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ES8306120A1 - Procedimiento para la obtencion de derivados de imidazol trisustituidos. - Google Patents

Procedimiento para la obtencion de derivados de imidazol trisustituidos.

Info

Publication number
ES8306120A1
ES8306120A1 ES514580A ES514580A ES8306120A1 ES 8306120 A1 ES8306120 A1 ES 8306120A1 ES 514580 A ES514580 A ES 514580A ES 514580 A ES514580 A ES 514580A ES 8306120 A1 ES8306120 A1 ES 8306120A1
Authority
ES
Spain
Prior art keywords
trisustituted
formula
procedure
obtaining
imidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514580A
Other languages
English (en)
Other versions
ES514580A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES514580A0 publication Critical patent/ES514580A0/es
Publication of ES8306120A1 publication Critical patent/ES8306120A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE IMIDAZOL TRISUSTITUIDOS Y DE SUS ISOMEROS Y SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R SON ARILO CARBOCICLICO O HETEROARILO; A ES UN RADICAL HIDROCARBONADO DIVALENTE; Y R PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE DESHIDROGENACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R , R , R Y A TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), O DE UNO DE SUS ISOMEROS. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A TEMPERATURAS ENTRE 100 C Y 300 C, EN PRESENCIA DE UN CATALIZADOR DE DESHIDROGENACION, TALES COMO PALADIO, PLATINO O SUS SALES SOPORTADOS SOBRE MATERIALES ADECUADOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANTIINFLAMATORIO.
ES514580A 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos. Expired ES8306120A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25

Publications (2)

Publication Number Publication Date
ES514580A0 ES514580A0 (es) 1983-05-16
ES8306120A1 true ES8306120A1 (es) 1983-05-16

Family

ID=4298165

Family Applications (8)

Application Number Title Priority Date Filing Date
ES504257A Granted ES504257A0 (es) 1980-07-25 1981-07-24 Procedimiento para la obtencion de derivados de imidazol trisustituidos
ES514581A Granted ES514581A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514583A Granted ES514583A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514580A Expired ES8306120A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514584A Expired ES8306124A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514582A Expired ES8306122A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514579A Expired ES8306119A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514585A Granted ES514585A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de oxazol trisustituidos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES504257A Granted ES504257A0 (es) 1980-07-25 1981-07-24 Procedimiento para la obtencion de derivados de imidazol trisustituidos
ES514581A Granted ES514581A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514583A Granted ES514583A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES514584A Expired ES8306124A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514582A Expired ES8306122A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514579A Expired ES8306119A1 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de imidazol trisustituidos.
ES514585A Granted ES514585A0 (es) 1980-07-25 1982-07-30 Procedimiento para la obtencion de derivados de oxazol trisustituidos.

Country Status (23)

Country Link
US (1) US4447431A (es)
EP (1) EP0045081B1 (es)
JP (1) JPS5756466A (es)
KR (13) KR850000883B1 (es)
AR (1) AR230269A1 (es)
AT (1) ATE17349T1 (es)
AU (2) AU7340481A (es)
CA (1) CA1175431A (es)
DD (2) DD201677A5 (es)
DE (1) DE3173434D1 (es)
DK (1) DK331881A (es)
ES (8) ES504257A0 (es)
FI (1) FI812326A7 (es)
GB (1) GB2080805B (es)
GR (1) GR75287B (es)
IE (1) IE52071B1 (es)
IL (1) IL63410A (es)
NO (1) NO812542L (es)
NZ (1) NZ197828A (es)
PL (8) PL237000A1 (es)
PT (1) PT73424B (es)
SU (8) SU1235454A3 (es)
ZA (1) ZA815078B (es)

