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ES8104245A1 - Procedimiento para la preparacion de derivados de bencimida-zol - Google Patents

Procedimiento para la preparacion de derivados de bencimida-zol

Info

Publication number
ES8104245A1
ES8104245A1 ES491143A ES491143A ES8104245A1 ES 8104245 A1 ES8104245 A1 ES 8104245A1 ES 491143 A ES491143 A ES 491143A ES 491143 A ES491143 A ES 491143A ES 8104245 A1 ES8104245 A1 ES 8104245A1
Authority
ES
Spain
Prior art keywords
derivatives
radicals
formula
compositions containing
different types
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491143A
Other languages
English (en)
Other versions
ES491143A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Publication of ES8104245A1 publication Critical patent/ES8104245A1/es
Publication of ES491143A0 publication Critical patent/ES491143A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENCIMIDAZOL, DE FORMULA GENERAL (I), DONDE R1 PUEDE SER DISTINTOS TIPOS DE RADICALES; R2 Y R3 PUEDEN SER HIDROGENO O DISTINTOS TIPOS DE RADICALES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONE B Y Q REPRESENTAN DISTINTOS RADICALES, CON UN COMPUESTO DE FORMULA R1Z'', DONDE Z'' PUEDE SER DISTINTOS TIPOS DE RADICALES. ESTOS PRODUCTOS SE APLICAN PARA LA PROFILAXIS Y TRATAMIENTO DE LA HIPERTENSION Y AFECCIONES CARDIOVASCULARES. *FORMULA*
ES491143A 1979-05-04 1980-05-02 Procedimiento para la preparacion de derivados de bencimida-zol Granted ES491143A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU81225 1979-05-04

Publications (2)

Publication Number Publication Date
ES8104245A1 true ES8104245A1 (es) 1981-04-16
ES491143A0 ES491143A0 (es) 1981-04-16

Family

ID=19729148

Family Applications (2)

Application Number Title Priority Date Filing Date
ES491143A Granted ES491143A0 (es) 1979-05-04 1980-05-02 Procedimiento para la preparacion de derivados de bencimida-zol
ES491142A Granted ES491142A0 (es) 1979-05-04 1980-05-02 Procedimiento para la preparacion de derivados de fenileti- lamina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES491142A Granted ES491142A0 (es) 1979-05-04 1980-05-02 Procedimiento para la preparacion de derivados de fenileti- lamina

Country Status (22)

