[go: up one dir, main page]

ES8306479A1 - Preparation of 2-amino-4- hydroxy-5-halo-substituted pyrimidine derivatives - Google Patents

Preparation of 2-amino-4- hydroxy-5-halo-substituted pyrimidine derivatives

Info

Publication number
ES8306479A1
ES8306479A1 ES82515190A ES515190A ES8306479A1 ES 8306479 A1 ES8306479 A1 ES 8306479A1 ES 82515190 A ES82515190 A ES 82515190A ES 515190 A ES515190 A ES 515190A ES 8306479 A1 ES8306479 A1 ES 8306479A1
Authority
ES
Spain
Prior art keywords
amino
preparation
halo
hydroxy
pyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES82515190A
Other languages
Spanish (es)
Other versions
ES515190A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES8306479A1 publication Critical patent/ES8306479A1/en
Publication of ES515190A0 publication Critical patent/ES515190A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-AMINO-4-HIIDROXI-5-HALOGENO-PIRIMIDINAS, DE FORMULA GENERAL (I), EN LA QUE R SIGNIFICA UN GRUPO ALQUILO CON 1 A 4 ATOMOS DE CARBONO O UN GRUPO FENILO; Y X REPRESENTA BROMO O YODO. CONSISTE EN HALOGENAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R TIENE EL SIGNIFICADO YA INDICADO, CON UNA SOLUCION ACIDA DE LOS COMPLEJOS HALOIDEOS DE INTERHALOGENOS. DE APLICACION EN PREPARADOS FARMACEUTICOS PARA COMBATIR LOS VIRUS Y TAMBIEN COMO ESTIMULANTE PARA LA FORMACION DE INTERFERONA.PROCEDURE FOR THE PREPARATION OF 2-AMINO-4-HIIDROXI-5-HALOGENO-PYRIMIDINES, OF GENERAL FORMULA (I), IN WHICH R MEANS AN ALKYL GROUP WITH 1 TO 4 CARBON ATOMS OR A PHENYL GROUP; AND X REPRESENTS BROMINE OR IODINE. IT CONSISTS OF HALOGENATING A COMPOUND OF GENERAL FORMULA (II), IN WHICH R HAS THE MEANING ALREADY INDICATED, WITH AN ACID SOLUTION OF THE HALOID COMPLEXES OF INTERHALOGENS. FOR APPLICATION IN PHARMACEUTICAL PREPARATIONS TO COMBAT VIRUSES AND ALSO AS A STIMULANT FOR THE FORMATION OF INTERFERON.

ES515190A 1981-08-28 1982-08-23 "PROCEDURE FOR OBTAINING 2-AMINO-4-HYDROXY-5-HALOGENOPYRIMIDINES". Granted ES515190A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU812482A HU187355B (en) 1981-08-28 1981-08-28 Process for preparing 2-amino-4-hydroxy-5-halo-substituted pyrimidine derivatives

Publications (2)

Publication Number Publication Date
ES8306479A1 true ES8306479A1 (en) 1983-06-01
ES515190A0 ES515190A0 (en) 1983-06-01

Family

ID=10959594

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515190A Granted ES515190A0 (en) 1981-08-28 1982-08-23 "PROCEDURE FOR OBTAINING 2-AMINO-4-HYDROXY-5-HALOGENOPYRIMIDINES".

Country Status (10)

Country Link
JP (1) JPS5874671A (en)
BE (1) BE894193A (en)
CH (1) CH648833A5 (en)
ES (1) ES515190A0 (en)
FI (1) FI822818A7 (en)
FR (1) FR2512021B1 (en)
GB (1) GB2107309B (en)
HU (1) HU187355B (en)
IT (1) IT1190971B (en)
SU (1) SU1132789A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
EP1144390A2 (en) * 1999-01-22 2001-10-17 Amgen Inc., Kinase inhibitors

Also Published As

Publication number Publication date
HU187355B (en) 1985-12-28
GB2107309B (en) 1985-05-30
FR2512021B1 (en) 1985-08-09
FI822818A0 (en) 1982-08-12
SU1132789A3 (en) 1984-12-30
IT1190971B (en) 1988-02-24
GB2107309A (en) 1983-04-27
ES515190A0 (en) 1983-06-01
JPS5874671A (en) 1983-05-06
IT8222986A1 (en) 1984-02-26
BE894193A (en) 1983-02-25
IT8222986A0 (en) 1982-08-26
FR2512021A1 (en) 1983-03-04
FI822818L (en) 1983-03-01
FI822818A7 (en) 1983-03-01
CH648833A5 (en) 1985-04-15

Similar Documents

Publication Publication Date Title
ES8207156A1 (en) PROCEDURE FOR THE PREPARATION OF NEW PYRIMIDINONES.
KR840004106A (en) Process for the preparation of quaternary 6,11-dihydro-dibenzo- [b, e] -thiepine-11-N-alkyl-norscopine ether
ES8604545A1 (en) Phenylacetic-acid derivatives, medicines containing these compounds and process for their preparation.
IT1207269B (en) DIPHENYLBUTYLPIPERAZINCARBOSSAMIDI, THEIR ADDITION SALTS WITH ACIDS AND PHARMACEUTICAL COMPOSITIONS; MANUFACTURING AND USE PROCEDURES.
KR830003478A (en) Method for preparing 6-N-propyl-8α-methoxymethyl or methyl mercaptomethyl ergoline derivative
ES521086A0 (en) PROCEDURE FOR THE PREPARATION OF IMIDAZOLILFENIL-TETRAHIDROPIRIDAZINAS.
ES8502703A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF TIENOPIRIMIDINE.
FR2365341A1 (en) L- (PHENYL-3 AMINO-2 PROPIONYLOXY) -2 ACETIC DERIVATIVES
ES8306479A1 (en) Preparation of 2-amino-4- hydroxy-5-halo-substituted pyrimidine derivatives
FR2355822A1 (en) INDOLACETIC ACID ESTERS DERIVATIVES. USEFUL AS ANTI-INFLAMMATORY AND ANALGESICS
DK113183D0 (en) CRONEETHER RELATIONSHIPS, THEIR MANUFACTURING AND USE
ES8304952A1 (en) Alkanolamine derivatives.
ES8402839A1 (en) PROCEDURE FOR THE OBTAINING OF NEW POLICE POLYAZHETERO CYCLICS.
IT1188176B (en) SALT OF CARNITINE PARTICULARLY SUITABLE FOR ORAL USE
NL193023B (en) Indolylalkanoic acid derivative, as well as anti-inflammatory drug.
SE7711146L (en) TIAPROSTAGLANDINER
ES8601175A1 (en) PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES BENZOHIDRILPIPERACINOS AND ITS ADDITIONAL SALTS ACIDES
SE8402361L (en) NEW ACYLAMINOPHENOLD DERIVATIVES
ES480593A1 (en) Furylmethyloxime ethers
GB932815A (en) Improvements in or relating to phenothiazine compounds
KR920016404A (en) Novel 2- (2,6-dichloroanilino) -phenylacetate and its preparation and use of topically applied pharmaceutical preparations
KR830002718A (en) Preparation of Pyrazole Derivatives
KR830003487A (en) Method for preparing benzodiazepines derivatives
SE8100122L (en) NEW 2-AMINOMETHYL-6-HALO-PHENOLES, PREPARATION OF THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE
ES8106501A1 (en) PROCEDURE FOR THE PREPARATION OF COMPOUNDS 1 (2H) -ISOQUINOLO-NICOS AND SIMILAR