ES8305351A1 - Procedimiento para la preparacion de derivados de isoquino- leina - Google Patents
Procedimiento para la preparacion de derivados de isoquino- leinaInfo
- Publication number
- ES8305351A1 ES8305351A1 ES506583A ES506583A ES8305351A1 ES 8305351 A1 ES8305351 A1 ES 8305351A1 ES 506583 A ES506583 A ES 506583A ES 506583 A ES506583 A ES 506583A ES 8305351 A1 ES8305351 A1 ES 8305351A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- isoquinoline derivatives
- processes
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ISOQUINOLEINA, DE FORMULA GENERAL (I), EN LA QUE M SIGNIFICA 1 O 2; N SIGNIFICA 1; R SIGNIFICA HIDROGENO, ALCOHILO CON 1 A 6 ATOMOS DE CARBONO, TIENILO, FENILO, TRIFLUORMETILO O UN HALOGENO; R SIGNIFICA HIDROGENO O ALCOHILO CON 1 A 6 ATOMOS DE CARBONO; Y R SIGNIFICA HIDROGENO, HALOGENO, HIDROXI O ALCOHILO CON 1 A 6 ATOMOS DE CARBONO, ASI COMO SUS SALES FISIOLOGICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN DONDE R , R Y M TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON UN COMPUESTO DE FORMULA (III), EN DONDE HAL SIGNIFICA HALOGENO, Y R TIENE EL SIGNIFICADO YA MENCIONADO. DE APLICACION EN FARMACOLOGIA POR SUS EFECTOS SOBRE EL SISTEMA NERVIOSO CENTRAL Y SOBRE EL SISTEMA CIRCULATORIO CARDIACO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803034001 DE3034001A1 (de) | 1980-09-10 | 1980-09-10 | Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8305351A1 true ES8305351A1 (es) | 1983-04-01 |
| ES506583A0 ES506583A0 (es) | 1983-04-01 |
Family
ID=6111554
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505191A Expired ES8206511A1 (es) | 1980-09-10 | 1981-09-04 | Procedimiento para la preparacion de derivados de isoquino- leina |
| ES506584A Expired ES8304563A1 (es) | 1980-09-10 | 1981-10-27 | Procedimiento para la preparacion de derivados de isoquino- leina |
| ES506583A Granted ES506583A0 (es) | 1980-09-10 | 1981-10-27 | Procedimiento para la preparacion de derivados de isoquino- leina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505191A Expired ES8206511A1 (es) | 1980-09-10 | 1981-09-04 | Procedimiento para la preparacion de derivados de isoquino- leina |
| ES506584A Expired ES8304563A1 (es) | 1980-09-10 | 1981-10-27 | Procedimiento para la preparacion de derivados de isoquino- leina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4590273A (es) |
| EP (1) | EP0047923B1 (es) |
| JP (1) | JPS5780372A (es) |
| KR (1) | KR830007622A (es) |
| AT (1) | ATE7389T1 (es) |
| AU (1) | AU541976B2 (es) |
| CA (1) | CA1168232A (es) |
| DE (2) | DE3034001A1 (es) |
| DK (1) | DK400681A (es) |
| ES (3) | ES8206511A1 (es) |
| FI (1) | FI71734C (es) |
| GR (1) | GR74978B (es) |
| HU (1) | HU187357B (es) |
| IE (1) | IE51551B1 (es) |
| IL (1) | IL63765A (es) |
| NO (1) | NO813066L (es) |
| NZ (1) | NZ198308A (es) |
| PH (1) | PH19431A (es) |
| PT (1) | PT73629B (es) |
| ZA (1) | ZA816237B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4656174A (en) * | 1982-07-24 | 1987-04-07 | Pfizer Inc. | Quinoline therapeutic agents |
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
| US4544657A (en) * | 1983-05-19 | 1985-10-01 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
| FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4843077A (en) * | 1987-06-09 | 1989-06-27 | Ortho Pharmaceutical Corporation | Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties |
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| US5332733A (en) * | 1990-11-24 | 1994-07-26 | Kali-Chemie Pharma Gmbh | Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them |
| US6008352A (en) * | 1997-04-03 | 1999-12-28 | Neurogen Corporation | 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands |
| US5972945A (en) * | 1997-06-13 | 1999-10-26 | Neurogen Corporation | 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands |
| US6313141B1 (en) | 1997-06-13 | 2001-11-06 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
| ATE404539T1 (de) * | 1997-10-02 | 2008-08-15 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
| US6040448A (en) | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| HU226859B1 (en) * | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
| US6613901B2 (en) | 2000-03-08 | 2003-09-02 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
| CA2657702A1 (en) * | 2006-07-03 | 2008-01-10 | Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg | Quinazolines and related heterocyclic comp0unds, and their therapeutic use |
| EA026115B1 (ru) * | 2010-12-17 | 2017-03-31 | Ф. Хоффманн-Ля Рош Аг | Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение |
| BR112019019555A2 (pt) | 2017-03-30 | 2020-04-22 | Hoffmann La Roche | composto de fórmula i, composição farmacêutica, método de inibição de hpk1, método para melhorar uma resposta imune, método para tratar um distúrbio e uso do composto |
| CN112601584A (zh) | 2018-07-24 | 2021-04-02 | 豪夫迈·罗氏有限公司 | 异喹啉化合物及其用途 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517005A (en) * | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
| GB1244501A (en) * | 1968-03-09 | 1971-09-02 | Aspro Nicholas Ltd | Heterocyclic amines |
| DE2030675A1 (en) * | 1969-06-23 | 1971-02-11 | Arthur D Little, Inc , Cambridge, Mass (V St A) | 3-amino-4-phenyl-isoquinoline derivs |
| US3932412A (en) * | 1970-12-07 | 1976-01-13 | Sandoz, Inc. | 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates |
| AT342057B (de) * | 1974-04-25 | 1978-03-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen |
| DE2503961C3 (de) * | 1975-01-31 | 1980-02-28 | Dr. Karl Thomae Gmbh, 7950 Biberach | Isochinoline |
| DE2420012C3 (de) * | 1974-04-25 | 1980-01-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | Isochinoline |
| DE2811312A1 (de) * | 1978-03-16 | 1979-09-27 | Hoechst Ag | Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
| DE2818403A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
-
1980
- 1980-09-10 DE DE19803034001 patent/DE3034001A1/de not_active Withdrawn
-
1981
- 1981-09-03 DE DE8181106884T patent/DE3163510D1/de not_active Expired
- 1981-09-03 EP EP81106884A patent/EP0047923B1/de not_active Expired
- 1981-09-03 AT AT81106884T patent/ATE7389T1/de not_active IP Right Cessation
- 1981-09-04 ES ES505191A patent/ES8206511A1/es not_active Expired
- 1981-09-07 JP JP56139850A patent/JPS5780372A/ja active Pending
- 1981-09-08 PT PT73629A patent/PT73629B/pt unknown
- 1981-09-08 NZ NZ198308A patent/NZ198308A/en unknown
- 1981-09-08 GR GR65975A patent/GR74978B/el unknown
- 1981-09-08 KR KR1019810003356A patent/KR830007622A/ko not_active Ceased
- 1981-09-08 FI FI812783A patent/FI71734C/fi not_active IP Right Cessation
- 1981-09-08 IL IL63765A patent/IL63765A/xx unknown
- 1981-09-09 CA CA000385547A patent/CA1168232A/en not_active Expired
- 1981-09-09 IE IE2094/81A patent/IE51551B1/en unknown
- 1981-09-09 HU HU812595A patent/HU187357B/hu unknown
- 1981-09-09 AU AU75091/81A patent/AU541976B2/en not_active Ceased
- 1981-09-09 NO NO813066A patent/NO813066L/no unknown
- 1981-09-09 DK DK400681A patent/DK400681A/da not_active Application Discontinuation
- 1981-09-09 ZA ZA816237A patent/ZA816237B/xx unknown
- 1981-10-27 ES ES506584A patent/ES8304563A1/es not_active Expired
- 1981-10-27 ES ES506583A patent/ES506583A0/es active Granted
-
1984
- 1984-02-24 PH PH30299A patent/PH19431A/en unknown
- 1984-03-28 US US06/594,366 patent/US4590273A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL63765A0 (en) | 1981-12-31 |
| ES506584A0 (es) | 1983-03-01 |
| ATE7389T1 (de) | 1984-05-15 |
| DK400681A (da) | 1982-03-11 |
| FI71734C (fi) | 1987-02-09 |
| EP0047923A1 (de) | 1982-03-24 |
| IL63765A (en) | 1985-05-31 |
| IE51551B1 (en) | 1987-01-07 |
| PT73629B (de) | 1983-04-29 |
| NO813066L (no) | 1982-03-11 |
| PT73629A (de) | 1981-10-01 |
| DE3163510D1 (en) | 1984-06-14 |
| FI71734B (fi) | 1986-10-31 |
| FI812783L (fi) | 1982-03-11 |
| ZA816237B (en) | 1982-08-25 |
| DE3034001A1 (de) | 1982-04-22 |
| HU187357B (en) | 1985-12-28 |
| CA1168232A (en) | 1984-05-29 |
| GR74978B (es) | 1984-07-12 |
| EP0047923B1 (de) | 1984-05-09 |
| NZ198308A (en) | 1984-03-30 |
| ES505191A0 (es) | 1982-08-16 |
| ES8206511A1 (es) | 1982-08-16 |
| ES506583A0 (es) | 1983-04-01 |
| US4590273A (en) | 1986-05-20 |
| PH19431A (en) | 1986-04-15 |
| AU7509181A (en) | 1982-03-18 |
| AU541976B2 (en) | 1985-01-31 |
| IE812094L (en) | 1982-03-10 |
| JPS5780372A (en) | 1982-05-19 |
| ES8304563A1 (es) | 1983-03-01 |
| KR830007622A (ko) | 1983-11-04 |
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