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ES8501750A1 - Un procedimiento para la preparacion de 4-aril-4-piperidincarbinoles. - Google Patents

Un procedimiento para la preparacion de 4-aril-4-piperidincarbinoles.

Info

Publication number
ES8501750A1
ES8501750A1 ES522120A ES522120A ES8501750A1 ES 8501750 A1 ES8501750 A1 ES 8501750A1 ES 522120 A ES522120 A ES 522120A ES 522120 A ES522120 A ES 522120A ES 8501750 A1 ES8501750 A1 ES 8501750A1
Authority
ES
Spain
Prior art keywords
piperidinecarbinols
aryl
antidepressants
cases
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522120A
Other languages
English (en)
Other versions
ES522120A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES8501750A1 publication Critical patent/ES8501750A1/es
Publication of ES522120A0 publication Critical patent/ES522120A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 4-ARIL-4-PIPERIDINCARBINOLES, DE FORMULA GENERAL (I).COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UN COMPUESTO DE FORMULA: RLI CON LA PIPERIDINONA DE FORMULA GENERAL (II) PARA OBTENER UN COMPUESTO DE FORMULA (III); SEGUNDA, SE DESHIDRATA EL COMPUESTO DE FORMULA (III) PARA OBTENER UNA MEZCLA DE OLEFINAS; TERCERA, SE LITIA LA MEZCLA DE OLEFINAS OBTENIDA CON N-BUTIL-LITIO Y DESPUES SE HACEN REACCIONAR OON UNA CETONA, PARA PRODUCIR EL OCTAAZABICICLOOCTANO; Y POR ULTIMO, SE REDUCE EL OCTAAZABICICLOOCTANO PARA OBTENER EL COMPUESTO DE FORMULA GENERAL (I).DE APLICACION COMO AGENTES ANTIDEPRESIVOS Y ANOREXICOS.
ES522120A 1982-05-07 1983-05-05 Un procedimiento para la preparacion de 4-aril-4-piperidincarbinoles. Granted ES522120A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37622982A 1982-05-07 1982-05-07
US06/468,040 US4485109A (en) 1982-05-07 1983-02-25 4-Aryl-4-piperidinecarbinols

Publications (2)

Publication Number Publication Date
ES8501750A1 true ES8501750A1 (es) 1984-12-01
ES522120A0 ES522120A0 (es) 1984-12-01

Family

ID=27007350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522120A Granted ES522120A0 (es) 1982-05-07 1983-05-05 Un procedimiento para la preparacion de 4-aril-4-piperidincarbinoles.

Country Status (17)

Country Link
US (1) US4485109A (es)
EP (1) EP0094018B1 (es)
AU (1) AU560166B2 (es)
CA (1) CA1252790A (es)
DE (1) DE3375915D1 (es)
DK (1) DK161699C (es)
ES (1) ES522120A0 (es)
FI (1) FI78685C (es)
GR (1) GR77502B (es)
HU (1) HU188278B (es)
IE (1) IE55994B1 (es)
IL (1) IL68586A0 (es)
NO (1) NO162817C (es)
NZ (1) NZ204150A (es)
PH (1) PH18380A (es)
PT (1) PT76657B (es)
SU (1) SU1187718A3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019650A (en) * 1988-03-28 1991-05-28 E. I. Du Pont De Nemours And Company 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5086063A (en) * 1988-03-28 1992-02-04 Du Pont Merck Pharmaceutical Company 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
CA1337418C (en) * 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
JPH03135978A (ja) * 1989-08-08 1991-06-10 Merck Sharp & Dohme Ltd 置換ピリジン、その製法、処方並びに痴呆症における使用法
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
WO2002046156A2 (en) * 2000-12-06 2002-06-13 Sepracor, Inc. 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
AU2002337863B2 (en) * 2001-10-16 2007-10-11 Endo Pharmaceuticals Inc. Carbinols for the treatment of neuropathic dysfunction
US7560562B2 (en) * 2002-11-01 2009-07-14 Neurosearch A/S Piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
MX2007004216A (es) * 2004-10-13 2007-10-10 Neurosearch Sweden Ab Proceso para la sintesis de 4-(3-sulfonil)-piperidinas.
KR101319235B1 (ko) * 2004-10-13 2013-10-16 아이백스 인터내셔널 게엠베하 4-(3-메탄설폰일페닐)-1-ｎ-프로필-피페리딘의 합성 공정
CA2856749A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
US20130267552A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL88063C (es) * 1950-12-05
FR1049588A (fr) * 1950-12-05 1953-12-30 Schering Corp Procédé ?? préparation de pipéridines substituées
US2832786A (en) * 1956-02-27 1958-04-29 Wm S Merrell Co Phosphoramides
AT214445B (de) * 1957-08-14 1961-04-10 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen, substituierten 1-(β-Oxyäthyl)-4-phenylpiperidinen
GB841120A (en) * 1958-02-12 1960-07-13 J F Macfarlan & Co Ltd Improvements in or relating to piperidine compounds
GB888657A (en) * 1958-07-14 1962-01-31 J F Macfarlan & Co Ltd Piperidine carbinols
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
US3108211A (en) * 1960-08-08 1963-10-22 Electro Sonic Ind Inc Activation of ferroelectric elements
GB1243991A (en) * 1968-06-10 1971-08-25 Ici Ltd Piperidine, morpholine and piperazine derivatives
US3824242A (en) * 1973-01-26 1974-07-16 Research Corp Synthesis of meperidine
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
DE2746574A1 (de) * 1976-10-18 1978-04-20 Searle & Co 1-(3,3,3-triarylpropyl)-4-phenyl- 4-piperidinmethanolaether sowie verfahren zu deren herstellung
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FR2408602A2 (fr) * 1977-11-15 1979-06-08 Synthelabo Nouveaux derives de piperidine et leur methode de preparation
US4228288A (en) * 1978-11-29 1980-10-14 Eli Lilly And Company Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates
US4284635A (en) * 1978-11-29 1981-08-18 Eli Lilly And Company Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines

Also Published As

Publication number Publication date
NO162817C (no) 1990-02-21
FI831567L (fi) 1983-11-08
DK161699B (da) 1991-08-05
FI831567A0 (fi) 1983-05-06
US4485109A (en) 1984-11-27
PT76657B (en) 1986-04-16
AU1431183A (en) 1983-11-10
NZ204150A (en) 1985-05-31
FI78685C (fi) 1989-09-11
GR77502B (es) 1984-09-24
AU560166B2 (en) 1987-04-02
PT76657A (en) 1983-06-01
EP0094018B1 (en) 1988-03-09
IE831040L (en) 1983-11-07
NO831588L (no) 1983-11-08
NO162817B (no) 1989-11-13
PH18380A (en) 1985-06-19
CA1252790A (en) 1989-04-18
DK205083D0 (da) 1983-05-06
EP0094018A2 (en) 1983-11-16
HU188278B (en) 1986-03-28
FI78685B (fi) 1989-05-31
IL68586A0 (en) 1983-09-30
DK205083A (da) 1983-11-08
DE3375915D1 (de) 1988-04-14
SU1187718A3 (ru) 1985-10-23
IE55994B1 (en) 1991-03-13
DK161699C (da) 1992-01-13
ES522120A0 (es) 1984-12-01
EP0094018A3 (en) 1985-11-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519