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ES8601100A1 - Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina - Google Patents

Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina

Info

Publication number
ES8601100A1
ES8601100A1 ES532710A ES532710A ES8601100A1 ES 8601100 A1 ES8601100 A1 ES 8601100A1 ES 532710 A ES532710 A ES 532710A ES 532710 A ES532710 A ES 532710A ES 8601100 A1 ES8601100 A1 ES 8601100A1
Authority
ES
Spain
Prior art keywords
erythro
dihydroxyphenyl
racemic
optically active
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532710A
Other languages
English (en)
Other versions
ES532710A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58092941A external-priority patent/JPS59216858A/ja
Priority claimed from JP59027827A external-priority patent/JPS60169462A/ja
Priority claimed from JP2782884A external-priority patent/JPS60169452A/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES532710A0 publication Critical patent/ES532710A0/es
Publication of ES8601100A1 publication Critical patent/ES8601100A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 3-(34-DIHIDROXIFENIL)SERINA. CONSISTE EN LA REACCION DE UN ACIDO DE LEWIS CON UN DERIVADO DE N-FTALOIL-3-(34-DIHIDROXIFENIL)SERINA DE FORMULA (I) EN LA QUE R1 Y R2 PUEDEN SER HIDROGENO O METILO O FORMAR JUNTOS UN GRUPO METILENO; REACCION QUE SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE EN PRESENCIA DE 1 A 5 MOLES DE UN MERCAPTANO QUE TIENE 1 A 20 ATOMOS DE CARBONO A UNA TEMPERATURA ENTRE C10 Y 30JC; SEGUIDA DE LA SEPARACION DEL GRUPO FTALOILO DEL COMPUESTO FORMADO. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA HIPOTENSION ORTOSTATICA PERIFERICA COMO ANTIDEPRESIVO Y ANTIPARKINSONIANO.
ES532710A 1983-05-25 1984-05-23 Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina Expired ES8601100A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58092941A JPS59216858A (ja) 1983-05-25 1983-05-25 スレオ−３−（３，４−ジヒドロキシフエニル）セリンの製造法
JP59027827A JPS60169462A (ja) 1984-02-15 1984-02-15 光学活性なフエニルセリン誘導体の製造法
JP2782884A JPS60169452A (ja) 1984-02-15 1984-02-15 エリスロ−３−（３，４−ジヒドロキシフエニル）セリンの製造法

Publications (2)

Publication Number Publication Date
ES532710A0 ES532710A0 (es) 1985-10-16
ES8601100A1 true ES8601100A1 (es) 1985-10-16

Family

ID=27285964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532710A Expired ES8601100A1 (es) 1983-05-25 1984-05-23 Un procedimiento para producir 3-(3, 4-dihidroxifenil) serina

Country Status (5)

Country Link
US (1) US4562263A (es)
EP (1) EP0128684B1 (es)
CA (1) CA1223602A (es)
DE (1) DE3468679D1 (es)
ES (1) ES8601100A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6259274A (ja) * 1985-05-29 1987-03-14 Sumitomo Pharmaceut Co Ltd 光学活性なフエニルセリン誘導体の製造方法
JPS62192357A (ja) * 1986-02-19 1987-08-22 Kureha Chem Ind Co Ltd Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
US5952512A (en) * 1995-07-24 1999-09-14 Takeda Chemical Industries, Ltd. Production of optically active benzothiepin salts
MY117687A (en) * 1996-10-31 2004-07-31 Bayer Corp Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors
US6403645B2 (en) 2000-03-16 2002-06-11 President And Fellows Of Harvard College Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them
WO2003016245A1 (en) * 2001-08-17 2003-02-27 Degussa Ag Chromatographic separation of enantiomers of protected amino acids via smb-method
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
US20060105036A1 (en) 2003-05-12 2006-05-18 Stephen Peroutka Threo-dops controlled release formulation
WO2005025561A1 (en) * 2003-09-04 2005-03-24 Synergia Pharma, Inc. Compositions and methods for orthostatic intolerance
US20080015181A1 (en) 2006-06-28 2008-01-17 Chelsea Therapeutics, Inc. Pharmaceutical Compositions Comprising Droxidopa
KR20100014392A (ko) 2007-03-09 2010-02-10 첼시 쎄라퓨틱스, 인코포레이티드 섬유근통 치료용 드록시도파 및 약학 조성물
AU2008248382B2 (en) * 2007-05-07 2013-07-18 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
US8598370B2 (en) * 2009-07-01 2013-12-03 Dainippon Sumitomo Pharma Co., Ltd. Process for producing threo-3-(3,4-dihydroxyphenyl)-L-serine
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状（姿勢反射異常）の治療剤
WO2013116325A1 (en) 2012-01-31 2013-08-08 Chelsea Therapeutics, Inc. Improving postural stability administering droxidopa
US20130253061A1 (en) 2012-03-20 2013-09-26 Chelsea Therapeutics, Inc. Method of droxidopa synthesis
CN105473545B (zh) 2013-07-08 2017-08-04 奥斯拜客斯制药有限公司 二羟苯基神经递质化合物、组合物以及方法
EP3436426A4 (en) 2016-03-30 2020-03-04 Piramal Enterprises Limited IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE
US9920342B2 (en) 2016-05-17 2018-03-20 Divi's Laboratories Limited Process for the preparation of Droxidopa
CN109956922B (zh) * 2017-12-25 2021-12-10 重庆圣华曦药业股份有限公司 屈昔多巴关键中间体的拆分方法
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT205027B (de) * 1957-07-18 1959-08-25 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von neuen α-Aroyl-α-phthaliminoessigsäureestern
CH505785A (de) * 1969-02-07 1971-04-15 Hoffmann La Roche Verfahren zur Herstellung von (-)threo-3-(4-Hydroxy-3-methoxy-phenyl)-serin
CH580059A5 (es) * 1973-08-22 1976-09-30 Hoffmann La Roche
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
JPS5419931A (en) * 1977-07-11 1979-02-15 Sumitomo Chem Co Ltd Separation of threo, erythro-3-(3,4-dibenzyloxyphenyl)serines
DD140036A1 (de) * 1978-05-03 1987-02-11 Adw Ddr Verfahren zur herstellung optisch aktiver aminosaeuren und ihrer derivate
FR2430413A1 (fr) * 1978-07-07 1980-02-01 Anvar Procede de preparation d'alpha-aminoacides optiquement actifs, et leurs derives
JPS5629551A (en) * 1979-08-20 1981-03-24 Sumitomo Chem Co Ltd Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine
DE3360726D1 (en) * 1982-01-14 1985-10-17 Sumitomo Chemical Co Process for producing threo-3-(3,4-dihydroxyphenyl)serine

Also Published As

Publication number Publication date
EP0128684A1 (en) 1984-12-19
US4562263A (en) 1985-12-31
ES532710A0 (es) 1985-10-16
CA1223602A (en) 1987-06-30
EP0128684B1 (en) 1988-01-13
DE3468679D1 (en) 1988-02-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030312