ES8602665A1 - Un procedimiento para la obtencion de medicamentos a base dederivados de la 1,4-dihidropiridina - Google Patents
Un procedimiento para la obtencion de medicamentos a base dederivados de la 1,4-dihidropiridinaInfo
- Publication number
- ES8602665A1 ES8602665A1 ES540811A ES540811A ES8602665A1 ES 8602665 A1 ES8602665 A1 ES 8602665A1 ES 540811 A ES540811 A ES 540811A ES 540811 A ES540811 A ES 540811A ES 8602665 A1 ES8602665 A1 ES 8602665A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkoxy
- halogen
- amino
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- ZZTCXIRXNXSQBO-UHFFFAOYSA-N 2,6-dimethyl-5-nitro-4-phenyl-1,4-dihydropyridine-3-carboxamide Chemical compound CC=1NC(=C(C(C1C(=O)N)C1=CC=CC=C1)[N+](=O)[O-])C ZZTCXIRXNXSQBO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE MEDICAMENTOS A BASE DE DERIVADOS DE LA 1,4, -DIHIDROPIRIDINA DE FORMULA (I).CONSISTE EN: A) HACER REACCIONAR DIHIDROPIRIDINAS DE FORMULA (VI) CON UNA AMINA O SE TRANSFORMA EN UN DERIVADO REACTIVO DE ACIDO, COMO UN ESTER ACTIVADO, ESTER DE HIDROXISUCCINIMIDA O IMIDAZOLIDOS DE ACIDO Y ESTE SE HACE REACCIONAR CON AMINAS DE FORMULA (VII), EN DISOLVENTE ORGANICO INERTE Y A TEMPERATURA ENTRE 20 Y 150 C PARA OBTENER EL PRODUCTO (I) DONDE R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y SIGNIFICAN HIDROGENO O ALQUILO C1-C4 U OTROS VARIOS RADICALES, R2 Y R3 SON IGUALES O DIFERENTES Y SIGNIFICAN HIDROGENO O RESTO ALQUILO C1-C4 U OTROS VARIOS RADICALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833319956 DE3319956A1 (de) | 1983-06-01 | 1983-06-01 | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8602665A1 true ES8602665A1 (es) | 1985-12-01 |
| ES540811A0 ES540811A0 (es) | 1985-12-01 |
Family
ID=6200484
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532791A Expired ES8506626A1 (es) | 1983-06-01 | 1984-05-24 | Derivados de la 1, 4-dihidropiridina |
| ES540810A Granted ES540810A0 (es) | 1983-06-01 | 1985-02-28 | Un procedimiento para la obtencion de medicamentos a base de derivados de la 1,4-dihidropiridina. |
| ES540811A Granted ES540811A0 (es) | 1983-06-01 | 1985-02-28 | Un procedimiento para la obtencion de medicamentos a base dederivados de la 1,4-dihidropiridina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532791A Expired ES8506626A1 (es) | 1983-06-01 | 1984-05-24 | Derivados de la 1, 4-dihidropiridina |
| ES540810A Granted ES540810A0 (es) | 1983-06-01 | 1985-02-28 | Un procedimiento para la obtencion de medicamentos a base de derivados de la 1,4-dihidropiridina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4540684A (es) |
| EP (1) | EP0127826B1 (es) |
| JP (1) | JPS59227860A (es) |
| KR (1) | KR850000397A (es) |
| AT (1) | ATE54309T1 (es) |
| AU (1) | AU569298B2 (es) |
| CA (1) | CA1242706A (es) |
| DE (2) | DE3319956A1 (es) |
| DK (1) | DK269784A (es) |
| ES (3) | ES8506626A1 (es) |
| HU (1) | HU191665B (es) |
| IL (1) | IL71950A (es) |
| ZA (1) | ZA844118B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3315805A1 (de) | 1983-04-30 | 1984-11-08 | Bayer Ag, 5090 Leverkusen | Wirkstoffzubereitungen |
| DE3348281C2 (en) * | 1983-04-30 | 1989-06-15 | Bayer Ag, 5090 Leverkusen, De | Microemulsion of non lipoid surfactant and partly miscible solvent |
| EP0145956A1 (de) * | 1983-11-16 | 1985-06-26 | Ciba-Geigy Ag | Neue Amid-Verbindungen |
