ES8502992A1 - PROCEDURE FOR THE PREPARATION OF A (TIO) -ETER OF 2-METHYL-LISERG-8-ILO - Google Patents
PROCEDURE FOR THE PREPARATION OF A (TIO) -ETER OF 2-METHYL-LISERG-8-ILOInfo
- Publication number
- ES8502992A1 ES8502992A1 ES524815A ES524815A ES8502992A1 ES 8502992 A1 ES8502992 A1 ES 8502992A1 ES 524815 A ES524815 A ES 524815A ES 524815 A ES524815 A ES 524815A ES 8502992 A1 ES8502992 A1 ES 8502992A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- ilo
- tio
- formula
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN (TIO)-ETER DE 2-METIL-LISERG-8-ILO.COMPRENDE REEMPLAZAR EL GRUPO Y EN UN DERIVADO 8-CH2Y CORRESPONDIENTE EN EL QUE Y ES UN GRUPO SUSCEPTIBLE DE SER ELIMINADO, TAL COMO UN COMPUESTO DE FORMULA (II), POR UN RADICAL ETER O TIOETER, TAL COMO UN GRUPO DE FORMULA (III) Y RECUPERAR EL COMPUESTO DE FORMULA (I) EN FORMA DE UNA SAL DE ADICION DEL MISMO, EN LA QUE X SIQNIFICA O O S; R1 SIGNIFICA H, ALQUILO C 1 A 4 O FENILO; R2 SIGNIFICA ALQUILO C 1 A 3 Y R3 SIGNIFICA FENILO O PIRIDILO, SIS SUSTITUIR O LLEVANDO CADA UNO, UNO, DOS O TRES SUSTITUYENTES ELEGIDOS ENTRE UN NUMERO ATOMICO DE 9 A 35, ALQUILO C 1 A 4 Y ALCOXI C 1 A 4, O REPRESENTA ALQUILO C 1 A 4 Y SALES DE ADICION DE ACIDOS DE LOS COMPUESTOS. LA REACCION SE REALIZA A TEMPERATURA ENTRE 50 Y 100JC Y EN UNA ATMOSFERA DE UN GAS INERTE COMO NITROGENO.PROCEDURE FOR THE PREPARATION OF A (TIO)-ETHER OF 2-METHYL-LYSERG-8-ILO. INCLUDES REPLACING THE GROUP AND IN A CORRESPONDING 8-CH2Y DERIVATIVE IN WHICH AND IS A GROUP LIKELY TO BE ELIMINATED, SUCH AS A COMPOUND OF FORMULA (II), BY AN ETHER OR TIOETHER RADICAL, SUCH AS A GROUP OF FORMULA (III) AND RECOVERING THE COMPOUND OF FORMULA (I) IN THE FORM OF AN ADDITION SALT THEREOF, IN WHICH X STANDS FOR O OR S; R1 SIGNIFIES H, C 1 TO 4 ALKYL OR PHENYL; R2 MEANS C 1 TO 3 ALKYL AND R3 MEANS PHENYL OR PYRIDYL, WITHOUT SUBSTITUTING OR CARRYING EACH ONE, ONE, TWO OR THREE SUBSTITUENTS CHOSEN BETWEEN AN ATOMIC NUMBER OF 9 TO 35, C 1 TO 4 ALKYL AND C 1 TO 4 ALCOXY, OR REPRESENTS ALKYC 1 TO 4 AND ACID ADDITION SALTS OF THE COMPOUNDS. THE REACTION IS CARRIED OUT AT A TEMPERATURE BETWEEN 50 AND 100JC AND IN AN ATMOSPHERE OF AN INERT GAS SUCH AS NITROGEN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4772/82A CH649998A5 (en) | 1982-08-09 | 1982-08-09 | ERGOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND HEALING AGENTS, CONTAINING THESE ERGOL DERIVATIVES AS AN ACTIVE SUBSTANCE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502992A1 true ES8502992A1 (en) | 1985-02-01 |
| ES524815A0 ES524815A0 (en) | 1985-02-01 |
Family
ID=4282273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524815A Granted ES524815A0 (en) | 1982-08-09 | 1983-08-08 | PROCEDURE FOR THE PREPARATION OF A (TIO) -ETER OF 2-METHYL-LISERG-8-ILO |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5948480A (en) |
| AT (1) | AT383125B (en) |
| AU (1) | AU563736B2 (en) |
| BE (1) | BE897473A (en) |
| CA (1) | CA1215972A (en) |
| CH (1) | CH649998A5 (en) |
| DE (1) | DE3327705A1 (en) |
| DK (1) | DK361983A (en) |
| ES (1) | ES524815A0 (en) |
| FI (1) | FI73679C (en) |
| FR (1) | FR2531433B1 (en) |
| GB (1) | GB2125041B (en) |
| GR (1) | GR78923B (en) |
| HU (1) | HU187600B (en) |
| IL (1) | IL69450A (en) |
| IT (1) | IT1168961B (en) |
| MY (1) | MY8700166A (en) |
| NL (1) | NL8302776A (en) |
| NZ (1) | NZ205181A (en) |
| PH (1) | PH20385A (en) |
| PT (1) | PT77168B (en) |
| SE (1) | SE8304315L (en) |
| ZA (1) | ZA835850B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675322A (en) * | 1984-12-10 | 1987-06-23 | Eli Lilly And Company | 1-Substituted-6-n-propyl-8β-methylthio-methylergolines |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
