 1984-04-13 1984-06-04 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method

Publications (2)

Publication Number Publication Date
ES8704965A1 true ES8704965A1 (es) 1987-04-16
ES551503A0 ES551503A0 (es) 1987-04-16

Family

ID=27083554

Family Applications (3)

Application Number Title Priority Date Filing Date
ES542134A Expired ES8607335A1 (es) 1984-04-13 1985-04-11 Un procedimiento para la preparacion de un antibiotico de macrolida
ES551502A Expired ES8705458A1 (es) 1984-04-13 1986-01-31 Un procedimiento para la preparacion de un antibiotico de macrolida
ES551503A Expired ES8704965A1 (es) 1984-04-13 1986-01-31 Un procedimiento para la preparacion de un antibiotico de macrolida

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES542134A Expired ES8607335A1 (es) 1984-04-13 1985-04-11 Un procedimiento para la preparacion de un antibiotico de macrolida
ES551502A Expired ES8705458A1 (es) 1984-04-13 1986-01-31 Un procedimiento para la preparacion de un antibiotico de macrolida

Country Status (19)

Country Link
US (1) US4518590A (es)
EP (1) EP0159856B1 (es)
KR (1) KR860002111B1 (es)
AU (1) AU549235B2 (es)
CA (1) CA1234805A (es)
DE (1) DE3565267D1 (es)
DK (1) DK164785A (es)
EG (1) EG17459A (es)
ES (3) ES8607335A1 (es)
FI (1) FI851449L (es)
GR (1) GR850900B (es)
HU (1) HU195668B (es)
IE (1) IE57739B1 (es)
IL (1) IL74865A (es)
NO (1) NO161497C (es)
NZ (1) NZ211769A (es)
PH (1) PH21185A (es)
PT (1) PT80270B (es)
YU (3) YU62385A (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US4904644A (en) * 1988-08-03 1990-02-27 Schering Corporation Antimicrobial compound isolated from Actinomadura fulva subsp indica
DE69227713D1 (de) 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
DE69211845T2 (de) * 1991-04-09 1997-01-23 Abbott Lab Macrozyklische laktam-prokinetika
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
ES2104386T3 (es) * 1993-05-19 1997-10-01 Pfizer Compuesto intermedio para la acitromicina.
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
USRE38426E1 (en) * 1995-10-09 2004-02-10 Aventis Pharma S.A. 5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
CA2419873A1 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
CA2445306C (en) 2001-04-27 2008-02-12 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20060069047A1 (en) 2002-02-15 2006-03-30 Michael Burnet Antibiotic conjugates
GB0310992D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4180654A (en) * 1978-01-03 1979-12-25 Pfizer Inc. 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor

Also Published As

Publication number Publication date
IL74865A0 (en) 1985-07-31
EP0159856A2 (en) 1985-10-30
IL74865A (en) 1987-12-31
NO161497C (no) 1989-08-23
YU126787A (en) 1988-02-29
NO161497B (no) 1989-05-16
PT80270B (pt) 1987-10-20
FI851449A7 (fi) 1985-10-14
ES8607335A1 (es) 1986-06-16
YU62385A (en) 1988-02-29
DK164785A (da) 1985-12-10
AU549235B2 (en) 1986-01-23
FI851449A0 (fi) 1985-04-11
ES542134A0 (es) 1986-06-16
IE57739B1 (en) 1993-03-24
HUT37629A (en) 1986-01-23
PT80270A (en) 1985-05-01
AU4107085A (en) 1985-10-17
NZ211769A (en) 1987-10-30
DK164785D0 (da) 1985-04-12
ES551502A0 (es) 1987-05-01
YU126887A (en) 1988-02-29
EP0159856A3 (en) 1986-03-19
PH21185A (en) 1987-08-12
GR850900B (es) 1985-11-25
KR850007435A (ko) 1985-12-04
US4518590A (en) 1985-05-21
ES8705458A1 (es) 1987-05-01
ES551503A0 (es) 1987-04-16
HU195668B (en) 1988-06-28
NO851466L (no) 1985-10-14
FI851449L (fi) 1985-10-14
DE3565267D1 (en) 1988-11-03
IE850912L (en) 1985-10-13
KR860002111B1 (ko) 1986-11-26
EG17459A (en) 1992-12-30
CA1234805A (en) 1988-04-05
EP0159856B1 (en) 1988-09-28

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