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ES8606289A1 - Un procedimiento para la preparacion de piridazinaminas. - Google Patents

Un procedimiento para la preparacion de piridazinaminas.

Info

Publication number
ES8606289A1
ES8606289A1 ES541521A ES541521A ES8606289A1 ES 8606289 A1 ES8606289 A1 ES 8606289A1 ES 541521 A ES541521 A ES 541521A ES 541521 A ES541521 A ES 541521A ES 8606289 A1 ES8606289 A1 ES 8606289A1
Authority
ES
Spain
Prior art keywords
pyridazinamines
virally active
virally
active pyridazinamines
warm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541521A
Other languages
English (en)
Other versions
ES541521A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES8606289A1 publication Critical patent/ES8606289A1/es
Publication of ES541521A0 publication Critical patent/ES541521A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRIDAZINAMINAS. CONSISTE EN N-ALQUILAR A UNA AMINA D.F. (II) CON UNA PIRIDAZINA D.F. (III), EN BENCENO O METILBENCENO, EN PRESENCIA DE UNA BASE COMO HIDRURO SODICO O N,N-DIETILETANAMINA, P.O. UN C.D.F. (I) Y UNA SAL DE EDICION FARMACEUTICAMENTE ACEPTABLE, UNA FORMA ESTEREOQUIMICA ISOMERICA Y/O UNA FORMA TAUTOMERICA. SIENDO: R1, H, HAL, 1H-IMIDAZOL-1-ILO Y OTROS; R2 Y R3 INDEPENDIENTES ENTRE SI H O ALQUILO INFERIOR Y JUNTOS UN RADICAL BIVALENTE -CHFCHCCHFCH-; A2 -CHFNCCHFCH-, UN RADICAL DE FORMULA (IV) O (V); R4-C TIAZOLILO, PIRIMIDILO, ARIL-ALQUILO INFERIOR Y OTROS; R5 Y R6 H, ALQUILO INFERIOR Y OTROS; R5 Y R6 H, ALQUILO INFERIOR, ARILO Y OTROS; D.F. DE FORMULA; C.D.F. COMPUESTO D.F. Y M Y N UN NUMERO ENTERO ENTRE 1 Y 4 Y P.O PARA OBTENER. SE UTILIZA PARA EL TRATAMIENTO VIRICO EN ANIMALES DE SANGRE CALIENTE.
ES541521A 1984-03-26 1985-03-22 Un procedimiento para la preparacion de piridazinaminas. Expired ES8606289A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59344484A 1984-03-26 1984-03-26
US06/702,772 US5001125A (en) 1984-03-26 1985-02-15 Anti-virally active pyridazinamines

Publications (2)

Publication Number Publication Date
ES8606289A1 true ES8606289A1 (es) 1986-04-16
ES541521A0 ES541521A0 (es) 1986-04-16

Family

ID=27081705

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541521A Expired ES8606289A1 (es) 1984-03-26 1985-03-22 Un procedimiento para la preparacion de piridazinaminas.

Country Status (22)

Country Link
US (3) US5001125A (es)
EP (1) EP0156433B1 (es)
KR (1) KR870001158B1 (es)
AT (1) ATE61050T1 (es)
AU (1) AU576563B2 (es)
BG (1) BG43690A3 (es)
CA (1) CA1238321A (es)
CZ (1) CZ277730B6 (es)
DE (1) DE3581819D1 (es)
DK (1) DK166277C (es)
ES (1) ES8606289A1 (es)
FI (1) FI85373C (es)
GR (1) GR850714B (es)
HU (1) HU198010B (es)
IL (1) IL74707A (es)
NO (1) NO161257C (es)
NZ (1) NZ211494A (es)
PH (1) PH22495A (es)
PT (1) PT80157B (es)
RO (1) RO91197B (es)
SU (1) SU1384198A3 (es)
ZW (1) ZW5485A1 (es)

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HUT37614A (en) 1986-01-23
NO161257C (no) 1989-07-26
DK166277B (da) 1993-03-29
GR850714B (es) 1985-06-14
ZW5485A1 (en) 1986-10-22
AU576563B2 (en) 1988-09-01
HU198010B (en) 1989-07-28
DK134185D0 (da) 1985-03-25
DK166277C (da) 1993-08-30
FI85373C (fi) 1992-04-10
US5001125A (en) 1991-03-19
FI85373B (fi) 1991-12-31
AU4034885A (en) 1985-10-03
CS195285A3 (en) 1992-11-18
PT80157A (en) 1985-04-01
BG43690A3 (en) 1988-07-15
DK134185A (da) 1985-09-27
FI851177L (fi) 1985-09-27
EP0156433B1 (en) 1991-02-27
IL74707A (en) 1988-05-31
CZ277730B6 (en) 1993-04-14
DE3581819D1 (de) 1991-04-04
SU1384198A3 (ru) 1988-03-23
FI851177A0 (fi) 1985-03-25
EP0156433A2 (en) 1985-10-02
PT80157B (en) 1987-03-20
PH22495A (en) 1988-09-12
RO91197A (ro) 1987-06-30
CA1238321A (en) 1988-06-21
US5292738A (en) 1994-03-08
RO91197B (ro) 1987-07-01
NO161257B (no) 1989-04-17
KR850006401A (ko) 1985-10-05
NZ211494A (en) 1988-05-30
NO851167L (no) 1985-09-27
US5157035A (en) 1992-10-20
ATE61050T1 (de) 1991-03-15
IL74707A0 (en) 1985-06-30
EP0156433A3 (en) 1986-07-23
KR870001158B1 (ko) 1987-06-13
ES541521A0 (es) 1986-04-16

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