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ES8801925A1 - Procedimiento para la fabricacion de derivados gangliosidos - Google Patents

Procedimiento para la fabricacion de derivados gangliosidos

Info

Publication number
ES8801925A1
ES8801925A1 ES557807A ES557807A ES8801925A1 ES 8801925 A1 ES8801925 A1 ES 8801925A1 ES 557807 A ES557807 A ES 557807A ES 557807 A ES557807 A ES 557807A ES 8801925 A1 ES8801925 A1 ES 8801925A1
Authority
ES
Spain
Prior art keywords
procedure
manufacture
ganglioside derivatives
ganglioside
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557807A
Other languages
English (en)
Other versions
ES557807A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Publication of ES557807A0 publication Critical patent/ES557807A0/es
Publication of ES8801925A1 publication Critical patent/ES8801925A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE TRATA UN DERIVADO DE LA AMIDA DE UN GANGLIOSIDO CON UN AGENTE ACILANTE, COMO UN ACIDO CARBOXILICO C1-10, POR EJEMPLO, ACIDO ACETICO; O AROMATICO, POR EJEMPLO, ACIDO BENZOICO; O COMO UN ANHIDRIDO; EN PRESENCIA DE UNA BASE, COMO UNA AMINA TERCIARIA.
ES557807A 1984-07-03 1987-12-16 Procedimiento para la fabricacion de derivados gangliosidos Expired ES8801925A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48492/84A IT1199116B (it) 1984-07-03 1984-07-03 Derivati di gangliosidi

Publications (2)

Publication Number Publication Date
ES557807A0 ES557807A0 (es) 1988-03-16
ES8801925A1 true ES8801925A1 (es) 1988-03-16

Family

ID=11266890

Family Applications (3)

Application Number Title Priority Date Filing Date
ES544574A Expired ES8706711A1 (es) 1984-07-03 1985-06-26 Procedimiento para la fabricacion de nuevos derivados gan- gliosidos
ES552826A Expired ES8802055A1 (es) 1984-07-03 1986-02-28 Procedimiento para la fabricacion de derivados gangliosidos
ES557807A Expired ES8801925A1 (es) 1984-07-03 1987-12-16 Procedimiento para la fabricacion de derivados gangliosidos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES544574A Expired ES8706711A1 (es) 1984-07-03 1985-06-26 Procedimiento para la fabricacion de nuevos derivados gan- gliosidos
ES552826A Expired ES8802055A1 (es) 1984-07-03 1986-02-28 Procedimiento para la fabricacion de derivados gangliosidos

Country Status (31)

Country Link
US (2) US4713374A (es)
EP (1) EP0167449B1 (es)
JP (1) JPS6163691A (es)
KR (1) KR880001232B1 (es)
CN (2) CN1021333C (es)
AR (1) AR242219A1 (es)
AT (1) ATE58739T1 (es)
AU (1) AU578706B2 (es)
BE (1) BE902750A (es)
CA (1) CA1263954A (es)
CH (1) CH670645A5 (es)
DE (1) DE3580710D1 (es)
DK (2) DK289885A (es)
ES (3) ES8706711A1 (es)
FI (1) FI84074C (es)
FR (1) FR2567131B1 (es)
GR (1) GR851573B (es)
HU (2) HUT38652A (es)
IE (1) IE59376B1 (es)
IL (1) IL75640A0 (es)
IN (1) IN164786B (es)
IT (1) IT1199116B (es)
LU (1) LU85972A1 (es)
MX (1) MX163384B (es)
NO (1) NO164545C (es)
NZ (1) NZ212540A (es)
PH (1) PH27021A (es)
PL (2) PL151829B1 (es)
PT (1) PT80724B (es)
YU (1) YU46603B (es)
ZA (1) ZA854807B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177863B (it) * 1984-07-03 1987-08-26 Fidia Farmaceutici Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
JPS6168418A (ja) * 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
US4769362A (en) * 1985-10-01 1988-09-06 Trustees Of Boston University Increased vascular perfusion following administration of lipids
FR2598434B1 (fr) * 1986-05-12 1988-09-16 Pf Medicament Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae
EP0255717A3 (en) * 1986-08-06 1990-12-05 Mect Corporation Ganglioside related compounds and method of producing the same
JPS6368526A (ja) * 1986-09-11 1988-03-28 Mect Corp シアリルグリセライドからなる神経障害疾患治療剤
NZ222192A (en) * 1986-10-20 1991-03-26 Kanto Ishi Pharma Co Ltd Glycolipid containing n-glycolylneuraminic acid, and preparation thereof
FR2614306B1 (fr) * 1987-04-22 1989-07-28 Pf Medicament Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant.
JP2517293B2 (ja) * 1987-06-25 1996-07-24 メクト株式会社 細胞、組織修復剤
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
US5169636A (en) * 1988-03-17 1992-12-08 Nippon Fine Chemical Co., Ltd. Liposomes
IT1224513B (it) * 1988-07-19 1990-10-04 Fidia Farmaceutici Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US6407072B1 (en) * 1988-12-02 2002-06-18 Fidia S.P.A. Lysoganglioside derivatives
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
IN172427B (es) * 1989-11-14 1993-07-24 Fidia Spa
DK238190D0 (da) * 1990-10-03 1990-10-03 Lundbeck & Co As H Depotderivater
IT1251540B (it) * 1991-05-31 1995-05-17 Fidia Spa Uso di un derivato gangliosidico.
WO1993002686A1 (en) * 1991-07-31 1993-02-18 The Regents Of The University Of California Gangliosides with immunosuppressive ceramide moieties
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
AU674293B2 (en) * 1991-11-11 1996-12-19 Hans Goran Magnusson Ganglioside analogs
IT1254706B (it) 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
DE4204907A1 (de) * 1992-02-14 1993-08-19 Reutter Werner Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
US6468531B1 (en) * 1993-09-09 2002-10-22 Duke University Method of promoting cellular function
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives
IT1302530B1 (it) * 1998-12-16 2000-09-05 Fidia Spa In Amministrazione S Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1.
AU2002330968B2 (en) 2001-08-17 2007-03-22 Neose Technologies, Inc. Chemo-enzymatic synthesis of sialylated oligosaccharides
US7842677B2 (en) 2001-08-29 2010-11-30 Seneb Biosciences, Inc. Synthetic ganglioside derivatives and compositions thereof
WO2004080960A2 (en) 2003-03-06 2004-09-23 Neose Technologies Inc. Methods and compositions for the enzymatic synthesis of gangliosides
JP2007003173A (ja) * 2005-05-26 2007-01-11 Matsushita Electric Ind Co Ltd 冷蔵庫
US7943750B2 (en) 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
JP5702600B2 (ja) 2007-07-03 2015-04-15 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド オリゴシアル酸誘導体、製造方法および免疫学的使用
WO2009006591A1 (en) * 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-n-acetylase and methods for using the same
CA2692417C (en) 2007-07-03 2017-03-21 Children's Hospital & Research Center At Oakland Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
US20120035120A1 (en) 2009-03-25 2012-02-09 Seneb Biosciences, Inc. Glycolipids as treatment for disease
ES2581523T3 (es) 2009-09-01 2016-09-06 Lz Therapeutics, Inc. Producción en cultivo celular (no bovino, no porcino) de GM1
MX2014008797A (es) 2012-01-20 2014-10-30 Garnet Biotherapeutics Inc Metodos para la produccion gangliosidos.
WO2014144953A1 (en) * 2013-03-15 2014-09-18 Garnet Biotherapeutics, Inc. Ganglioside compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098995A (en) * 1976-07-12 1978-07-04 American Cyanamid Company Polygalactosido-sucrose poly(h-)sulfate salts
FR2478104B1 (fr) * 1980-03-17 1986-08-08 Merieux Inst Nouveaux derives de gangliosides, leur preparation et leur application
US4435389A (en) * 1980-07-07 1984-03-06 Kabushiki Kaisha Yakult Honsha Composition for promoting growth of bifidobacteria
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4476119A (en) * 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4469795A (en) * 1981-08-26 1984-09-04 Edward Ginns Radioassay for monosialoglycosphingolipid (GM1) ganglioside concentration
NL8104293A (nl) * 1981-09-17 1983-04-18 Ihc Holland Nv Werkwijze voor het opzuigen van grond of slib met een sleepzuiger alsmede sleepzuiger voor het toepassen van de werkwijze.
CH658458A5 (fr) * 1981-12-17 1986-11-14 Lucchini Lab Sa Procede pour l'obtention du lacto-n-norhexaosyl ceramide.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi

Also Published As

Publication number Publication date
HU199860B (en) 1990-03-28
US4713374A (en) 1987-12-15
EP0167449A2 (en) 1986-01-08
PT80724B (pt) 1987-08-19
IN164786B (es) 1989-06-03
IT1199116B (it) 1988-12-30
NO164545B (no) 1990-07-09
PL254207A1 (en) 1987-02-09
EP0167449B1 (en) 1990-11-28
JPS6163691A (ja) 1986-04-01
CN1021333C (zh) 1993-06-23
YU46603B (sh) 1994-01-20
KR860000310A (ko) 1986-01-27
DK78592A (da) 1992-06-12
PL151829B1 (en) 1990-10-31
EP0167449A3 (en) 1987-10-21
PL261619A1 (en) 1988-02-04
ES552826A0 (es) 1988-04-01
AU578706B2 (en) 1988-11-03
ATE58739T1 (de) 1990-12-15
IE851608L (en) 1986-01-03
NO852565L (no) 1986-01-06
ES557807A0 (es) 1988-03-16
GR851573B (es) 1985-11-25
CN85104937A (zh) 1987-01-07
NZ212540A (en) 1989-01-27
FR2567131B1 (fr) 1991-06-07
ZA854807B (en) 1987-09-30
FI84074C (fi) 1991-10-10
DK78592D0 (da) 1992-06-12
FI852515A0 (fi) 1985-06-26
IE59376B1 (en) 1994-02-23
DE3580710D1 (de) 1991-01-10
HUT38652A (en) 1986-06-30
ES8706711A1 (es) 1987-07-01
YU107285A (en) 1988-08-31
CA1263954A (en) 1989-12-19
CN1055741A (zh) 1991-10-30
CH670645A5 (es) 1989-06-30
ES544574A0 (es) 1987-07-01
DK289885D0 (da) 1985-06-26
IT8448492A0 (it) 1984-07-03
DK289885A (da) 1986-01-04
FR2567131A1 (fr) 1986-01-10
NO164545C (no) 1990-10-17
US4849413A (en) 1989-07-18
LU85972A1 (fr) 1986-01-22
FI852515L (fi) 1986-01-04
PL151289B1 (en) 1990-08-31
CN1021574C (zh) 1993-07-14
FI84074B (fi) 1991-06-28
AR242219A1 (es) 1993-03-31
IL75640A0 (en) 1985-10-31
IT8448492A1 (it) 1986-01-03
ES8802055A1 (es) 1988-04-01
AU4420885A (en) 1986-01-02
MX163384B (es) 1992-05-07
PH27021A (en) 1993-02-01
BE902750A (fr) 1985-12-30
KR880001232B1 (ko) 1988-07-12
PT80724A (en) 1985-07-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201