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ES8505819A1 - Un procedimiento de una vacuna capaz de inducir la produccion de anticuerpos de reaccion con mas de una cepa de virus dela influenza. - Google Patents

Un procedimiento de una vacuna capaz de inducir la produccion de anticuerpos de reaccion con mas de una cepa de virus dela influenza.

Info

Publication number
ES8505819A1
ES8505819A1 ES525088A ES525088A ES8505819A1 ES 8505819 A1 ES8505819 A1 ES 8505819A1 ES 525088 A ES525088 A ES 525088A ES 525088 A ES525088 A ES 525088A ES 8505819 A1 ES8505819 A1 ES 8505819A1
Authority
ES
Spain
Prior art keywords
clurality
antisera
broad spectrum
boc
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525088A
Other languages
English (en)
Other versions
ES525088A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of ES8505819A1 publication Critical patent/ES8505819A1/es
Publication of ES525088A0 publication Critical patent/ES525088A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K16/108—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA VACUNA CAPAZ DE INDUCIR LA PRODUCCION DE ANTICUERPOS QUE REACCIONAN CON MAS DE UNA CEPA DEL VIRUS DE LA INFLUENZA.COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE PREPARA UNA RESINA INSOLUBLE QUE CONTIENE UNA PLURALIDAD DE GRUPOS CLOROMETILO Y SE LA ESTERIFICA BOC(MEOBZL)0CYS-OH; SEGUNDA, SE SEPARA EL GRUPO BOC PARA OBTENER UN GRUPO AMINO LIBRE SOBRE LE RESTO CYS; TERCERA, SE HACE REACCIONAR LA AMINA LIBRE CON UN EXCESO DE OTRO AMINOACIDO QUE CONTENGA UN GRUPO CARBOXILO LIBRE; Y POR ULTIMO, SE SINTETIZA UN PEPTIDO PROTEGIDO DE UNA SECUENCIA DETERMINADA Y SE LE HACE REACCIONAR CON UN PORTADOR PARA FORMAR UN CONJUGADO, EL CUAL SE DISUELVE EN UN DILUYENTE FISIOLOGICO PARA FORMAR LA VACUNA.
ES525088A 1982-08-23 1983-08-22 Un procedimiento de una vacuna capaz de inducir la produccion de anticuerpos de reaccion con mas de una cepa de virus dela influenza. Granted ES525088A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41045582A 1982-08-23 1982-08-23

Publications (2)

Publication Number Publication Date
ES8505819A1 true ES8505819A1 (es) 1985-06-16
ES525088A0 ES525088A0 (es) 1985-06-16

Family

ID=23624803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525088A Granted ES525088A0 (es) 1982-08-23 1983-08-22 Un procedimiento de una vacuna capaz de inducir la produccion de anticuerpos de reaccion con mas de una cepa de virus dela influenza.

Country Status (16)

