ES8502869A1 - Procedimiento para la estabilizacion de preparados farmaceuticos de prostaglandinas. - Google Patents
Procedimiento para la estabilizacion de preparados farmaceuticos de prostaglandinas.Info
- Publication number
- ES8502869A1 ES8502869A1 ES500225A ES500225A ES8502869A1 ES 8502869 A1 ES8502869 A1 ES 8502869A1 ES 500225 A ES500225 A ES 500225A ES 500225 A ES500225 A ES 500225A ES 8502869 A1 ES8502869 A1 ES 8502869A1
- Authority
- ES
- Spain
- Prior art keywords
- blood serum
- prostaglandins
- stabilizing
- stabilization
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 6
- 239000000126 substance Substances 0.000 title abstract 4
- 210000002966 serum Anatomy 0.000 title abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 2
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA ESTABILIZACION DE PREPATADOS FARMACEUTICOS DE PROSTAGLANDINAS.CONSISTE EN: A) SEPARAR LOS COMPONENTES DE ALTO PESO MOLECULAR DE SUERO SANGUINEO MEDIANTE REACCIONES USUALES DE PRECIPITACION DE PROTEINAS O MEDIANTE EL USO DE TAMICES MOLECULARES; B) RECUPERAR COMO SUSTANCIA ACTIVA, A PARTIR DE LA FRACCION RESTANTE DE BAIO PESO MOLECULAR, UNA FRACCION CON PESO MOLECULAR INFERIOR A 2.000, MEDIANTE LA UTILIZACION REPETIDA DE METODOS CROMATOGRAFICOS; Y C) MEZCLAR LA FRACCION RECUPERADA, COMO ELUATO DE LA CROMATOGRAFIA EN COLUMNA, CON EL PREPARADO ACUOSO DE UNA PROSTAGLANDINA, O BIEN, DESPUES DE LA ELIMINACION DEL AGUA DEL ELUATO POR METODOS USUALES, COMO CONCENTRACION POR EVAPORACION, CONCENTRACION EN EVAPORADOR ROTATORIO O LIOFILIZACION, SE MEZCLA, COMO SUSTANCIA ACTIVA SOLIDA, CON UNA PROSTAGLANDINA SOLIDA, EN PROPORCION 10:1 A 10:1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803010002 DE3010002A1 (de) | 1980-03-15 | 1980-03-15 | Prostaglandine enthaltende pharmazeutische zubereitung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502869A1 true ES8502869A1 (es) | 1985-02-01 |
| ES500225A0 ES500225A0 (es) | 1985-02-01 |
Family
ID=6097308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500225A Granted ES500225A0 (es) | 1980-03-15 | 1981-03-10 | Procedimiento para la estabilizacion de preparados farmaceuticos de prostaglandinas. |
| ES510484A Expired ES8303324A1 (es) | 1980-03-15 | 1982-03-16 | "procedimiento para preparar una sustancia activa adecuada para la estabilizacion de prostaglandinas y sus derivados". |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510484A Expired ES8303324A1 (es) | 1980-03-15 | 1982-03-16 | "procedimiento para preparar una sustancia activa adecuada para la estabilizacion de prostaglandinas y sus derivados". |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4333948A (es) |
| EP (1) | EP0036514B1 (es) |
| JP (1) | JPS56150018A (es) |
| AT (1) | ATE16809T1 (es) |
| AU (1) | AU545065B2 (es) |
| CA (1) | CA1164343A (es) |
| DE (2) | DE3010002A1 (es) |
| ES (2) | ES500225A0 (es) |
| ZA (1) | ZA811672B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2536019T3 (pl) | 2011-06-17 | 2018-06-29 | Diehl Ako Stiftung & Co. Kg | Sposób sterowania falownikiem |
| CN102832880B (zh) | 2011-06-17 | 2017-03-01 | 迪尔阿扣基金两合公司 | 控制转换器的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617510A1 (de) * | 1966-04-20 | 1971-03-11 | Wolfgang Dr Med Helmbold | Verfahren zur Gewinnung wachstums- und stoffwechselfoerdernder niedermolekularer Substanzen |
| FR1535488A (fr) * | 1966-04-20 | 1968-08-09 | Behringwerke Ag | Substance à bas poids moléculaire et son isolement à partir de fractions sanguines |
| US4113882A (en) * | 1974-10-21 | 1978-09-12 | Yamanouchi Pharmaceutical Co., Ltd. | Stabilized oral prostaglandin formulation and the process for the preparation thereof |
| ZA787353B (en) * | 1978-05-17 | 1980-08-27 | Wellcome Found | Pharmaceutical formulations |
| GB2021581B (en) * | 1978-05-17 | 1982-10-20 | Wellcome Found | Stabilisation of pgl derivatives |
| US4178454A (en) * | 1978-10-11 | 1979-12-11 | Toray Industries, Inc. | Stabilized prostaglandin E composition |
-
1980
- 1980-03-15 DE DE19803010002 patent/DE3010002A1/de not_active Withdrawn
-
1981
- 1981-03-03 DE DE8181101503T patent/DE3173084D1/de not_active Expired
- 1981-03-03 EP EP81101503A patent/EP0036514B1/de not_active Expired
- 1981-03-03 AT AT81101503T patent/ATE16809T1/de not_active IP Right Cessation
- 1981-03-10 ES ES500225A patent/ES500225A0/es active Granted
- 1981-03-13 AU AU68358/81A patent/AU545065B2/en not_active Ceased
- 1981-03-13 CA CA000373004A patent/CA1164343A/en not_active Expired
- 1981-03-13 US US06/243,443 patent/US4333948A/en not_active Expired - Fee Related
- 1981-03-13 JP JP3548081A patent/JPS56150018A/ja active Pending
- 1981-03-13 ZA ZA00811672A patent/ZA811672B/xx unknown
-
1982
- 1982-03-16 ES ES510484A patent/ES8303324A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3173084D1 (en) | 1986-01-16 |
| EP0036514A2 (de) | 1981-09-30 |
| ES510484A0 (es) | 1983-02-01 |
| CA1164343A (en) | 1984-03-27 |
| ES8303324A1 (es) | 1983-02-01 |
| DE3010002A1 (de) | 1981-10-01 |
| EP0036514B1 (de) | 1985-12-04 |
| ZA811672B (en) | 1982-03-31 |
| AU545065B2 (en) | 1985-06-27 |
| AU6835881A (en) | 1981-09-24 |
| US4333948A (en) | 1982-06-08 |
| ATE16809T1 (de) | 1985-12-15 |
| ES500225A0 (es) | 1985-02-01 |
| JPS56150018A (en) | 1981-11-20 |
| EP0036514A3 (en) | 1982-06-09 |
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