Country Link
US (1) US4338330A (es)
JP (2) JPS565465A (es)
AT (2) AT376418B (es)
AU (2) AU542596B2 (es)
BE (2) BE883069A (es)
CA (1) CA1146563A (es)
CH (2) CH644599A5 (es)
DE (2) DE3016828A1 (es)
DK (2) DK187880A (es)
ES (2) ES491143A0 (es)
FI (2) FI801428A7 (es)
FR (2) FR2455587A1 (es)
GB (2) GB2055091B (es)
GR (2) GR68536B (es)
IE (1) IE50218B1 (es)
IL (2) IL59974A0 (es)
IT (2) IT1150018B (es)
NL (2) NL8002567A (es)
NO (2) NO801286L (es)
PT (2) PT71174A (es)
SE (2) SE8003277L (es)
ZA (2) ZA802695B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1156661A (en) * 1980-02-25 1983-11-08 Hoffmann-La Roche Limited Phenoxy-aminopropanol derivatives
JPS582343A (ja) * 1981-06-30 1983-01-07 Osaka Soda Co Ltd 耐窒素酸化物性に優れた加硫性ゴム組成物
GB8310556D0 (en) * 1983-04-19 1983-05-25 Beecham Group Plc Compounds
US4550119A (en) * 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
US5104892A (en) * 1989-12-11 1992-04-14 American Home Products Corporation Substituted benzimidazole derivatives possessing Class III antiarrhythmic activity
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
CA2479338A1 (en) * 2002-03-20 2003-10-02 Metabolex, Inc. Substituted phenylacetic acids
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
EP1749000A4 (en) * 2004-05-25 2009-12-30 Metabolex Inc BICYCLIC SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND METHOD FOR THE PRODUCTION THEREOF
AU2005247473A1 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Substituted triazoles as modulators of PPAR and methods of their preparation
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
EP2727911B1 (en) * 2012-10-31 2016-12-21 Medizinische Hochschule Hannover Novel means and methods for treating malaria and other parasitic disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157556A (en) * 1966-06-09 1969-07-09 Egyt Gyogyszervegyeszeti Gyar Novel Benzazole Derivatives and the Preparation thereof
FR1570892A (es) * 1968-06-18 1969-06-13
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
JPS5231858B1 (es) * 1969-12-17 1977-08-17
CH624395A5 (es) 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
DE2640730C2 (de) * 1976-09-10 1983-08-25 Hoechst Ag, 6230 Frankfurt Benzoxazolyloxy- und Benzothiazolyloxy-phenoxy-Verbindungen und diese enthaltende herbizide Mittel
DE2644833A1 (de) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung
DE2737630A1 (de) 1977-08-20 1979-03-01 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2801953A1 (de) 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolinon-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE2801980A1 (de) 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (de) 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2905876A1 (de) 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue piperidinopropylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2905877A1 (de) 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
NO150916C (no) 1985-01-16
FR2455572A1 (fr) 1980-11-28
IT1159060B (it) 1987-02-25
IL59973A (en) 1985-03-31
IL59974A0 (en) 1980-07-31
CA1146563A (en) 1983-05-17
ZA802694B (en) 1981-08-26
GB2055091B (en) 1983-11-09
IT8021780A1 (it) 1981-11-02
JPS565465A (en) 1981-01-20
JPS5663946A (en) 1981-05-30
PT71174A (fr) 1980-05-01
CH644599A5 (fr) 1984-08-15
GB2055091A (en) 1981-02-25
ZA802695B (en) 1981-08-26
AU542596B2 (en) 1985-02-28
GR68536B (es) 1982-01-18
FI801428A7 (fi) 1980-11-05
AT376210B (de) 1984-10-25
DK187980A (da) 1980-11-05
AU5809680A (en) 1980-11-06
IT1150018B (it) 1986-12-10
IE50218B1 (en) 1986-03-05
FR2455587B1 (es) 1983-06-24
IT8021780A0 (it) 1980-05-02
SE8003278L (sv) 1980-11-05
NO150916B (no) 1984-10-01
IL59973A0 (en) 1980-07-31
BE883069A (fr) 1980-08-18
NO801286L (no) 1980-11-05
DK187880A (da) 1980-11-05
PT71175A (fr) 1980-05-01
IE800918L (en) 1980-11-04
DE3016828A1 (de) 1980-11-13
GR68535B (es) 1982-01-18
JPS6033424B2 (ja) 1985-08-02
SE8003277L (sv) 1980-11-05
AU537573B2 (en) 1984-07-05
ES8103729A1 (es) 1981-03-16
GB2055360B (en) 1983-07-06
NL8002567A (nl) 1980-11-06
ATA238680A (de) 1984-04-15
FI801429A7 (fi) 1980-11-05
IT8021779A0 (it) 1980-05-02
ES491142A0 (es) 1981-03-16
NO801285L (no) 1980-11-05
AU5809580A (en) 1980-11-06
IT8021779A1 (it) 1981-11-02
FR2455587A1 (fr) 1980-11-28
GB2055360A (en) 1981-03-04
ES491143A0 (es) 1981-04-16
US4338330A (en) 1982-07-06
BE883068A (fr) 1980-08-18
AT376418B (de) 1984-11-26
FR2455572B1 (fr) 1986-07-25
ATA238780A (de) 1984-03-15
CH645090A5 (fr) 1984-09-14
NL8002568A (nl) 1980-11-06
DE3016827A1 (de) 1980-11-20

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