Country Link
EP (1) EP0116629A4 (es)
JP (1) JPS59501714A (es)
KR (1) KR840006198A (es)
AU (1) AU570929B2 (es)
DK (1) DK203684D0 (es)
ES (1) ES525088A0 (es)
FI (1) FI841583L (es)
GR (1) GR78931B (es)
IL (1) IL69556A (es)
IT (1) IT1168636B (es)
NO (1) NO161002C (es)
NZ (2) NZ220612A (es)
PH (1) PH18872A (es)
PT (1) PT77230B (es)
WO (1) WO1984000687A1 (es)
ZA (1) ZA836080B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241713A1 (es) * 1984-08-30 1992-11-30 Smithkline Beckman Corp Molecula de dna con una secuencia de bases que codifica la proteina c13 y preparacion de vacunas contra la gripe.
US5866363A (en) 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
WO1990008161A1 (en) * 1989-01-12 1990-07-26 The Blood Center Of Southeastern Wisconsin Peptide-mediated modulation of t-cell recognition as a means of affecting immune responses
EP0621339B1 (en) * 1992-09-17 2001-10-24 Takara Shuzo Co. Ltd. Immunogenic human influenza A virus haemagglutinin polypeptides
JP2996864B2 (ja) * 1994-03-30 2000-01-11 寳酒造株式会社 抗体可変領域ｄｎａ
US8148085B2 (en) 2006-05-15 2012-04-03 Sea Lane Biotechnologies, Llc Donor specific antibody libraries
CN103435697A (zh) * 2006-05-15 2013-12-11 航道生物技术有限责任公司 流感病毒的中和抗体
HRP20130163T1 (hr) * 2006-09-07 2013-03-31 Crucell Holland B.V. Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba
ITTO20070066A1 (it) 2007-01-30 2008-07-31 Pomona Biotechnologies Llc Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv
WO2008118970A2 (en) 2007-03-27 2008-10-02 Sea Lane Biotechnologies, Llc Constructs and libraries comprising antibody surrogate light chain sequences
ITTO20080204A1 (it) 2008-03-17 2009-09-18 Pomona Biotechnologies Llc Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a
US20100040635A1 (en) 2008-03-28 2010-02-18 Sea Lane Biotechnologies Neutralizing antibodies to influenza viruses
ITTO20080398A1 (it) 2008-05-27 2009-11-28 Pomona Biotechnologies Llc Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1
ITTO20080964A1 (it) 2008-12-22 2010-06-23 Natimab Therapeutics S R L Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv
EP2380976A4 (en) 2008-12-25 2012-11-07 Univ Osaka HUMAN ANTIBODY AGAINST HUMAN FLUX VIRUS
EP2413962A1 (en) 2009-03-30 2012-02-08 Mount Sinai School of Medicine Influenza virus vaccines and uses thereof
WO2010132604A2 (en) 2009-05-13 2010-11-18 Sea Lane Biotechnologies, Llc Neutralizing molecules to influenza viruses
EP2435475B1 (en) 2009-05-26 2018-10-17 Icahn School of Medicine at Mount Sinai Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof
IT1395961B1 (it) 2009-06-01 2012-11-02 Pomona Biotechnologies Llc Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv)
CN102939096B (zh) * 2010-02-18 2016-03-02 西奈山医学院 用于预防和治疗流感病毒疾病的疫苗
US9708373B2 (en) 2010-03-30 2017-07-18 Icahn School Of Medicine At Mount Sinai Influenza virus vaccine and uses thereof
WO2013016714A1 (en) 2011-07-28 2013-01-31 Sea Lane Biotechnologies Sur-binding proteins against erbb3
ES2953393T3 (es) 2011-09-20 2023-11-10 Icahn School Med Mount Sinai Vacunas contra el virus de la influenza y sus usos
EP2793940B1 (en) 2011-12-22 2018-11-14 i2 Pharmaceuticals, Inc. Surrogate binding proteins
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
CN108641002A (zh) 2012-12-18 2018-10-12 西奈山伊坎医学院 流感病毒疫苗及其用途
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
EP3247389A4 (en) 2015-01-23 2019-10-30 Icahn School of Medicine at Mount Sinai INFLUENZAVIRUSSCHUTZIMPFPLÄNE
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN109195629A (zh) 2016-02-24 2019-01-11 威特拉公司 流行性感冒抗体分子制剂
JP7237344B2 (ja) 2016-06-15 2023-03-13 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルス血球凝集素タンパク質及びその使用
US11254733B2 (en) 2017-04-07 2022-02-22 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
EP3810634A4 (en) 2018-06-21 2022-07-27 Icahn School of Medicine at Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
JP2022521819A (ja) 2019-03-25 2022-04-12 ビステラ， インコーポレイテッド インフルエンザを処置および予防するための組成物および方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI83662C (fi) * 1980-07-17 1991-08-12 Scripps Clinic Res Diagnostik antikropp och foerfarande foer dess framstaellning.

Also Published As

Publication number Publication date
NZ220612A (en) 1988-07-28
IT8348868A0 (it) 1983-08-22
GR78931B (es) 1984-10-02
IT1168636B (it) 1987-05-20
ZA836080B (en) 1984-04-25
IT8348868A1 (it) 1985-02-22
AU570929B2 (en) 1988-03-31
NO161002C (no) 1989-06-21
IL69556A (en) 1988-05-31
EP0116629A4 (en) 1987-06-29
PT77230B (en) 1986-02-04
ES525088A0 (es) 1985-06-16
AU1947183A (en) 1984-03-07
NO841540L (no) 1984-04-17
KR840006198A (ko) 1984-11-22
WO1984000687A1 (en) 1984-03-01
JPS59501714A (ja) 1984-10-11
NO161002B (no) 1989-03-13
PT77230A (en) 1983-09-01
EP0116629A1 (en) 1984-08-29
NZ205341A (en) 1988-07-28
PH18872A (en) 1985-10-21
DK203684A (da) 1984-04-18
FI841583A0 (fi) 1984-04-19
IL69556A0 (en) 1983-11-30
FI841583A7 (fi) 1984-04-19
FI841583L (fi) 1984-04-19
DK203684D0 (da) 1984-04-18

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