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ES8704491A1 - Procedimiento para la obtencion de nuevas piridopirimidinas - Google Patents

Procedimiento para la obtencion de nuevas piridopirimidinas

Info

Publication number
ES8704491A1
ES8704491A1 ES551013A ES551013A ES8704491A1 ES 8704491 A1 ES8704491 A1 ES 8704491A1 ES 551013 A ES551013 A ES 551013A ES 551013 A ES551013 A ES 551013A ES 8704491 A1 ES8704491 A1 ES 8704491A1
Authority
ES
Spain
Prior art keywords
pyridopyrimidines
medicaments
preparation
well
different processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551013A
Other languages
English (en)
Other versions
ES551013A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES551013A0 publication Critical patent/ES551013A0/es
Publication of ES8704491A1 publication Critical patent/ES8704491A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDOPIRIMIDINAS, DE FORMULA (I). COMPRENDE LA REACCION DE UN ILIDEN-B-DICARBONILCOMPUESTO, DE FORMULA (II), CON UNA 6-AMINOPIRIDINA DE FORMULA (III), EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 150JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R1-R7 PUEDEN SER VARIOS TIPOS DE RADICALES. TAMBIEN SE PUEDE OBTENER EL COMPUESTO DE FORMULA (I) POR REACCION ADECUADA DE OTROS REACTIVOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO VASODILATADOR RENAL Y DIURETICO.
ES551013A 1985-01-19 1986-01-17 Procedimiento para la obtencion de nuevas piridopirimidinas Expired ES8704491A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853501696 DE3501696A1 (de) 1985-01-19 1985-01-19 Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES551013A0 ES551013A0 (es) 1987-04-01
ES8704491A1 true ES8704491A1 (es) 1987-04-01

Family

ID=6260235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551013A Expired ES8704491A1 (es) 1985-01-19 1986-01-17 Procedimiento para la obtencion de nuevas piridopirimidinas

Country Status (18)

Country Link
US (1) US4621082A (es)
EP (1) EP0189045B1 (es)
JP (1) JPS61167688A (es)
CN (1) CN1010947B (es)
AT (1) ATE50407T1 (es)
AU (1) AU578783B2 (es)
CA (1) CA1276636C (es)
DE (2) DE3501696A1 (es)
DK (1) DK23386A (es)
ES (1) ES8704491A1 (es)
FI (1) FI81574C (es)
GR (1) GR860117B (es)
HU (1) HU195812B (es)
NO (1) NO164353C (es)
NZ (1) NZ214842A (es)
PH (1) PH22610A (es)
PT (1) PT81860B (es)
ZA (1) ZA86363B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598093B2 (en) * 1987-02-07 1990-06-14 Wellcome Foundation Limited, The Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof
DE69132944T2 (de) * 1990-11-30 2002-11-21 Otsuka Pharmaceutical Co., Ltd. Azolederivate als Inhibitor von Superoxide-Radikalen
JPH04260503A (ja) * 1991-02-13 1992-09-16 Sekisui Jushi Co Ltd ピッキングシステム
JP3013905B2 (ja) * 1991-06-28 2000-02-28 花王株式会社 自動倉庫の入出庫方法
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5405848A (en) * 1993-12-22 1995-04-11 Ortho Pharmaceutical Corporation Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors
US6756367B2 (en) 1998-02-03 2004-06-29 Novartis Ag Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
MXPA05006123A (es) * 2002-12-13 2005-09-30 Neurogen Corp Analogos de quinazolin-4-ilamina 2-sustituida como moduladores de receptores de capsaicina.
US20070082920A1 (en) * 2005-10-06 2007-04-12 Yongsheng Song NAD+-dependent DNA ligase inhibitors
DE102006026583A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102006026585A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
CN107405350A (zh) * 2016-02-04 2017-11-28 江苏恒瑞医药股份有限公司 一种含有吡啶并嘧啶类衍生物或其可药用盐的药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021332A (en) * 1954-01-04 1962-02-13 Burroughs Wellcome Co Pyrido (2, 3-d) pyrimidine compounds and method of making
GB1129084A (en) * 1965-02-18 1968-10-02 Wellcome Found Novel pyrido[2,3-d]pyrimidines
DE3438350A1 (de) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-oxo-pyrido (2,3-d) pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung
DE3438351A1 (de) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
ES551013A0 (es) 1987-04-01
PT81860B (pt) 1988-05-27
DK23386A (da) 1986-07-20
US4621082A (en) 1986-11-04
AU5219386A (en) 1986-07-24
FI81574B (fi) 1990-07-31
EP0189045B1 (de) 1990-02-14
EP0189045A2 (de) 1986-07-30
HUT40127A (en) 1986-11-28
PH22610A (en) 1988-10-17
CN86100279A (zh) 1986-11-19
DE3501696A1 (de) 1986-07-24
NZ214842A (en) 1988-07-28
FI81574C (fi) 1990-11-12
ATE50407T1 (de) 1990-02-15
FI860197A0 (fi) 1986-01-16
NO855342L (no) 1986-07-21
DK23386D0 (da) 1986-01-17
GR860117B (en) 1986-05-16
DE3669041D1 (de) 1990-03-22
PT81860A (en) 1986-02-01
ZA86363B (en) 1986-09-24
FI860197A7 (fi) 1986-07-20
HU195812B (en) 1988-07-28
CN1010947B (zh) 1990-12-26
JPS61167688A (ja) 1986-07-29
EP0189045A3 (en) 1988-10-05
NO164353C (no) 1990-09-26
CA1276636C (en) 1990-11-20
NO164353B (no) 1990-06-18
AU578783B2 (en) 1988-11-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203