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FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
JPH09505055A (ja) 1993-11-08 1997-05-20 スミスクライン・ビーチャム・コーポレイション サイトカイン媒介疾患治療用オキサゾール
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US5658903A (en) 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
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CN1548436A (zh) 1998-05-22 2004-11-24 ʷ��˿�������ȳ�ķ���޹�˾ 新的2-烷基取代咪唑化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
WO2000010563A1 (en) * 1998-08-20 2000-03-02 Smithkline Beecham Corporation Novel substituted triazole compounds
ATE258055T1 (de) 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
PL355912A1 (en) 1999-11-22 2004-05-31 Smithkline Beecham Plc. Novel compounds
EP1233950B1 (en) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
DE60015599T2 (de) 1999-11-23 2005-11-03 Smithkline Beecham Corp. 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
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ES2218391T3 (es) * 2000-03-06 2004-11-16 Smithkline Beecham Plc Derivados de imidazol como inhibidores de raf-cinasa.
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GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
US20040192689A1 (en) * 2001-09-05 2004-09-30 Dean David Kenneth Heterocycle-carboxamide derivatives as raf kinase inhibitors
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US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
NZ197828A (en) 1985-11-08
ES8306121A1 (es) 1983-05-16
KR850002750A (ko) 1985-05-15
ES8307245A1 (es) 1983-07-01
GB2080805A (en) 1982-02-10
JPS5756466A (en) 1982-04-05
ES8306123A1 (es) 1983-05-16
IL63410A0 (en) 1981-10-30
ES514579A0 (es) 1983-05-16
EP0045081A2 (de) 1982-02-03
PL237004A1 (en) 1983-02-28
KR850002744A (ko) 1985-05-15
ES514582A0 (es) 1983-05-16
PT73424A (en) 1981-08-01
KR850002752A (ko) 1985-05-15
ES8301472A1 (es) 1982-12-01
KR850002747A (ko) 1985-05-15
DD201677A5 (de) 1983-08-03
KR850000892B1 (ko) 1985-06-26
ES514584A0 (es) 1983-05-16
ES8306122A1 (es) 1983-05-16
ES514580A0 (es) 1983-05-16
EP0045081A3 (en) 1982-04-07
KR850002749A (ko) 1985-05-15
ES8306119A1 (es) 1983-05-16
SU1235454A3 (ru) 1986-05-30
SU1205763A3 (ru) 1986-01-15
FI812326L (fi) 1982-01-26
KR850000891B1 (ko) 1985-06-26
KR850000883B1 (ko) 1985-06-26
EP0045081B1 (de) 1986-01-08
SU1227112A3 (ru) 1986-04-23
KR830006230A (ko) 1983-09-20
GR75287B (es) 1984-07-13
PL232352A1 (es) 1982-12-20
AU7340481A (en) 1982-01-28
KR850000889B1 (ko) 1985-06-26
KR850000873B1 (ko) 1985-06-22
PT73424B (en) 1983-06-20
PL236997A1 (en) 1983-01-03
PL237000A1 (en) 1983-02-28
KR850000885B1 (ko) 1985-06-26
ES514583A0 (es) 1983-05-16
PL135822B1 (en) 1985-12-31
ES514581A0 (es) 1983-05-16
KR850000888B1 (ko) 1985-06-26
GB2080805B (en) 1984-03-07
KR850000886B1 (ko) 1985-06-26
KR850002746A (ko) 1985-05-15
ES8306124A1 (es) 1983-05-16
ZA815078B (en) 1982-07-28
IL63410A (en) 1986-04-29
KR850001064B1 (ko) 1985-07-25
DK331881A (da) 1982-01-26
KR850002753A (ko) 1985-05-15
AU5655586A (en) 1986-09-11
PL237005A1 (en) 1983-02-28
DD202554A5 (de) 1983-09-21
KR850000884B1 (ko) 1985-06-26
KR850002756A (ko) 1985-05-15
PL237003A1 (en) 1983-02-28
SU1205764A3 (ru) 1986-01-15
NO812542L (no) 1982-01-26
US4447431A (en) 1984-05-08
DE3173434D1 (en) 1986-02-20
IE811680L (en) 1982-01-25
KR850002755A (ko) 1985-05-15
SU1145928A3 (ru) 1985-03-15
KR850000890B1 (ko) 1985-06-26
KR850002745A (ko) 1985-05-15
ATE17349T1 (de) 1986-01-15
AR230269A1 (es) 1984-03-01
IE52071B1 (en) 1987-06-10
ES504257A0 (es) 1982-12-01
KR850002754A (ko) 1985-05-15
ES514585A0 (es) 1983-07-01
CA1175431A (en) 1984-10-02
SU1138023A3 (ru) 1985-01-30
PL237001A1 (en) 1983-02-28
FI812326A7 (fi) 1982-01-26
KR850000887B1 (ko) 1985-06-26
PL237002A1 (en) 1983-02-28
SU1152520A3 (en) 1985-04-23
KR850002748A (ko) 1985-05-15
SU1169534A3 (ru) 1985-07-23
KR850000911B1 (ko) 1985-06-27

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