ES8407032A1 - Un procedimiento para preparar acido 2-(4-(2-tiazoliloxi)fenil) propionico. - Google Patents
Un procedimiento para preparar acido 2-(4-(2-tiazoliloxi)fenil) propionico.Info
- Publication number
- ES8407032A1 ES8407032A1 ES519778A ES519778A ES8407032A1 ES 8407032 A1 ES8407032 A1 ES 8407032A1 ES 519778 A ES519778 A ES 519778A ES 519778 A ES519778 A ES 519778A ES 8407032 A1 ES8407032 A1 ES 8407032A1
- Authority
- ES
- Spain
- Prior art keywords
- thiazolyloxy
- phenyl
- production
- propionic acid
- improved process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXZTWBVFHQLTBU-UHFFFAOYSA-N 2-[4-(1,3-thiazol-2-yloxy)phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1OC1=NC=CS1 RXZTWBVFHQLTBU-UHFFFAOYSA-N 0.000 title abstract 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- QPUCJXWUVCISEC-UHFFFAOYSA-N 2-[4-(1,3-thiazol-2-yloxy)phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1OC1=NC=CS1 QPUCJXWUVCISEC-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 benzhydryl ester Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR ACIDO 2-4-(2-TIAZOLILOXI) FENIL-PROPIONICO.COMPRENDE: HACER REACCIONAR UN COMPUESTO DE FORMULA (I) CON 1 A 3 EQUIVALENTES EN MOLES DE BROMURO DE METILO EN DIMETILFORMAMIDA A UNA TEMPERATURA DE C5 A 5JC, EN PRESENCIA DE 1 A 3 EQUIVALENTES EN MOLES DE HIDROXIDO DE POTASIO EN POLVO; E HIDROLIZAR UN COMPUESTO DE FORMULA (II) CON 2 A 6 EQUIVALENTES EN MOLES DE HIDROXIDO DE SODIO A UNA TEMPERATURA DE 0 A 70JC EN METANOL, ETANOL O ISOPROPANOL, PARA OBTENER ACIDO 2-4-(2-TIAZOLILOXI)FENIL-PROPIONICO, DONDE R ES ISOPROPILO, SEC-BUTILO O BENZHIDRILO.TIENE APLICACION FARMACOÑOGICA COMO ANTI-INFLAMATORIOY ANALGESICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57031428A JPS58148870A (ja) | 1982-02-26 | 1982-02-26 | ２−〔４−（２−チアゾリルオキシ）フエニル〕プロピオン酸の工業的製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519778A0 ES519778A0 (es) | 1984-08-16 |
| ES8407032A1 true ES8407032A1 (es) | 1984-08-16 |
Family
ID=12330965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519778A Expired ES8407032A1 (es) | 1982-02-26 | 1983-02-14 | Un procedimiento para preparar acido 2-(4-(2-tiazoliloxi)fenil) propionico. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0088008B1 (es) |
| JP (1) | JPS58148870A (es) |
| KR (1) | KR840003622A (es) |
| AT (1) | ATE25380T1 (es) |
| CA (1) | CA1188699A (es) |
| DK (1) | DK95283A (es) |
| ES (1) | ES8407032A1 (es) |
| HU (1) | HU187863B (es) |
| PH (1) | PH18619A (es) |
| ZA (1) | ZA83639B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888348A (en) * | 1986-09-04 | 1989-12-19 | Ciba-Geigy Corporation | Substituted thioureas, isothioureas and carbodiimides |
| KR970042541A (ko) * | 1995-12-11 | 1997-07-24 | 김준웅 | 알킬 페닐프로피오네트 유도체-14c의 제조방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1051906A (en) * | 1973-10-24 | 1979-04-03 | Shionogi And Co. | Thiazole derivatives and production thereof |
-
1982
- 1982-02-26 JP JP57031428A patent/JPS58148870A/ja active Pending
-
1983
- 1983-01-31 ZA ZA83639A patent/ZA83639B/xx unknown
- 1983-02-01 CA CA000420722A patent/CA1188699A/en not_active Expired
- 1983-02-14 ES ES519778A patent/ES8407032A1/es not_active Expired
- 1983-02-17 PH PH28529A patent/PH18619A/en unknown
- 1983-02-18 AT AT83400349T patent/ATE25380T1/de active
- 1983-02-18 EP EP83400349A patent/EP0088008B1/en not_active Expired
- 1983-02-25 KR KR1019830000767A patent/KR840003622A/ko not_active Withdrawn
- 1983-02-25 DK DK95283A patent/DK95283A/da not_active Application Discontinuation
- 1983-02-25 HU HU83657A patent/HU187863B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1188699A (en) | 1985-06-11 |
| ATE25380T1 (de) | 1987-02-15 |
| JPS58148870A (ja) | 1983-09-05 |
| HU187863B (en) | 1986-02-28 |
| ES519778A0 (es) | 1984-08-16 |
| KR840003622A (ko) | 1984-09-15 |
| EP0088008B1 (en) | 1987-02-04 |
| ZA83639B (en) | 1983-10-26 |
| DK95283A (da) | 1983-08-27 |
| PH18619A (en) | 1985-08-21 |
| DK95283D0 (da) | 1983-02-25 |
| EP0088008A1 (en) | 1983-09-07 |
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