ES8707961A1 - Un procedimiento para preparar nuevos compuestos de 14-oxa-1, 11-diazatetraciclo (7.4.1.0-2,7.o-10,12)tetradeca-2,4,6-trieno. - Google Patents
Un procedimiento para preparar nuevos compuestos de 14-oxa-1, 11-diazatetraciclo (7.4.1.0-2,7.o-10,12)tetradeca-2,4,6-trieno.Info
- Publication number
- ES8707961A1 ES8707961A1 ES552029A ES552029A ES8707961A1 ES 8707961 A1 ES8707961 A1 ES 8707961A1 ES 552029 A ES552029 A ES 552029A ES 552029 A ES552029 A ES 552029A ES 8707961 A1 ES8707961 A1 ES 8707961A1
- Authority
- ES
- Spain
- Prior art keywords
- protected
- hydroxymethyl
- hydroxy
- pharmaceutical composition
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- -1 arylaminomethyl Chemical group 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 14-OXA-1,11-DIAZATETRACICLO7.4.1.02,7.010,12 TETRADECA-2,4,6-TRIENO, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) O UNA DE SUS SALES, CON UN AGENTE ACILANTE CONVENCIONAL, CAPAZ DE INTRODUCIR UN GRUPO ACILO EN EL GRUPO IMINO, TAL COMO ACIDO CARBOXILICO, ACIDO CARBONICO, ACIDO SULFONICO Y SUS DERIVADOS REACTIVOS. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN DISOLVENTE CONVENCIONAL QUE NO INFLUYA ADVERSAMENTE SOBRE LA REACCION, TAL COMO AGUA, ALCOHOL, ACETONA, PIRIDINA Y SIMILARES. DE APLICACION EN LA PREPARACION DE MEDICAMENTOS UTILIZADOS EN EL TRATAMIENTO DE TUMORES, ENFERMEDADES INFECCIOSAS Y ANALOGOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848416141A GB8416141D0 (en) | 1984-06-25 | 1984-06-25 | Fr-900482 substance |
| GB858510378A GB8510378D0 (en) | 1985-04-24 | 1985-04-24 | Tetracyclo compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES552029A0 ES552029A0 (es) | 1987-09-01 |
| ES8707961A1 true ES8707961A1 (es) | 1987-09-01 |
Family
ID=26287918
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544482A Expired ES8703477A1 (es) | 1984-06-25 | 1985-06-24 | Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482. |
| ES552029A Expired ES8707961A1 (es) | 1984-06-25 | 1986-02-14 | Un procedimiento para preparar nuevos compuestos de 14-oxa-1, 11-diazatetraciclo (7.4.1.0-2,7.o-10,12)tetradeca-2,4,6-trieno. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544482A Expired ES8703477A1 (es) | 1984-06-25 | 1985-06-24 | Un procedimiento para preparar un nuevo compuesto tetraciclico denominado fr-900482. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US4645765A (es) |
| EP (1) | EP0166389B1 (es) |
| JP (3) | JPH078872B2 (es) |
| KR (1) | KR920009527B1 (es) |
| AU (1) | AU584097B2 (es) |
| CA (1) | CA1248897A (es) |
| DE (1) | DE3577850D1 (es) |
| DK (1) | DK170892B1 (es) |
| ES (2) | ES8703477A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK733888A (da) * | 1988-01-12 | 1989-07-13 | Fujisawa Pharmaceutical Co | Stabiliseringsmiddel |
| US4973693A (en) * | 1989-09-01 | 1990-11-27 | Shunsuke Goto | Novel pentacyclic compound and stereoselective synthesis thereof |
| EP0943689A4 (en) | 1996-10-29 | 2000-12-20 | Fujisawa Pharmaceutical Co | METHOD FOR PRODUCING FR900482 AND ANALOG CONNECTIONS |
| JP2003171280A (ja) * | 1999-06-07 | 2003-06-17 | Fujisawa Pharmaceut Co Ltd | 抗腫瘍効果増強剤 |
| WO2001097812A1 (fr) * | 2000-06-20 | 2001-12-27 | Fujisawa Pharmaceutical Co., Ltd. | Preparations pharmaceutiques contenant des composes tetracycliques |
| KR100768476B1 (ko) | 2005-11-24 | 2007-10-18 | 한국해양연구원 | 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물 |
| EP3040338B1 (en) * | 2013-08-29 | 2017-10-11 | Seed Research Institute Co., Ltd. | Novel microbial product having antifungal activity |
| CN111793015B (zh) * | 2020-07-14 | 2021-08-27 | 遵义医科大学 | 一种含氮三元环化合物Strepmycin A及其分离方法和抗菌应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB974168A (en) * | 1961-06-26 | 1964-11-04 | Ici Ltd | Manufacture of 2-ª-methoxyethylpyridine |
| US4313935A (en) * | 1979-03-05 | 1982-02-02 | Fujisawa Pharmaceutical Co., Ltd. | Antibiotic FR-900129 substance, a process for the preparation thereof and pharmaceutical compositions containing the same |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
-
1985
- 1985-06-11 US US06/743,616 patent/US4645765A/en not_active Expired - Lifetime
- 1985-06-17 AU AU43728/85A patent/AU584097B2/en not_active Ceased
- 1985-06-19 CA CA000484513A patent/CA1248897A/en not_active Expired
- 1985-06-21 EP EP85107681A patent/EP0166389B1/en not_active Expired - Lifetime
- 1985-06-21 DE DE8585107681T patent/DE3577850D1/de not_active Expired - Fee Related
- 1985-06-24 ES ES544482A patent/ES8703477A1/es not_active Expired
- 1985-06-24 KR KR1019850004482A patent/KR920009527B1/ko not_active Expired
- 1985-06-24 DK DK285585A patent/DK170892B1/da not_active IP Right Cessation
- 1985-06-25 JP JP63-325492A patent/JPH078872B2/ja not_active Expired - Lifetime
-
1986
- 1986-02-14 ES ES552029A patent/ES8707961A1/es not_active Expired
- 1986-09-30 US US06/913,478 patent/US4743555A/en not_active Expired - Lifetime
-
1988
- 1988-12-22 JP JP63325492A patent/JPH01199975A/ja active Pending
-
1994
- 1994-06-03 JP JP6122707A patent/JPH07102128B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4743555A (en) | 1988-05-10 |
| JPH01199975A (ja) | 1989-08-11 |
| ES552029A0 (es) | 1987-09-01 |
| JPH078872B2 (ja) | 1995-02-01 |
| DK285585A (da) | 1985-12-26 |
| US4645765A (en) | 1987-02-24 |
| KR860000385A (ko) | 1986-01-28 |
| AU4372885A (en) | 1986-01-02 |
| JPH078872B1 (es) | 1995-02-01 |
| JPH07102128B2 (ja) | 1995-11-08 |
| CA1248897A (en) | 1989-01-17 |
| DK170892B1 (da) | 1996-03-04 |
| DE3577850D1 (de) | 1990-06-28 |
| EP0166389A1 (en) | 1986-01-02 |
| ES8703477A1 (es) | 1987-02-16 |
| DK285585D0 (da) | 1985-06-24 |
| ES544482A0 (es) | 1987-02-16 |
| EP0166389B1 (en) | 1990-05-23 |
| AU584097B2 (en) | 1989-05-18 |
| JPH0767623A (ja) | 1995-03-14 |
| KR920009527B1 (ko) | 1992-10-17 |
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