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ES8604093A1 - Un procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftil-propionicos - Google Patents

Un procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftil-propionicos

Info

Publication number
ES8604093A1
ES8604093A1 ES537876A ES537876A ES8604093A1 ES 8604093 A1 ES8604093 A1 ES 8604093A1 ES 537876 A ES537876 A ES 537876A ES 537876 A ES537876 A ES 537876A ES 8604093 A1 ES8604093 A1 ES 8604093A1
Authority
ES
Spain
Prior art keywords
alkyl
opt
halogen
substd
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537876A
Other languages
English (en)
Other versions
ES537876A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Chemicals Italiana SpA
Original Assignee
Alfa Chemicals Italiana SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11110920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8604093(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alfa Chemicals Italiana SpA filed Critical Alfa Chemicals Italiana SpA
Publication of ES8604093A1 publication Critical patent/ES8604093A1/es
Publication of ES537876A0 publication Critical patent/ES537876A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA RESOLUCION OPTICA DE MEZCLAS RACEMICAS DE ACIDOS ALFA-NAFTIL-PROPIONICOS, DE FORMULA GENERAL (I), EN LA QUE R1 ES UN RADICAL DE (C1-6) ALQUILO; Y R2 SIGNIFICA HIDROGENO, HALOGENO O MERCAPTO. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UN SUSTRATO SUSTANCIALMENTE RACEMICO DE FORMULA GENERAL (II) CON UNA SUSTANCIA DE FORMULA GENERAL: R4-NH2, EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE Y DE UNA CANTIDAD CATALITICA DE UN AGENTE ALCALINO FUERTE, PARA OBTENER UN PAR DE AMIDAS DIASTEREOISOMERICAS; SEGUNDA, SE RESUELVE DICHO PAR DE AMIDAS DIASTEREOISOMERICAS EN LAS AMIDAS DIASTEREOISOMERICAS SIMPLES; Y POR ULTIMO, SO SOMETE LA AMIDA DIASTEREOISOMERICA SIMPLE OBTENIDA A HIDROLISIS ACIDA, PARA RECUPERAR EL COMPUESTO DE FORMULA GENERAL (III).-
ES537876A 1983-11-23 1984-11-22 Un procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftil-propionicos Expired ES8604093A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8303632A IT1208109B (it) 1983-11-23 1983-11-23 Procedimento per la risoluzione ottica di acidi arilpropionici

Publications (2)

Publication Number Publication Date
ES8604093A1 true ES8604093A1 (es) 1986-01-16
ES537876A0 ES537876A0 (es) 1986-01-16

Family

ID=11110920

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537876A Expired ES8604093A1 (es) 1983-11-23 1984-11-22 Un procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftil-propionicos

Country Status (22)

Country Link
US (1) US4661628A (es)
EP (1) EP0143371B2 (es)
JP (1) JPH0610155B2 (es)
KR (1) KR900001006B1 (es)
AR (1) AR241700A1 (es)
AT (1) ATE32601T1 (es)
AU (1) AU569351B2 (es)
CA (1) CA1226296A (es)
DE (2) DE3469437D1 (es)
DK (1) DK166271C (es)
ES (1) ES8604093A1 (es)
FI (1) FI83073C (es)
GR (1) GR81019B (es)
HU (2) HU196582B (es)
IE (1) IE58430B1 (es)
IL (1) IL73416A (es)
IT (1) IT1208109B (es)
NO (1) NO160359C (es)
NZ (1) NZ210133A (es)
PT (1) PT79527B (es)
YU (1) YU42907B (es)
ZA (1) ZA848639B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196334B (it) * 1984-11-22 1988-11-16 Alfa Chem Ital Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici
US4912248A (en) * 1987-05-18 1990-03-27 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
AU611699B2 (en) * 1987-07-31 1991-06-20 American Home Products Corporation Naphthalene propionic acid derivatives
EP0338645B1 (en) * 1988-04-21 1996-05-22 Gist-Brocades N.V. Process for producing an optically active 2-arylpropionic acid
IT1271800B (it) * 1994-12-27 1997-06-09 Zambon Spa Processo di preparazione degli enantiomeri dell'acido 2- (2-fluoro- 4-bifenil) propionico
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
DE10257761A1 (de) 2002-12-10 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung optisch aktiver Dihydropyrone

