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ES8405409A1 - Un procedimiento para la preparacion de derivados de b-lactama. - Google Patents

Un procedimiento para la preparacion de derivados de b-lactama.

Info

Publication number
ES8405409A1
ES8405409A1 ES521195A ES521195A ES8405409A1 ES 8405409 A1 ES8405409 A1 ES 8405409A1 ES 521195 A ES521195 A ES 521195A ES 521195 A ES521195 A ES 521195A ES 8405409 A1 ES8405409 A1 ES 8405409A1
Authority
ES
Spain
Prior art keywords
alkyl
beta
haloalkyl
alkoxycarbonyl
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521195A
Other languages
English (en)
Other versions
ES521195A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8405409A1 publication Critical patent/ES8405409A1/es
Publication of ES521195A0 publication Critical patent/ES521195A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE -LACTAMA.CONSISTE EN REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE EL GRUPO AMINO PUEDE ESTAR SUSTITUIDO POR UN GRUPO QUE PERMITA QUE SE DE LA ACILACION Y DONDE RX ES H O UN GRUPO BLOQUEANTE DE CARBOXI, CON UN DERIVADO N-ACILANTE O UN ACIDO DE FORMULA (III), DONDE CUALQUIER GRUPO REACTIVO PUEDE ESTAR PROTEGIDO PARA PRODUCIR DERIVADOS DE -LACTAMA DE FORMULA (I). DONDE R ES H O (ELQUIL C 1 A 6) CARBONILO Y OTRNS; R ES H, HALOGENO, HIDROXI U OTROS; R ES HALOGENO, HIDROXI Y OTROS. LA REACCION SE REALIZA ENTREG50JC EN MEDIO ACUOSO O NO, TAL COMO ACETONA. LA COMPOSICION EN PESO PUEDE TENER ENTRE EL 10 Y EL 60 DEL PRODUCTO ACTIVO. POSTERIORMENTE SE PUEDE: A) SEPARAR CUALQUIER RX BLOQUEANTE DE CARBOXI; B) SEPARAR CUALQUIER SUSTITUYENTE EN EL GRUPO AMIDO; C) SEPARAR CUALQUIER GRUPO PROTECTOR EN EL ACIDO DE FORMULA (III); O D) CONVERTIR EL PRODUCTO EN SAL O ESTER HIDROLIZABLE IN VIVO DEL MISMO.TIENE APLICACIONES ANTIBACTERIANAS, PARTICULARMENTE CONTRA GRAM-NEGATIVAS.
ES521195A 1982-04-03 1983-03-30 Un procedimiento para la preparacion de derivados de b-lactama. Granted ES521195A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8209982 1982-04-03

Publications (2)

Publication Number Publication Date
ES8405409A1 true ES8405409A1 (es) 1984-06-01
ES521195A0 ES521195A0 (es) 1984-06-01

Family

ID=10529521

Family Applications (2)

Application Number Title Priority Date Filing Date
ES521195A Granted ES521195A0 (es) 1982-04-03 1983-03-30 Un procedimiento para la preparacion de derivados de b-lactama.
ES527806A Granted ES527806A0 (es) 1982-04-03 1983-12-05 Un procedimiento para la preparacion de derivados de -lactama

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES527806A Granted ES527806A0 (es) 1982-04-03 1983-12-05 Un procedimiento para la preparacion de derivados de -lactama

Country Status (5)

Country Link
EP (1) EP0091302A1 (es)
JP (1) JPS58185592A (es)
AU (1) AU1308883A (es)
ES (2) ES521195A0 (es)
ZA (1) ZA832360B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3479731D1 (en) * 1983-07-07 1989-10-19 Beecham Group Plc Substituted phenylglycine derivatives of beta-lactam antibiotics
GB2168974A (en) * 1984-12-20 1986-07-02 Procter & Gamble Compounds and compositions having anti-inflammatory activity
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
CN104341307B (zh) * 2013-08-05 2016-12-28 北京京朋汇药业研究发展有限公司 苯乙酸衍生物及其抗肿瘤用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308259A (en) * 1979-03-01 1981-12-29 Beecham Group Limited Penicillin derivatives
DE3262616D1 (en) * 1981-05-22 1985-04-25 Beecham Group Plc Beta-lactam derivatives, a process for their preparation and compositions containing them

Also Published As

Publication number Publication date
JPS58185592A (ja) 1983-10-29
AU1308883A (en) 1983-10-06
ES521195A0 (es) 1984-06-01
ZA832360B (en) 1984-03-28
ES8506722A1 (es) 1985-08-01
ES527806A0 (es) 1985-08-01
EP0091302A1 (en) 1983-10-12

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