| FR2589734B1 (en) * | 1985-11-13 | 1988-09-02 | Roussel Uclaf | USE OF ERGOLIN DERIVATIVES FOR OBTAINING A GERIATRIC MEDICINE |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
| DE3913756A1 (en) * | 1989-04-21 | 1990-10-25 | Schering Ag | 8 (BETA) SUBSTITUTED ERGOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE10212564B4 (en) * | 2002-03-12 | 2007-04-19 | Neurobiotec Gmbh | 1-Allyl ergot alkaloid derivatives and their use for the prophylaxis and treatment of migraine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE41533B1 (en) * | 1974-03-14 | 1980-01-30 | Sandoz Ltd | Thiomethyl ergolene derivatives |
| US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
| US3959288A (en) * | 1974-12-13 | 1976-05-25 | Eli Lilly And Company | 8-Oxymethylergolines and process therefor |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
-
1982
- 1982-08-09 CH CH4772/82A patent/CH649998A5/en not_active IP Right Cessation
-
1983
- 1983-08-01 DE DE19833327705 patent/DE3327705A1/en not_active Withdrawn
- 1983-08-02 FI FI832789A patent/FI73679C/en not_active IP Right Cessation
- 1983-08-04 FR FR8313018A patent/FR2531433B1/en not_active Expired
- 1983-08-05 NL NL8302776A patent/NL8302776A/en not_active Application Discontinuation
- 1983-08-05 GB GB08321222A patent/GB2125041B/en not_active Expired
- 1983-08-05 BE BE1/10847A patent/BE897473A/en not_active IP Right Cessation
- 1983-08-08 SE SE8304315A patent/SE8304315L/en not_active Application Discontinuation
- 1983-08-08 AU AU17672/83A patent/AU563736B2/en not_active Expired - Fee Related
- 1983-08-08 GR GR72165A patent/GR78923B/el unknown
- 1983-08-08 JP JP58144843A patent/JPS5948480A/en active Pending
- 1983-08-08 CA CA000434064A patent/CA1215972A/en not_active Expired
- 1983-08-08 ES ES524815A patent/ES524815A0/en active Granted
- 1983-08-08 PT PT77168A patent/PT77168B/en unknown
- 1983-08-08 NZ NZ205181A patent/NZ205181A/en unknown
- 1983-08-08 HU HU832798A patent/HU187600B/en unknown
- 1983-08-08 AT AT0286383A patent/AT383125B/en not_active IP Right Cessation
- 1983-08-08 IL IL69450A patent/IL69450A/en unknown
- 1983-08-08 DK DK361983A patent/DK361983A/en unknown
- 1983-08-09 ZA ZA835850A patent/ZA835850B/en unknown
- 1983-08-09 PH PH29378A patent/PH20385A/en unknown
- 1983-08-09 IT IT22490/83A patent/IT1168961B/en active
-
1987
- 1987-12-30 MY MY166/87A patent/MY8700166A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT77168B (en) | 1986-03-27 |
| AU1767283A (en) | 1984-02-16 |
| IL69450A (en) | 1986-10-31 |
| FI73679B (en) | 1987-07-31 |
| ZA835850B (en) | 1985-03-27 |
| GB2125041A (en) | 1984-02-29 |
| IT1168961B (en) | 1987-05-20 |
| FR2531433B1 (en) | 1985-10-18 |
| DK361983A (en) | 1984-02-10 |
| AU563736B2 (en) | 1987-07-23 |
| FI832789A0 (en) | 1983-08-02 |
| FI832789L (en) | 1984-02-10 |
| ATA286383A (en) | 1986-10-15 |
| DK361983D0 (en) | 1983-08-08 |
| HU187600B (en) | 1986-01-28 |
| GR78923B (en) | 1984-10-02 |
| SE8304315D0 (en) | 1983-08-08 |
| MY8700166A (en) | 1987-12-31 |
| ES524815A0 (en) | 1985-02-01 |
| IT8322490A0 (en) | 1983-08-09 |
| IL69450A0 (en) | 1983-11-30 |
| JPS5948480A (en) | 1984-03-19 |
| DE3327705A1 (en) | 1984-02-09 |
| GB8321222D0 (en) | 1983-09-07 |
| PT77168A (en) | 1983-09-01 |
| AT383125B (en) | 1987-05-25 |
| GB2125041B (en) | 1986-04-23 |
| FR2531433A1 (en) | 1984-02-10 |
| PH20385A (en) | 1986-12-08 |
| CA1215972A (en) | 1986-12-30 |
| CH649998A5 (en) | 1985-06-28 |
| FI73679C (en) | 1987-11-09 |
| NZ205181A (en) | 1986-07-11 |
| BE897473A (en) | 1984-02-06 |
| SE8304315L (en) | 1984-02-10 |
| NL8302776A (en) | 1984-03-01 |
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