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ES8604922A1 - Procedimiento para la preparacion de n-piridilindoles - Google Patents

Procedimiento para la preparacion de n-piridilindoles

Info

Publication number
ES8604922A1
ES8604922A1 ES545154A ES545154A ES8604922A1 ES 8604922 A1 ES8604922 A1 ES 8604922A1 ES 545154 A ES545154 A ES 545154A ES 545154 A ES545154 A ES 545154A ES 8604922 A1 ES8604922 A1 ES 8604922A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
formula
piridylindols
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545154A
Other languages
English (en)
Other versions
ES545154A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8604922A1 publication Critical patent/ES8604922A1/es
Publication of ES545154A0 publication Critical patent/ES545154A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE N-PIRIDILINDOLES. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER N-PIRIDILINDONES DE FORMULA (I) EN DONDE AR ES 3- O 4-PIRIDILO O 3- O 4-PIRIDILO SUSTITUIDO POR ALQUILO INFERIOR; LOS RADICALES R1 REPRESENTAN INDEPENDIENTEMENTE UNO DE OTRO, H, HALOGENO, TRIFLUORMETILO Y OTROS; P ES 1 O 2; R2 ES H O ALQUILO INFERIOR; UNO DE R3 Y R4 REPRESENTA H Y EL OTRO DE R3 Y R4 REPRESENTA EL GRUPO A-B EN DONDE A ES ALQUILENO DE C 1 A 12, ALQUINILENO Y OTROS, Y B REPRESENTA CARBOXI, CARBOXI ESTERIFICADO, CARBAMOILO, MONO O DI-ALQUIL(INFERIOR)CARBAMOILO Y OTROS.
ES545154A 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles Expired ES8604922A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/495,370 US4536505A (en) 1983-05-17 1983-05-17 Certain N-(pyridyl) indoles

Publications (2)

Publication Number Publication Date
ES8604922A1 true ES8604922A1 (es) 1986-02-16
ES545154A0 ES545154A0 (es) 1986-02-16

Family

ID=23968377

Family Applications (5)

Application Number Title Priority Date Filing Date
ES532572A Granted ES532572A0 (es) 1983-05-17 1984-05-17 Procedimiento para la preparacion de n-piridilindoles
ES545153A Expired ES8604197A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545152A Expired ES8604196A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545154A Expired ES8604922A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545151A Expired ES8604195A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES532572A Granted ES532572A0 (es) 1983-05-17 1984-05-17 Procedimiento para la preparacion de n-piridilindoles
ES545153A Expired ES8604197A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545152A Expired ES8604196A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES545151A Expired ES8604195A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Country Status (15)

Country Link
US (1) US4536505A (es)
EP (1) EP0126401A1 (es)
JP (1) JPS59212489A (es)
KR (1) KR840009302A (es)
AU (1) AU2809484A (es)
DD (1) DD224588A5 (es)
DK (1) DK242484A (es)
ES (5) ES532572A0 (es)
FI (1) FI841925A7 (es)
GR (1) GR79934B (es)
HU (1) HUT34182A (es)
IL (1) IL71832A0 (es)
NO (1) NO841958L (es)
PT (1) PT78582A (es)
ZA (1) ZA843677B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
US4758586A (en) * 1985-02-01 1988-07-19 Usv Pharmaceutical Corp. Indolyl compounds and hyposensitivity use thereof
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
US5550118A (en) * 1994-01-31 1996-08-27 Eli Lilly And Company Polyhydronorharman synthase inhibitors
US5977125A (en) * 1994-10-31 1999-11-02 Eisai Co., Ltd. Mono-or polyenic carboxylic acid derivatives
GB2295151B (en) * 1994-11-18 1998-12-09 Nmc Polymerization of substituted heterocyclic monomers
EP1056452B1 (en) * 1998-02-23 2006-07-19 South Alabama Medical Science Foundation Indole-3-propionic acids, salts and esters thereof used as medicaments
WO2003027085A2 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
EP1943228A2 (en) * 2005-10-11 2008-07-16 Intermune, Inc. Inhibitors of viral replication
KR100807718B1 (ko) * 2006-10-17 2008-02-28 한국생명공학연구원 인돌 유도체를 유효성분으로 함유하는 대사성 질환 예방 및치료용 약학적 조성물
CN101687789A (zh) * 2007-02-12 2010-03-31 因特蒙公司 C型肝炎病毒复制的新颖抑制剂
WO2008120818A1 (ja) * 2007-03-29 2008-10-09 Asubio Pharma Co., Ltd. ｃＰＬＡ２阻害活性を有するインドール誘導体およびその用途並びに製造方法
USD1099827S1 (en) * 2023-06-05 2025-10-28 Apple Inc. Cable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449348A (en) * 1968-01-08 1969-06-10 Merck & Co Inc Alpha-halomethyl-1-pyridine or quinoline carbonyl-3-indolylacetic acids
AT299938B (de) * 1971-02-03 1972-07-10 Italiana Sint Spa Verfahren zur Herstellung des neuen Natriumsalzes der (1-Nicotinoyl-2-methyl-5-methoxy-3-indolyl)-essigsäure, gegebenenfalls im Gemisch mit der freien Säure
FR2171936B1 (es) * 1972-02-16 1975-04-25 Clin Midy
FR2171937A1 (en) * 1972-02-16 1973-09-28 Clin Midy Aminoketo indoles - analgesics and antidepressants
AT323154B (de) * 1973-02-02 1975-06-25 Hurka Wilhelm Verfahren zur herstellung von neuen 5-methoxy-2-methylindol-3-essigsäurederivaten sowie von deren salzen
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
US4363912A (en) * 1980-12-15 1982-12-14 Pfizer Inc. Indole thromboxane synthetase inhibitors
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB2102795A (en) * 1981-07-31 1983-02-09 Pfizer Ltd Indole derivatives
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles

Also Published As

Publication number Publication date
KR840009302A (ko) 1984-12-26
ES545154A0 (es) 1986-02-16
ES545153A0 (es) 1986-01-16
ES8604196A1 (es) 1986-01-16
ES8602652A1 (es) 1985-12-01
US4536505A (en) 1985-08-20
PT78582A (en) 1984-06-01
FI841925A0 (fi) 1984-05-14
ZA843677B (en) 1985-02-27
ES8604197A1 (es) 1986-01-16
ES545151A0 (es) 1986-01-16
DD224588A5 (de) 1985-07-10
AU2809484A (en) 1984-11-22
GR79934B (es) 1984-10-31
ES532572A0 (es) 1985-12-01
IL71832A0 (en) 1984-09-30
EP0126401A1 (de) 1984-11-28
DK242484D0 (da) 1984-05-16
JPS59212489A (ja) 1984-12-01
FI841925A7 (fi) 1984-11-18
ES545152A0 (es) 1986-01-16
NO841958L (no) 1984-11-19
DK242484A (da) 1984-11-18
ES8604195A1 (es) 1986-01-16
HUT34182A (en) 1985-02-28

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