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ES8305355A1 - Un procedimiento para la preparacion de derivados del indol. - Google Patents

Un procedimiento para la preparacion de derivados del indol.

Info

Publication number
ES8305355A1
ES8305355A1 ES513765A ES513765A ES8305355A1 ES 8305355 A1 ES8305355 A1 ES 8305355A1 ES 513765 A ES513765 A ES 513765A ES 513765 A ES513765 A ES 513765A ES 8305355 A1 ES8305355 A1 ES 8305355A1
Authority
ES
Spain
Prior art keywords
formula
indole
processes
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513765A
Other languages
English (en)
Other versions
ES513765A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES8305355A1 publication Critical patent/ES8305355A1/es
Publication of ES513765A0 publication Critical patent/ES513765A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL INDOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO C <-R; R ES HIDROGENO O METILO; Z ES 1-IMIDAZOLILO O 3-PIRIDILO; Y R E Y PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA CH=CY, EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, TAL COMO HIDROXIDO DE BENCILTRIMETILAMONIO O FLUORURO DE TETRABUTILAMONIO, A TEMPERATURAS ENTRE LA AMBIENTE Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA TROMBOSIS, ISQUEMIA CARDIACA, SINCOPES, JAQUECA, CANCER Y COMPLICACIONES VASCULARES DE LA DIABETES.
ES513765A 1981-07-07 1982-07-06 Un procedimiento para la preparacion de derivados del indol. Granted ES513765A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8120878 1981-07-07
GB8213864 1982-05-13

Publications (2)

Publication Number Publication Date
ES8305355A1 true ES8305355A1 (es) 1983-04-01
ES513765A0 ES513765A0 (es) 1983-04-01

Family

ID=26280039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513765A Granted ES513765A0 (es) 1981-07-07 1982-07-06 Un procedimiento para la preparacion de derivados del indol.

Country Status (17)

Country Link
US (1) US4451472A (es)
EP (1) EP0069513B1 (es)
AR (1) AR230056A1 (es)
AU (1) AU532640B2 (es)
CS (1) CS229934B2 (es)
DD (1) DD202714A5 (es)
DE (1) DE3275545D1 (es)
DK (1) DK297382A (es)
ES (1) ES513765A0 (es)
FI (1) FI822386A7 (es)
GB (1) GB2101992A (es)
GR (1) GR76214B (es)
IL (1) IL66223A0 (es)
NO (1) NO822360L (es)
PL (1) PL240814A1 (es)
PT (1) PT75191B (es)
YU (1) YU145482A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
AU5279390A (en) * 1989-03-31 1990-11-05 Kyoto Pharmaceutical Industries, Ltd. New imidazole derivatives, production thereof, and uses thereof as medicines
JPH03258779A (ja) * 1990-03-06 1991-11-19 Mitsui Toatsu Chem Inc イミダゾール誘導体及び該イミダゾール誘導体を有効成分とする抗痙攣剤
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
GB9310635D0 (en) * 1993-05-21 1993-07-07 Glaxo Group Ltd Chemical compounds
GB9319100D0 (en) * 1993-09-15 1993-11-03 Pfizer Ltd 3-(3-pyridinyl)h-indoles
GEP201706616B (en) 2011-07-29 2017-02-10 Karyopharm Therapeutics Inc Hydrazide containing nuclear transport modulators and usage thereof
WO2013170068A2 (en) 2012-05-09 2013-11-14 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
CA2915365C (en) 2013-06-21 2022-08-16 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
MA40254B1 (fr) 2014-08-15 2022-09-30 Karyopharm Therapeutics Inc Polymorphes du selinexor
MA43530A (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc Modulateurs de transport nucléaire et leurs utilisations
MA43529A (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc Modulateurs de transport nucléaire et leurs utilisations
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462440A (en) * 1965-12-03 1969-08-19 American Home Prod 1,4-bis(2-indol-3-ylethyl)piperidines
FR2272081A1 (en) * 1974-05-22 1975-12-19 Labaz Anti-inflammatory indolylpyridylketones prepn. - from 2-alkyl (or aryl) indole and pyridine carboxylic acid chlorides
DE2960547D1 (en) * 1978-02-24 1981-11-05 Pfizer Ltd 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
IT1162310B (it) * 1978-05-02 1987-03-25 Ono Pharmaceutical Co Derivati di imidazolo e procedimento per produrli
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
JPS5951943B2 (ja) * 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体
GB2045244B (en) * 1979-03-07 1983-01-26 Pfizer Ltd 3-1-(imidazolylalkyl) indoles
US4363912A (en) * 1980-12-15 1982-12-14 Pfizer Inc. Indole thromboxane synthetase inhibitors

Also Published As

Publication number Publication date
AR230056A1 (es) 1984-02-29
CS229934B2 (en) 1984-07-16
GB2101992A (en) 1983-01-26
DK297382A (da) 1983-01-08
NO822360L (no) 1983-01-10
FI822386L (fi) 1983-01-08
GR76214B (es) 1984-08-04
FI822386A0 (fi) 1982-07-05
EP0069513A2 (en) 1983-01-12
FI822386A7 (fi) 1983-01-08
PT75191A (en) 1982-08-01
DD202714A5 (de) 1983-09-28
US4451472A (en) 1984-05-29
YU145482A (en) 1985-03-20
IL66223A0 (en) 1982-11-30
PT75191B (en) 1985-10-04
EP0069513B1 (en) 1987-03-04
ES513765A0 (es) 1983-04-01
AU532640B2 (en) 1983-10-06
EP0069513A3 (en) 1984-03-21
DE3275545D1 (en) 1987-04-09
AU8563882A (en) 1983-02-03
PL240814A1 (en) 1983-10-10

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