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ES8704468A1 - Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos - Google Patents

Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos

Info

Publication number
ES8704468A1
ES8704468A1 ES554373A ES554373A ES8704468A1 ES 8704468 A1 ES8704468 A1 ES 8704468A1 ES 554373 A ES554373 A ES 554373A ES 554373 A ES554373 A ES 554373A ES 8704468 A1 ES8704468 A1 ES 8704468A1
Authority
ES
Spain
Prior art keywords
formula
procedure
carbamates
triazole
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554373A
Other languages
English (en)
Other versions
ES554373A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8704468A1 publication Critical patent/ES8704468A1/es
Publication of ES554373A0 publication Critical patent/ES554373A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1,2,4-TRIAZOLOCARBAMATOS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN ISOCIANATO DE FORMULA OFCFN-R4, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE R1-R4 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE C50JC Y LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO INHIBIDOR DE LA ACETILCOLINESTERASA CENTRAL.
ES554373A 1984-10-27 1986-04-25 Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos Expired ES8704468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843439450 DE3439450A1 (de) 1984-10-27 1984-10-27 1,2,4-triazolo-carbamate und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
ES8704468A1 true ES8704468A1 (es) 1987-04-01
ES554373A0 ES554373A0 (es) 1987-04-01

Family

ID=6248953

Family Applications (2)

Application Number Title Priority Date Filing Date
ES548206A Expired ES8701738A1 (es) 1984-10-27 1985-10-25 Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos
ES554373A Expired ES8704468A1 (es) 1984-10-27 1986-04-25 Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES548206A Expired ES8701738A1 (es) 1984-10-27 1985-10-25 Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos

Country Status (22)

Country Link
US (1) US4732900A (es)
EP (1) EP0180115A3 (es)
JP (1) JPS61103876A (es)
KR (1) KR860003240A (es)
AU (1) AU576393B2 (es)
CA (1) CA1244030A (es)
CS (2) CS255877B2 (es)
DD (1) DD236928A5 (es)
DE (1) DE3439450A1 (es)
DK (1) DK491385A (es)
ES (2) ES8701738A1 (es)
FI (1) FI854178L (es)
GR (1) GR852581B (es)
HU (1) HU193351B (es)
IL (1) IL76823A0 (es)
NO (1) NO854276L (es)
NZ (1) NZ213969A (es)
PH (1) PH22446A (es)
PL (2) PL255940A1 (es)
PT (1) PT81370B (es)
SU (2) SU1436873A3 (es)
ZA (1) ZA858195B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2784921B2 (ja) * 1988-03-23 1998-08-13 武田薬品工業株式会社 カルバメート化合物
US5100906A (en) * 1990-04-19 1992-03-31 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
US5331002A (en) * 1990-04-19 1994-07-19 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
DE4234801A1 (de) * 1992-10-15 1994-04-21 Bayer Ag Sulfonylaminocarbonyltriazolinone
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
US5728834A (en) * 1996-11-14 1998-03-17 Wyckoff Chemical Company, Inc. Process for preparation of 4-aryl-1,2,4-triazol-3-ones
BRPI0509172A (pt) * 2004-03-26 2007-08-28 Amphora Discovery Corp pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
CA2594488C (en) * 2005-01-10 2015-04-28 University Of Connecticut Novel heteropyrrole analogs acting on cannabinoid receptors
US8853205B2 (en) 2005-01-10 2014-10-07 University Of Connecticut Heteropyrrole analogs acting on cannabinoid receptors
US10053444B2 (en) 2009-02-19 2018-08-21 University Of Connecticut Cannabinergic nitrate esters and related analogs
CA3125847A1 (en) 2020-07-27 2022-01-27 Makscientific, Llc Process for making biologically active compounds and intermediates thereof
US12054480B2 (en) 2020-07-31 2024-08-06 Makscientific, Llc Compounds for treating cannabinoid toxicity and acute cannabinoid overdose
CN115991698B (zh) * 2022-11-03 2024-03-29 广东中科药物研究有限公司 一种杂环化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB681376A (en) * 1949-11-23 1952-10-22 Geigy Ag J R Manufacture of heterocyclic carbamic acid derivatives and their use as agents for combating pests
NL7112373A (es) * 1970-09-25 1972-03-28
US4209515A (en) * 1974-06-14 1980-06-24 Ciba-Geigy Corporation Triazole derivatives
US4160839A (en) * 1976-03-01 1979-07-10 Gulf Oil Corporation Carbamyltriazole insecticides
JPS59199681A (ja) * 1983-04-26 1984-11-12 Ube Ind Ltd １，２，４−トリアゾ−ル−３−カルボン酸アミド類の製造法
FI850994A7 (fi) * 1984-03-16 1985-09-17 Ciba Geigy Ag Menetelmä uusien 1,2,4 -triatsasykloalkadieenijohdannaisten valmistamiseksi.
US4610717A (en) * 1985-11-26 1986-09-09 Shell Oil Company Certain 5-(R-oxy)-1-phenyl or (3-(trifluoromethyl)phenyl)triazoles, useful for controlling undesired plant growth

Also Published As

Publication number Publication date
CS255897B2 (en) 1988-03-15
ES548206A0 (es) 1986-12-01
PT81370A (de) 1985-11-01
PT81370B (de) 1987-08-20
AU4909485A (en) 1986-05-01
ZA858195B (en) 1987-06-24
DD236928A5 (de) 1986-06-25
HUT40091A (en) 1986-11-28
DK491385A (da) 1986-04-28
NO854276L (no) 1986-04-28
NZ213969A (en) 1987-11-27
EP0180115A3 (de) 1987-01-21
GR852581B (es) 1986-02-26
US4732900A (en) 1988-03-22
SU1436873A3 (ru) 1988-11-07
JPS61103876A (ja) 1986-05-22
PL264492A1 (en) 1987-11-30
DK491385D0 (da) 1985-10-25
KR860003240A (ko) 1986-05-21
ES8701738A1 (es) 1986-12-01
ES554373A0 (es) 1987-04-01
CS255877B2 (en) 1988-03-15
PL255940A1 (en) 1987-07-13
FI854178A7 (fi) 1986-04-28
CA1244030A (en) 1988-11-01
EP0180115A2 (de) 1986-05-07
DE3439450A1 (de) 1986-05-07
PH22446A (en) 1988-09-12
FI854178A0 (fi) 1985-10-25
HU193351B (en) 1987-09-28
IL76823A0 (en) 1986-02-28
AU576393B2 (en) 1988-08-25
FI854178L (fi) 1986-04-28
SU1429934A3 (ru) 1988-10-07

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