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ES8506293A1 - Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles - Google Patents

Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Info

Publication number
ES8506293A1
ES8506293A1 ES529312A ES529312A ES8506293A1 ES 8506293 A1 ES8506293 A1 ES 8506293A1 ES 529312 A ES529312 A ES 529312A ES 529312 A ES529312 A ES 529312A ES 8506293 A1 ES8506293 A1 ES 8506293A1
Authority
ES
Spain
Prior art keywords
benzisoxazoles
piperidyl
substituted
preparation
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529312A
Other languages
English (en)
Other versions
ES529312A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8506293A1 publication Critical patent/ES8506293A1/es
Publication of ES529312A0 publication Critical patent/ES529312A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 3-(1-SUSTITUIDO-4-PIPERIDIL)-1,2-BENCISOXAZOLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN PRESENCIA DE UN ACEPTOR ACIDO, UN ACTIVADOR DE DESPLAZAMIENTO Y UN DISOLVENTE ADECUADO, CON 3-8-FENILSULFONILALCOHIL)INDOL O UN 3-(ALCOHILFENILSULFONILALCOHIL)INDOL DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (I) DONDE X ES HALOGENO, ALCOHILO INFERIOR O HIDROXI; Y R ES UN GRUPO DE FORMULA (IV).SE UTILIZAN PARA EL TRATAMIENTO DE LA PSICOSIS, SOLOS O EN COMBINACION CON AUXILIARES INERTES DEL TRATAMIENTO DE LA PSICOSIS.
ES529312A 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles Granted ES529312A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/319,872 US4352811A (en) 1981-11-12 1981-11-12 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Publications (2)

Publication Number Publication Date
ES8506293A1 true ES8506293A1 (es) 1985-07-01
ES529312A0 ES529312A0 (es) 1985-07-01

Family

ID=23243961

Family Applications (5)

Application Number Title Priority Date Filing Date
ES517249A Granted ES517249A0 (es) 1981-11-12 1982-11-10 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles.
ES529313A Granted ES529313A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529312A Granted ES529312A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529315A Granted ES529315A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529314A Expired ES8506705A1 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES517249A Granted ES517249A0 (es) 1981-11-12 1982-11-10 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1,2-bencisoxazoles.
ES529313A Granted ES529313A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES529315A Granted ES529315A0 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
ES529314A Expired ES8506705A1 (es) 1981-11-12 1984-01-31 Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles

Country Status (17)

Country Link
US (1) US4352811A (es)
EP (1) EP0079564B1 (es)
JP (1) JPS5890583A (es)
AT (1) ATE18669T1 (es)
AU (1) AU556307B2 (es)
CA (1) CA1196334A (es)
DE (1) DE3270015D1 (es)
DK (1) DK503082A (es)
ES (5) ES517249A0 (es)
FI (1) FI823860L (es)
GR (1) GR78402B (es)
HU (1) HU191366B (es)
IL (1) IL67235A (es)
NO (1) NO823775L (es)
NZ (1) NZ202457A (es)
PT (1) PT75848A (es)
ZA (1) ZA828278B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US4469869A (en) * 1982-08-11 1984-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(4-Piperidinium)-1,2-benzisoxazoles
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4524074A (en) * 1983-05-31 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4528292A (en) * 1984-04-23 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive 1,2-benzisothiazole piperidines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
SK282231B6 (sk) * 1993-11-19 2001-12-03 Janssen Pharmaceutica N. V. Farmaceutický prostriedok na liečenie psychotických porúch
ES2074966B1 (es) * 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DK1054885T3 (da) 1998-02-09 2007-10-15 Duphar Int Res Benzisoxasolderivater med D4-antagonistisk virkning
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
CA2543242C (en) * 2003-10-23 2015-04-14 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile freeze-dried aripiprazole formulation and injectable formulation thereof
US8816090B2 (en) * 2005-02-25 2014-08-26 Pfizer Inc. Benzisoxazole derivatives
PT2170279T (pt) * 2007-07-31 2018-04-06 Otsuka Pharma Co Ltd Métodos para produção de suspensão de aripiprazole e formulação liofilizada
PL2079446T3 (pl) * 2007-08-21 2012-04-30 Teva Pharma Preparat paliperidonu o przedłużonym uwalnianiu
CN101759693B (zh) * 2008-12-23 2011-09-14 江苏恩华药业股份有限公司 苯骈异恶唑哌啶衍生物及在制备镇痛、镇静药物中的应用
WO2016071723A1 (en) * 2014-11-03 2016-05-12 Sifavitor S.R.L. Process for the preparation of a fluspirilene intermediate
CN104829591B (zh) * 2015-04-27 2017-05-03 梯尔希（南京）药物研发有限公司 氘代匹莫齐特的制备方法
WO2024259250A2 (en) * 2023-06-16 2024-12-19 Transneural Therapeutics, Inc. 5-ht2a receptor modulators and methods of use thereof
WO2025174820A1 (en) * 2024-02-12 2025-08-21 Ohio State Innovation Foundation Heteroaryl topoisomerase inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (es) * 1962-06-13
US3678062A (en) * 1970-09-08 1972-07-18 American Cyanamid Co Certain 4-/(indazol-3-yl)-pyridinium/compounds
JPS5545545B2 (es) * 1972-03-17 1980-11-18
US4217349A (en) * 1974-07-01 1980-08-12 Sumitomo Chemical Company, Limited Benzisoxazole derivatives
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Also Published As

Publication number Publication date
AU9039182A (en) 1983-05-19
ES8506658A1 (es) 1985-08-01
IL67235A (en) 1987-03-31
PT75848A (en) 1982-12-01
JPS5890583A (ja) 1983-05-30
CA1196334A (en) 1985-11-05
ES529314A0 (es) 1985-08-01
NO823775L (no) 1983-05-13
US4352811A (en) 1982-10-05
ES8506657A1 (es) 1985-07-16
ZA828278B (en) 1983-09-28
DE3270015D1 (en) 1986-04-24
HU191366B (en) 1987-02-27
EP0079564B1 (en) 1986-03-19
EP0079564A1 (en) 1983-05-25
ES529315A0 (es) 1985-08-01
FI823860A0 (fi) 1982-11-10
IL67235A0 (en) 1983-03-31
ATE18669T1 (de) 1986-04-15
DK503082A (da) 1983-05-13
ES8506705A1 (es) 1985-08-01
AU556307B2 (en) 1986-10-30
GR78402B (es) 1984-09-27
ES529313A0 (es) 1985-07-16
FI823860A7 (fi) 1983-05-13
FI823860L (fi) 1983-05-13
NZ202457A (en) 1986-05-09
ES8405396A1 (es) 1984-06-01
ES529312A0 (es) 1985-07-01
ES517249A0 (es) 1984-06-01

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