[go: up one dir, main page]

ES8207180A1 - Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 . - Google Patents

Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 .

Info

Publication number
ES8207180A1
ES8207180A1 ES507705A ES507705A ES8207180A1 ES 8207180 A1 ES8207180 A1 ES 8207180A1 ES 507705 A ES507705 A ES 507705A ES 507705 A ES507705 A ES 507705A ES 8207180 A1 ES8207180 A1 ES 8207180A1
Authority
ES
Spain
Prior art keywords
radical
preparation
hydrogen atom
lower alkyl
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507705A
Other languages
English (en)
Other versions
ES507705A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8207180A1 publication Critical patent/ES8207180A1/es
Publication of ES507705A0 publication Critical patent/ES507705A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDRO-5,6,7A-4H-TIENO 3,2-C) PIRIDINONA-2, ASI COMO DE SUS SALES DE ADICION CON ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (5), EN LA QUE R ES HIDROGENO O UN RADICAL FENILO, R ES HIDROGENO O ALQUILO INFERIOR Y N VALE DE 0 A 4. CONSISTE EN LA REACCION DE OSIDACION DE UN DERIVADO BORONICO DE FORMULA (II).EN LA QUE R'''' ES HIDROGENO O ALQUILO INFERIOR Y R, R'' Y N TINENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA HIDROLISIS DEL PRODUCTO OBTENIDO. LA REACCION DE OXIDACION SE LLEVA A CABO CON AGUA OXIGENADA EN UN SISOLVENTE INERTE, EVITANDO LA ELEVACION DE TEMPERATURA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIAGREGACION DE PLAQUETAS Y ANTITROMBOTICAS.
ES507705A 1980-11-28 1981-11-16 Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 . Granted ES507705A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8025274A FR2495156A1 (fr) 1980-11-28 1980-11-28 Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
ES8207180A1 true ES8207180A1 (es) 1982-09-01
ES507705A0 ES507705A0 (es) 1982-09-01

Family

ID=9248448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507705A Granted ES507705A0 (es) 1980-11-28 1981-11-16 Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 .

Country Status (36)

Country Link
US (1) US4515951A (es)
EP (1) EP0054442B1 (es)
JP (1) JPS57120590A (es)
KR (1) KR870000824B1 (es)
AR (1) AR230285A1 (es)
AT (1) ATE9160T1 (es)
AU (1) AU559923B2 (es)
BG (1) BG36348A3 (es)
CA (1) CA1182458A (es)
CS (1) CS224634B2 (es)
CY (1) CY1281A (es)
DD (1) DD201903A5 (es)
DE (1) DE3165788D1 (es)
DK (1) DK152132C (es)
ES (1) ES507705A0 (es)
FI (1) FI72520C (es)
FR (1) FR2495156A1 (es)
GR (1) GR78021B (es)
HK (1) HK61685A (es)
HU (1) HU183711B (es)
IE (1) IE51709B1 (es)
IL (1) IL64146A (es)
IN (1) IN155340B (es)
MA (1) MA19331A1 (es)
MY (1) MY8600008A (es)
NO (1) NO155665C (es)
NZ (1) NZ199021A (es)
OA (1) OA06951A (es)
PH (1) PH23776A (es)
PL (1) PL129598B1 (es)
PT (1) PT73988B (es)
RO (1) RO83129B (es)
SU (1) SU1110385A3 (es)
YU (1) YU42448B (es)
ZA (1) ZA817874B (es)
ZW (1) ZW27481A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FR2596392B1 (fr) * 1986-03-27 1988-08-05 Sanofi Sa Derives de l'acide a-(hydroxy-3 oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenylacetique, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
ES2018860B3 (es) * 1987-04-03 1991-05-16 Cl Pharma Nuevos derivados de 2 - acido acetico de tieniloxido, un procedimiento para su preparacion y el contenido en preparados farmaceuticos
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
JP2730319B2 (ja) * 1991-04-26 1998-03-25 日本ビクター株式会社 磁気ディスク装置
EP0785205B1 (en) * 1994-10-07 2002-04-17 Ube Industries, Ltd. 2-silyloxytetrahydrothienopyridine, salt thereof, and process for producing the same
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
BRPI9908319B8 (pt) * 1998-02-27 2021-07-06 Sankyo Co composto amino cíclico, composição farmacêutica, medicamento contendo um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo, e, uso de um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo.
MXPA03005770A (es) * 2000-12-25 2003-09-10 Sankyo Co Composiciones medicinales que contienen aspirina.
US7557101B2 (en) 2006-12-08 2009-07-07 Hoffman-La Roche Inc. 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN102241690B (zh) * 2010-05-13 2015-08-12 天津药物研究院 一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途
CN101948479B (zh) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 普拉格雷中间体及其制备方法
CN107011359A (zh) 2010-10-18 2017-08-04 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
CN108069981A (zh) * 2016-11-14 2018-05-25 天津药物研究院有限公司 5-取代-4,5,6,7-四氢噻吩并[3,2-c]吡啶-2(4H)-酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (es) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
FR2345150A2 (fr) * 1975-08-06 1977-10-21 Centre Etd Ind Pharma Nouveaux derives de la thienopyridine, et leur application
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2508459A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives de la tetrahydro-5,6,7,7a 4h thieno (3,2-c) pyridinone-2