| DE3420784A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3445852A1 (de) * | 1984-12-15 | 1986-06-19 | Bayer Ag, 5090 Leverkusen | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JPS62174050A (ja) * | 1985-10-21 | 1987-07-30 | Nippon Shoji Kk | ３−アミノカルボニル−１，４−ジヒドロピリジン−５−カルボン酸誘導体、その製法および医薬組成物 |
| US5064580A (en) * | 1988-03-31 | 1991-11-12 | The Dow Chemical Company | Process for making microporous membranes from poly(etheretherketone)-type polymers |
| US5227101A (en) * | 1988-03-31 | 1993-07-13 | The Dow Chemical Company | Process of making microporous membranes from poly(etheretherketone)-type polymers and low melting point crystallizable polymers |
| US5205968A (en) * | 1988-03-31 | 1993-04-27 | The Dow Chemical Company | Process for making a microporous membrane from a blend containing a poly(etheretherketone)-type polymer, an amorphous polymer, and a solvent |
| US4904426A (en) * | 1988-03-31 | 1990-02-27 | The Dow Chemical Company | Process for the production of fibers from poly(etheretherketone)-type polymers |
| CA2069877A1 (en) * | 1990-10-02 | 1992-04-03 | Michio Nakanishi | Ethynylphenyl derivative substituted by pyridazinone and medicament for circulatory disease containing the same as an effective ingredient |
| EP1191022A4 (en) * | 1999-06-23 | 2002-09-18 | Ajinomoto Kk | NEW DIHYDROPYRIDINE DERIVATIVES |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2228377A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
| DE2752820A1 (de) * | 1977-11-26 | 1979-05-31 | Bayer Ag | Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
-
1983
- 1983-06-01 DE DE19833319956 patent/DE3319956A1/de not_active Withdrawn
-
1984
- 1984-05-18 US US06/612,093 patent/US4540684A/en not_active Expired - Fee Related
- 1984-05-19 AT AT84105726T patent/ATE54309T1/de not_active IP Right Cessation
- 1984-05-19 DE DE8484105726T patent/DE3482626D1/de not_active Expired - Lifetime
- 1984-05-19 EP EP84105726A patent/EP0127826B1/de not_active Expired - Lifetime
- 1984-05-24 ES ES532791A patent/ES8506626A1/es not_active Expired
- 1984-05-25 AU AU28709/84A patent/AU569298B2/en not_active Ceased
- 1984-05-29 IL IL71950A patent/IL71950A/xx unknown
- 1984-05-30 DK DK269784A patent/DK269784A/da not_active Application Discontinuation
- 1984-05-30 JP JP59108711A patent/JPS59227860A/ja active Pending
- 1984-05-30 ZA ZA844118A patent/ZA844118B/xx unknown
- 1984-05-30 CA CA000455418A patent/CA1242706A/en not_active Expired
- 1984-05-31 KR KR1019840003032A patent/KR850000397A/ko not_active Ceased
- 1984-05-31 HU HU842134A patent/HU191665B/hu unknown
-
1985
- 1985-02-28 ES ES540810A patent/ES540810A0/es active Granted
- 1985-02-28 ES ES540811A patent/ES540811A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU569298B2 (en) | 1988-01-28 |
| DK269784D0 (da) | 1984-05-30 |
| IL71950A0 (en) | 1984-09-30 |
| KR850000397A (ko) | 1985-02-27 |
| IL71950A (en) | 1987-10-20 |
| EP0127826A3 (en) | 1987-07-29 |
| US4540684A (en) | 1985-09-10 |
| ES532791A0 (es) | 1985-07-16 |
| ZA844118B (en) | 1985-02-27 |
| ATE54309T1 (de) | 1990-07-15 |
| JPS59227860A (ja) | 1984-12-21 |
| DE3319956A1 (de) | 1984-12-06 |
| EP0127826B1 (de) | 1990-07-04 |
| HUT34447A (en) | 1985-03-28 |
| DE3482626D1 (de) | 1990-08-09 |
| ES8602660A1 (es) | 1985-12-01 |
| ES540811A0 (es) | 1985-12-01 |
| HU191665B (en) | 1987-03-30 |
| EP0127826A2 (de) | 1984-12-12 |
| ES8506626A1 (es) | 1985-07-16 |
| CA1242706A (en) | 1988-10-04 |
| ES540810A0 (es) | 1985-12-01 |
| AU2870984A (en) | 1984-12-06 |
| DK269784A (da) | 1984-12-02 |
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