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ES8602750A1 - Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos - Google Patents

Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos

Info

Publication number
ES8602750A1
ES8602750A1 ES530128A ES530128A ES8602750A1 ES 8602750 A1 ES8602750 A1 ES 8602750A1 ES 530128 A ES530128 A ES 530128A ES 530128 A ES530128 A ES 530128A ES 8602750 A1 ES8602750 A1 ES 8602750A1
Authority
ES
Spain
Prior art keywords
phenylene
alkylene
thio
oxy
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530128A
Other languages
English (en)
Other versions
ES530128A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8602750A1 publication Critical patent/ES8602750A1/es
Publication of ES530128A0 publication Critical patent/ES530128A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-PIRIDIL-INDOLES N-SUSTITUIDOS. UN COMPUESTO DE FORMULA GENERAL (II) DONDE R1 ES HIDROGENO O ALQUILO INFERIOR, R2 Y R3 PUEDEN SER ADEMAS HALOGENO, TRIFLUORMETILO, HIDROXI, ALCOXI INFERIOR, CARBOXIALQUILO INFERIOR, O ALQUILENDIOXI INFERIOR; A SIGNIFICA ALQUILENO Y B CARBOXI, ALCOXI, CARBAMOILO, 5 TETRAZOLILO, ETC. Y AR ES PIRIDILO SUSTITUIDO O NO, SE CALIENTA HASTA 300 C EN PRESENCIA DE UNA BASE PARA OBTENER UN PRODUCTO DE FORMULA (I) QUE POSTERIORMENTE SE TRANSFORMA EN UNA SAL, O SE SEPARAN EN LOS DISTINTOS ISOMENOS. ESTOS COMPUESTOS SON INHIBIDORESDE LA SINTETASA DEL TROMBOXANO.
ES530128A 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos Granted ES530128A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32301881A 1981-11-19 1981-11-19

Publications (2)

Publication Number Publication Date
ES8602750A1 true ES8602750A1 (es) 1985-12-01
ES530128A0 ES530128A0 (es) 1985-12-01

Family

ID=23257445

Family Applications (4)

Application Number Title Priority Date Filing Date
ES517439A Expired ES8501755A1 (es) 1981-11-19 1982-11-17 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos.
ES530126A Granted ES530126A0 (es) 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos
ES530127A Expired ES8608508A1 (es) 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos
ES530128A Granted ES530128A0 (es) 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES517439A Expired ES8501755A1 (es) 1981-11-19 1982-11-17 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos.
ES530126A Granted ES530126A0 (es) 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos
ES530127A Expired ES8608508A1 (es) 1981-11-19 1984-02-28 Procedimiento para la obtencion de 2-piridil-indoles n-sustituidos

Country Status (22)

Country Link
EP (1) EP0080154B1 (es)
JP (1) JPS5892677A (es)
KR (1) KR880002010B1 (es)
AR (3) AR241428A1 (es)
AT (1) ATE15196T1 (es)
AU (1) AU564233B2 (es)
CA (1) CA1197249A (es)
DD (1) DD204924A5 (es)
DE (1) DE3265892D1 (es)
DK (1) DK169104B1 (es)
ES (4) ES8501755A1 (es)
FI (1) FI75344C (es)
GB (1) GB2111050B (es)
GR (1) GR77035B (es)
HU (1) HU190425B (es)
IE (1) IE54156B1 (es)
IL (1) IL67284A (es)
NO (1) NO159929C (es)
NZ (1) NZ202551A (es)
PH (1) PH19212A (es)
PT (1) PT75870B (es)
ZA (1) ZA828505B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8626296D0 (en) * 1986-11-04 1986-12-03 Ici Plc Therapeutic agents
GB9319100D0 (en) * 1993-09-15 1993-11-03 Pfizer Ltd 3-(3-pyridinyl)h-indoles
CA2140722A1 (en) * 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US6828344B1 (en) * 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
GB0307891D0 (en) * 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
SG11202005513TA (en) * 2017-12-15 2020-07-29 Bristol Myers Squibb Co Substituted indole ether compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468894A (en) * 1966-11-29 1969-09-23 Geigy Chem Corp Certain 2-pyridyl-substituted indole derivatives
DE2909779A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue indolderivate, deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
IE54156B1 (en) 1989-07-05
GB2111050A (en) 1983-06-29
KR840002368A (ko) 1984-06-25
IL67284A (en) 1986-03-31
ES517439A0 (es) 1984-12-01
EP0080154A2 (de) 1983-06-01
AR243177A1 (es) 1993-07-30
AU564233B2 (en) 1987-08-06
DK169104B1 (da) 1994-08-15
ZA828505B (en) 1983-09-28
FI75344C (fi) 1988-06-09
NZ202551A (en) 1985-11-08
JPS5892677A (ja) 1983-06-02
PH19212A (en) 1986-02-04
AR241428A1 (es) 1992-07-31
AU9067582A (en) 1983-05-26
ES8601962A1 (es) 1985-11-16
CA1197249A (en) 1985-11-26
EP0080154A3 (en) 1983-09-28
DD204924A5 (de) 1983-12-14
KR880002010B1 (ko) 1988-10-12
GB2111050B (en) 1985-09-11
PT75870A (en) 1982-12-01
DE3265892D1 (en) 1985-10-03
PT75870B (en) 1986-01-21
AR243519A1 (es) 1993-08-31
ES8501755A1 (es) 1984-12-01
ES8608508A1 (es) 1986-06-16
ES530126A0 (es) 1985-11-16
FI823938A0 (fi) 1982-11-17
FI75344B (fi) 1988-02-29
FI823938L (fi) 1983-05-20
DK514182A (da) 1983-05-20
ATE15196T1 (de) 1985-09-15
NO159929B (no) 1988-11-14
GR77035B (es) 1984-09-04
EP0080154B1 (de) 1985-08-28
JPH029031B2 (es) 1990-02-28
NO823869L (no) 1983-05-20
HU190425B (en) 1986-09-29
NO159929C (no) 1989-02-22
ES530128A0 (es) 1985-12-01
ES530127A0 (es) 1986-06-16

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20001102