Also Published As

Publication number Publication date
PH23776A (en) 1989-11-03
MA19331A1 (fr) 1982-07-01
CA1182458A (en) 1985-02-12
DE3165788D1 (en) 1984-10-04
PT73988B (fr) 1983-04-14
FR2495156A1 (fr) 1982-06-04
DK152132B (da) 1988-02-01
KR870000824B1 (ko) 1987-04-23
GR78021B (es) 1984-09-26
ATE9160T1 (de) 1984-09-15
CS224634B2 (en) 1984-01-16
YU279081A (en) 1983-06-30
HK61685A (en) 1985-08-23
FI72520B (fi) 1987-02-27
RO83129A (ro) 1984-02-21
AR230285A1 (es) 1984-03-01
BG36348A3 (en) 1984-10-15
PT73988A (fr) 1981-12-01
KR830007662A (ko) 1983-11-04
NO155665C (no) 1987-05-06
JPH0239517B2 (es) 1990-09-05
AU7742981A (en) 1982-06-03
ES507705A0 (es) 1982-09-01
SU1110385A3 (ru) 1984-08-23
HU183711B (en) 1984-05-28
OA06951A (fr) 1983-07-31
PL233979A1 (es) 1982-08-02
EP0054442B1 (fr) 1984-08-29
ZW27481A1 (en) 1982-02-17
PL129598B1 (en) 1984-05-31
DK520781A (da) 1982-05-29
FI72520C (fi) 1987-06-08
JPS57120590A (en) 1982-07-27
FR2495156B1 (es) 1983-08-05
IE812683L (en) 1982-05-28
US4515951A (en) 1985-05-07
NO155665B (no) 1987-01-26
EP0054442A1 (fr) 1982-06-23
ZA817874B (en) 1982-10-27
CY1281A (en) 1985-07-05
IE51709B1 (en) 1987-02-18
DD201903A5 (de) 1983-08-17
NZ199021A (en) 1984-03-30
YU42448B (en) 1988-08-31
RO83129B (ro) 1984-02-28
DK152132C (da) 1988-06-20
IL64146A0 (en) 1982-01-31
IL64146A (en) 1984-12-31
AU559923B2 (en) 1987-03-26
FI813730L (fi) 1982-05-29
IN155340B (es) 1985-01-19
MY8600008A (en) 1986-12-31
NO814055L (no) 1982-06-01

Similar Documents

Publication Publication Date Title
IL69049A0 (en) Thieno(3,2-c)pyridine derivatives,their preparation and pharmaceutical compositions containing them
ES8207180A1 (es) Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 .
IE820211L (en) Process for preparing 2-penem compounds
ES8302001A1 (es) Un procedimiento para la preparacion de nuevos derivados de cefalospirina.
SE8000205L (sv) Nya heterotricykliska derivat, sett for framstellning och anvendning derav sasom lekemedel samt farmaceutiska kompositioner innehallande dessa derivat
SE8102220L (sv) Anvendning av substituerade derivat av 4-fenyl-4-oxo-2-butensyra sasom lekemedel
IL86080A0 (en) Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same
ES8305372A1 (es) "procedimiento para la fabricacion de derivados de la tetrahidros -5,6,7,7a 4h-tieno (3,2-c)piridinona-2".
ES8205804A1 (es) Un procedimiento para la preparacio,n de nuevos derivados de denzopirano 2,3-d-v-triazol.
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
ES446325A1 (es) Procedimiento para preparar tieno-(3,2-c)-piridina y deriva-dos de la misma.
DE3373302D1 (en) Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them
SE8301785L (sv) Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning
ZA83771B (en) Substituted thienobenzodiazepinones and acid addition salts thereof,processes for the preparation thereof and pharmaceutical compositions containing these compounds
ZA807905B (en) 2-phenylamino-imidazolines-(2),compositions thereof and process for the preparation thereof
HUT50833A (en) Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
JPS55104266A (en) Novel pyridone derivative
JPS5436252A (en) Novel propano-anthracene derivatives and their preparation

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506