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553257A (en) * 1966-09-16 1971-01-05 American Cyanamid Co Preparation of d-2-amino-1-butanol salts
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
ZA70809B (en) * 1969-03-24 1971-09-29 Syntex Corp Amine salts of 2-(6'-methoxy-2'-naphthyl)propionic acids and processes for the preparation thereof
US3651106A (en) * 1969-09-30 1972-03-21 Syntex Corp Preparation of 2-(6-methoxy-2-naphthyl)propionic acid -1-propanol and propanal and intermediates therefor
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
US3904683A (en) * 1972-08-10 1975-09-09 Syntex Corp Process for the resolution of d- and 1-2-(6-methoxy-2-naphthyl) propionic acid
US4246193A (en) * 1979-11-26 1981-01-20 Syntex Corporation Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
JPS5822139B2 (ja) * 1979-12-28 1983-05-06 日清製粉株式会社 ｄｌ−２−（６−メトキシ−２−ナフチル）−プロピオン酸の光学分割法
IT1154663B (it) * 1980-07-30 1987-01-21 Alfa Chimica Italiana Spa Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico
FI901487A0 (fi) * 1981-12-11 1990-03-26 Syntex Pharma Int Framstaellning av x-arylalkansyror.
FI831820A7 (fi) * 1982-05-27 1983-11-28 Syntex Pharmaceuticals Int Menetelmä D-2-(6-metoksi-2- naftyyli)propionihapon ja sen farmaseuttisesti hyväksyttävien suolojensekä niiden valmistuksessa käytettävien uusien välituotteiden valmistamiseksi.
IT1203605B (it) * 1985-04-18 1989-02-15 Alfa Chem Ital Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici

Also Published As

Publication number Publication date
DK554384D0 (da) 1984-11-22
NO160359B (no) 1989-01-02
AU569351B2 (en) 1988-01-28
NO160359C (no) 1990-11-08
DK166271B (da) 1993-03-29
EP0143371A1 (en) 1985-06-05
FI844592L (fi) 1985-05-24
AR241700A1 (es) 1992-11-30
NZ210133A (en) 1988-01-08
YU42907B (en) 1988-12-31
PT79527B (en) 1986-09-08
DE143371T1 (de) 1985-09-26
FI83073B (fi) 1991-02-15
EP0143371B1 (en) 1988-02-24
EP0143371B2 (en) 1995-11-02
KR900001006B1 (ko) 1990-02-24
KR850004092A (ko) 1985-07-01
FI83073C (fi) 1991-05-27
IT1208109B (it) 1989-06-06
IT8303632A0 (it) 1983-11-23
DE3469437D1 (en) 1988-03-31
IE58430B1 (en) 1993-09-22
US4661628A (en) 1987-04-28
NO844647L (no) 1985-05-24
PT79527A (en) 1984-12-01
HU199777B (en) 1990-03-28
YU196784A (en) 1987-06-30
GR81019B (en) 1985-03-22
ES537876A0 (es) 1986-01-16
AU3541284A (en) 1985-06-06
JPS60132930A (ja) 1985-07-16
IL73416A (en) 1990-09-17
CA1226296A (en) 1987-09-01
ATE32601T1 (de) 1988-03-15
HUT36078A (en) 1985-08-28
HU196582B (en) 1988-12-28
ZA848639B (en) 1985-06-26
DK166271C (da) 1993-08-16
FI844592A0 (fi) 1984-11-22
JPH0610155B2 (ja) 1994-02-09
IE842988L (en) 1985-05-23
IL73416A0 (en) 1985-02-28
DK554384A (da) 1985-05-24

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20041029