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ES8801198A1 - Un procedimiento para la preparacion de delta 22 o delta 23 -26,-26,26,27,27,27-hexafluoro-1alfa,25-dihidroxicolecalci- ferol - Google Patents

Un procedimiento para la preparacion de delta 22 o delta 23 -26,-26,26,27,27,27-hexafluoro-1alfa,25-dihidroxicolecalci- ferol

Info

Publication number
ES8801198A1
ES8801198A1 ES548910A ES548910A ES8801198A1 ES 8801198 A1 ES8801198 A1 ES 8801198A1 ES 548910 A ES548910 A ES 548910A ES 548910 A ES548910 A ES 548910A ES 8801198 A1 ES8801198 A1 ES 8801198A1
Authority
ES
Spain
Prior art keywords
preparation
aryl
methyl
formula
treat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548910A
Other languages
English (en)
Other versions
ES548910A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8801198A1 publication Critical patent/ES8801198A1/es
Publication of ES548910A0 publication Critical patent/ES548910A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/44—Halogenated unsaturated alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DEL DELTA22 O DELTA23-26,26,26,27,27,27-HEXAFLUORO-1ALFA,25-DIHIDROXICOLECALCIFEROL. COMPRENDE: A) HACER REACCIONAR A 1R-1B(RX),3AA,4B,7AB OCTAHIDRO-1-6,6,6-TRIFLUORO-5-TRIMETILSILILOXI-5-TRIFLUOROMETIL-1-METIL-2-HEXENIL-7-A-METIL-H-INDEN-4-ONA DE FORMULA (II) CON OXIDO DE 35-(3A,5B,Z)-2-2-METILEN-3,5-BIS) (1,1-DIMETILETIL) DIMETILSILILOXI CICLOHEXILIDEN ETILDIFENILFOSFINA, EN TETRAHIDROFURANO Y EN ATMOSFERA INERTE; B) TRATAR AL COMPUESTO OBTENIDO EN A) CON FENORURO DE TETRABUTILAMONIO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R1, R2, R3, ALQUILO INFERIOR O ARILO Y X ARILO. SE UTILIZA PARA TRATAR LA OSTEOPOROSIS Y OSTEODISTROFIA.
ES548910A 1984-11-16 1985-11-15 Un procedimiento para la preparacion de delta 22 o delta 23 -26,-26,26,27,27,27-hexafluoro-1alfa,25-dihidroxicolecalci- ferol Expired ES8801198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/672,059 US4613594A (en) 1984-11-16 1984-11-16 Fluorinated vitamin D3 compounds

Publications (2)

Publication Number Publication Date
ES8801198A1 true ES8801198A1 (es) 1987-12-16
ES548910A0 ES548910A0 (es) 1987-12-16

Family

ID=24696990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548910A Expired ES8801198A1 (es) 1984-11-16 1985-11-15 Un procedimiento para la preparacion de delta 22 o delta 23 -26,-26,26,27,27,27-hexafluoro-1alfa,25-dihidroxicolecalci- ferol

Country Status (21)

Country Link
US (1) US4613594A (es)
EP (1) EP0182298B1 (es)
JP (1) JPS61122237A (es)
KR (1) KR930007993B1 (es)
AR (1) AR242767A1 (es)
AT (1) ATE48412T1 (es)
AU (1) AU588012B2 (es)
CA (1) CA1286693C (es)
DE (1) DE3574587D1 (es)
DK (1) DK159652C (es)
ES (1) ES8801198A1 (es)
FI (1) FI84599C (es)
HU (1) HU194162B (es)
IE (1) IE58851B1 (es)
IL (1) IL77052A (es)
MC (1) MC1709A1 (es)
NO (1) NO162906C (es)
NZ (1) NZ214175A (es)
PH (1) PH21540A (es)
PT (1) PT81502B (es)
ZA (1) ZA858151B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63196556A (ja) * 1987-02-10 1988-08-15 Taisho Pharmaceut Co Ltd 含フツ素ビタミンｄ誘導体
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5278155A (en) * 1991-06-05 1994-01-11 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
DK0521550T3 (da) * 1991-07-05 1996-11-04 Duphar Int Res Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
CN117088798A (zh) * 2023-09-04 2023-11-21 正大制药（青岛）有限公司 一种氟骨化醇22,23-双键杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
JPS57149224A (en) * 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
EP0115314B1 (de) * 1983-01-28 1988-06-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Cholecalciferolderivaten
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters

Also Published As

Publication number Publication date
PH21540A (en) 1987-11-16
FI854492A0 (fi) 1985-11-14
KR860004073A (ko) 1986-06-16
CA1286693C (en) 1991-07-23
FI84599B (fi) 1991-09-13
PT81502B (pt) 1988-03-03
ATE48412T1 (de) 1989-12-15
FI854492L (fi) 1986-05-17
IL77052A (en) 1990-02-09
KR930007993B1 (ko) 1993-08-25
FI84599C (fi) 1991-12-27
IE852875L (en) 1986-05-16
US4613594A (en) 1986-09-23
ZA858151B (en) 1986-06-25
JPS61122237A (ja) 1986-06-10
EP0182298B1 (de) 1989-12-06
HUT39138A (en) 1986-08-28
IE58851B1 (en) 1993-11-17
DK524585A (da) 1986-05-17
IL77052A0 (en) 1986-04-29
HU194162B (en) 1988-01-28
NO162906B (no) 1989-11-27
MC1709A1 (fr) 1986-09-22
AR242767A1 (es) 1993-05-31
NZ214175A (en) 1989-04-26
PT81502A (en) 1985-12-01
EP0182298A1 (de) 1986-05-28
DK159652B (da) 1990-11-12
JPH051770B2 (es) 1993-01-11
DK524585D0 (da) 1985-11-13
AU5089885A (en) 1986-05-29
NO854576L (no) 1986-05-20
DE3574587D1 (de) 1990-01-11
ES548910A0 (es) 1987-12-16
NO162906C (no) 1990-03-07
DK159652C (da) 1991-04-08
AU588012B2 (en) 1989-09-07

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