[go: up one dir, main page]

ES8302682A1 - Un metodo de preparar derivados de fenil-piperazina - Google Patents

Un metodo de preparar derivados de fenil-piperazina

Info

Publication number
ES8302682A1
ES8302682A1 ES505372A ES505372A ES8302682A1 ES 8302682 A1 ES8302682 A1 ES 8302682A1 ES 505372 A ES505372 A ES 505372A ES 505372 A ES505372 A ES 505372A ES 8302682 A1 ES8302682 A1 ES 8302682A1
Authority
ES
Spain
Prior art keywords
group
phenyl
piperazine derivatives
punitive
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505372A
Other languages
English (en)
Other versions
ES505372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of ES8302682A1 publication Critical patent/ES8302682A1/es
Publication of ES505372A0 publication Critical patent/ES505372A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO PARA PREPARAR DERIVADOS DE FENIL-PIPERAZINA. SE HACE REACCIONAR EL COMPUESTO (I) CON EL CL<024>A<024>CO<024>NH<024>CO<024>R EN UN DISOLVENTE INERTE TAL COMO ETANOL O ACETONITRILO A UNA TEMPERATURA COMPRENDIDA ENTRE 20<025>C Y EL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO, EN PRESENCIA DE UN CAPTADOR DE ACIDO. SE OBTIENE EL COMPUESTO (II) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES: R ES UN GRUPO TRIFLUOROMETILO O UN ATOMO DE HALOGENO. R ES UN GRUPO ALCOHILO O UN GRUPO ALCOXI, UN GRUPO CICLOALCOXILO TRIFLUOROMETILO, VINILO, NITRILO, FENILO, FENILO SUBSTITUIDO, UN GRUPO TIENILO, UN GRUPO PIRIDILO, UN GRUPO PIRIMIDILO U OTROS. TRATAMIENTO DEL COMPORTAMIENTO INTRAPUNITIVO Y EXTRAPUNITIVO.
ES505372A 1980-09-12 1981-09-10 Un metodo de preparar derivados de fenil-piperazina Granted ES505372A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8005132A NL8005132A (nl) 1980-09-12 1980-09-12 Fenylpiperazinederivaten met antiagressieve werking.

Publications (2)

Publication Number Publication Date
ES8302682A1 true ES8302682A1 (es) 1982-12-01
ES505372A0 ES505372A0 (es) 1982-12-01

Family

ID=19835869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505372A Granted ES505372A0 (es) 1980-09-12 1981-09-10 Un metodo de preparar derivados de fenil-piperazina

Country Status (17)

Country Link
EP (1) EP0048044A1 (es)
JP (1) JPS5781477A (es)
AU (1) AU7502881A (es)
CA (1) CA1158647A (es)
CS (1) CS228531B2 (es)
DD (1) DD202288A5 (es)
DK (1) DK399981A (es)
ES (1) ES505372A0 (es)
FI (1) FI812807L (es)
GR (1) GR75818B (es)
HU (1) HU184965B (es)
IL (1) IL63783A0 (es)
NL (1) NL8005132A (es)
PH (1) PH17399A (es)
PL (1) PL232966A1 (es)
YU (1) YU217481A (es)
ZA (1) ZA816255B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK101683A (da) * 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
US4477646A (en) * 1983-08-24 1984-10-16 The Dow Chemical Company Piperazinoethyl ureas
JP2641280B2 (ja) * 1988-12-29 1997-08-13 日本ペイント株式会社 新規な環状ウレア誘導体
JPH0735363B2 (ja) * 1990-07-03 1995-04-19 日本ペイント株式会社 不飽和カルバミン酸エステル類の製法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3824530A (en) * 1972-12-05 1974-07-16 Amp Inc Installation of electrical connectors on wires intermediate the ends thereof

Also Published As

Publication number Publication date
CS228531B2 (en) 1984-05-14
DD202288A5 (de) 1983-09-07
CA1158647A (en) 1983-12-13
PL232966A1 (es) 1982-10-25
DK399981A (da) 1982-03-13
AU7502881A (en) 1982-03-18
ZA816255B (en) 1983-04-27
NL8005132A (nl) 1982-04-01
GR75818B (es) 1984-08-02
ES505372A0 (es) 1982-12-01
PH17399A (en) 1984-08-08
IL63783A0 (en) 1981-12-31
FI812807A7 (fi) 1982-03-13
FI812807L (fi) 1982-03-13
HU184965B (en) 1984-11-28
YU217481A (en) 1983-09-30
JPS5781477A (en) 1982-05-21
EP0048044A1 (en) 1982-03-24

Similar Documents

Publication Publication Date Title
ES8604226A1 (es) Procedimiento para preparar (2-oxo-1, 2, 3, 5-tetrahidroimidazo (2, 1-b) quinazolinil) oxialquilamidas
ES477008A1 (es) Procedimiento para la preparacion de difenileteres.
AR241244A1 (es) Metodo para la preparacion de carboxilatos y dicarboxilatos de piridina sustituidos.
ES8503669A1 (es) Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
AR241784A1 (es) Procedimiento para la preparacion de nuevos 2-(guanidino n-sustituido)-4-heteroaril-tiazoles.
ES8801241A1 (es) Un procedimiento para preparar laudanos
ES480053A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
ES2069281T3 (es) Derivado de fenantreno.
ES414159A1 (es) Procedimiento para la preparacion de nuevos derivados de 2-fenilamino-imidazolina-(2).
ES8308326A1 (es) Procedimiento para la preparacion de amidobenzamidas.
ES8302682A1 (es) Un metodo de preparar derivados de fenil-piperazina
ES293991A1 (es) Un procedimiento para fabricar derivados de piridina
ES469353A1 (es) Un procedimiento para la preparacion de compuestos derivadosde bencimidazol
ES8600205A1 (es) Procedimiento de preparacion de nuevos derivados dialquilaminoalcoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias
GB1096006A (en) Substituted biurets
IL68228A0 (en) Thiomethylpyridine derivatives,process for the production thereof and medicaments containing them
ES465537A1 (es) Un procedimiento para la preparacion de un alcohol-x-(3,4- dimetoxifenetilaminometil)-2-alcoxibencilico racemico u op- ticamente activo
ES8200884A1 (es) Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos
ES470757A1 (es) Un procedimiento para la preparacion de nuevos compuestos de acidos 2-alquil(inferior)2 o 3-cefem-4-carboxilicos-7- sustituidos
ES390163A1 (es) Procedimiento para la preparacion de amino-derivados de los acidos pirazolo (3,4-b) piridina-5-carboxilicos.
ES468127A1 (es) Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina
ES8600297A1 (es) Procedimiento para preparar derivados de imidazol.
ES8502992A1 (es) Procedimiento para la preparacion de un (tio)-eter de 2-metil-liserg-8-ilo
ES455907A1 (es) Un procedimiento para la preparacion de derivados de benza- mida.
ES8106156A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolotriazona