ES8300725A1 - "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". - Google Patents
"procedimiento para la preparacion de 3,1-benzoxazin-2-onas".Info
- Publication number
- ES8300725A1 ES8300725A1 ES508653A ES508653A ES8300725A1 ES 8300725 A1 ES8300725 A1 ES 8300725A1 ES 508653 A ES508653 A ES 508653A ES 508653 A ES508653 A ES 508653A ES 8300725 A1 ES8300725 A1 ES 8300725A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen
- alkyl
- methyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GZOJTRITAZODJV-UHFFFAOYSA-N 3,1-benzoxazin-2-one Chemical class C1=CC=CC2=COC(=O)N=C21 GZOJTRITAZODJV-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 4
- -1 hydroxy, methyl Chemical group 0.000 abstract 4
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003195 tocolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 3,1-BENZOXAZIN-2-ONAS Y DE SUS SALES DE ADICION DE ACIDOS, EN FORMA DE RACEMATOS, PARES DE ANTIPODAS DIASTEREOISOMEROS Y ENANTIOMEROS, DE FORMULA (I), EN LA QUE R Y R SON HIDROGENO O ALCOHILO C <003> ; R Y R SON HIDROGENO O METILO; R , R Y R PUEDEN SER VARIOS RADICALES Y N VALE DE 1 A 3. CONSISTE EN LA REACCION DE ALCOHILACION REDUCTIVA DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE N Y R <024>R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y R, R , R Y R P PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO UTILIZANDO HIDRUROS COMPLEJOS O MEDIANTE HIDROGENACION CATALITICA EN DISOLVENTES ORGANICOS INERTES. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR Y TOCOLITICO Y COMO BRONCOLITICOS, VASODILATADORES Y AGENTES CARDIACOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803026534 DE3026534A1 (de) | 1980-07-12 | 1980-07-12 | 3,1-benzoxazin-2-one, ihre herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8300725A1 true ES8300725A1 (es) | 1982-11-01 |
| ES508653A0 ES508653A0 (es) | 1982-11-01 |
Family
ID=6107085
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES503837A Expired ES8205402A1 (es) | 1980-07-12 | 1981-07-10 | Procedimiento para la preparacion de 3,1-benzoxazin-2-onas |
| ES508655A Expired ES8300727A1 (es) | 1980-07-12 | 1982-01-12 | "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". |
| ES508653A Granted ES508653A0 (es) | 1980-07-12 | 1982-01-12 | "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". |
| ES508654A Granted ES508654A0 (es) | 1980-07-12 | 1982-01-12 | "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES503837A Expired ES8205402A1 (es) | 1980-07-12 | 1981-07-10 | Procedimiento para la preparacion de 3,1-benzoxazin-2-onas |
| ES508655A Expired ES8300727A1 (es) | 1980-07-12 | 1982-01-12 | "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508654A Granted ES508654A0 (es) | 1980-07-12 | 1982-01-12 | "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4341778A (es) |
| EP (1) | EP0043940B1 (es) |
| JP (1) | JPS5748975A (es) |
| KR (1) | KR850000755B1 (es) |
| AT (1) | ATE9336T1 (es) |
| AU (1) | AU540916B2 (es) |
| CA (1) | CA1165317A (es) |
| DD (1) | DD202018A5 (es) |
| DE (2) | DE3026534A1 (es) |
| DK (1) | DK149851C (es) |
| ES (4) | ES8205402A1 (es) |
| FI (1) | FI74703C (es) |
| GB (1) | GB2080296B (es) |
| GR (1) | GR74333B (es) |
| HK (1) | HK98286A (es) |
| HU (1) | HU183515B (es) |
| IE (1) | IE52508B1 (es) |
| IL (1) | IL63285A (es) |
| NO (1) | NO158578C (es) |
| NZ (1) | NZ197678A (es) |
| PH (1) | PH17425A (es) |
| PT (1) | PT73338B (es) |
| SG (1) | SG77686G (es) |
| YU (1) | YU170181A (es) |
| ZA (1) | ZA814687B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446319A (en) * | 1981-04-28 | 1984-05-01 | Takeda Chemical Industries, Ltd. | Aminocyclitols and their production |
| JPS62238288A (ja) * | 1986-04-04 | 1987-10-19 | Nippon Tokushu Noyaku Seizo Kk | 環状カルバメ−ト及び農園芸用殺菌剤 |
| FR2636065B1 (fr) * | 1988-09-08 | 1993-05-07 | Fabre Sa Pierre | Nouveaux derives de dihydro-2,3 arylacoylaminoalcoyl-3 4h-benzoxazine-1,3 ones-4, leur preparation et leur application en tant que medicaments utiles en therapeutique |
| JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| FR2680172B1 (fr) * | 1991-08-05 | 1993-11-19 | Fabre Medicament Pierre | Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique. |
| WO1996022775A1 (en) * | 1995-01-24 | 1996-08-01 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5874430A (en) * | 1996-10-02 | 1999-02-23 | Dupont Pharmaceuticals Company | 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same |
| DE102004003428A1 (de) | 2004-01-23 | 2005-08-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel |
| JPWO2006077821A1 (ja) * | 2005-01-19 | 2008-06-19 | 大日本住友製薬株式会社 | アルドステロン受容体調節剤としての芳香族スルホン化合物 |
| DE102005008921A1 (de) * | 2005-02-24 | 2006-08-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von Atemwegserkrankungen |
| US7423146B2 (en) * | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| WO2008023001A1 (en) * | 2006-08-22 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation containing enantiomerically pure beta-agonists |
| UY30552A1 (es) * | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones |
| PE20080610A1 (es) * | 2006-08-22 | 2008-07-15 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos |
| PE20080425A1 (es) * | 2006-08-22 | 2008-06-16 | Boehringer Ingelheim Int | Formulacion aerosol para la inhalacion de beta-agonistas |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3526621A (en) * | 1966-08-03 | 1970-09-01 | Farmaceutical Italia Soc | Substituted 3,1-benzoxazin-2-one |
| DE2609645A1 (de) * | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
| US4163053A (en) * | 1977-12-27 | 1979-07-31 | Schering Corporation | Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides |
| FI791727A7 (fi) * | 1978-06-05 | 1981-01-01 | Ciba Geigy Ag | Menetelmä N-alkyloitujen aminoalkoholien valmistamiseksi. |
| DE2833140A1 (de) * | 1978-07-28 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue n-substituierte heterocyclen |
-
1980
- 1980-07-12 DE DE19803026534 patent/DE3026534A1/de not_active Withdrawn
-
1981
- 1981-06-22 AT AT81104787T patent/ATE9336T1/de not_active IP Right Cessation
- 1981-06-22 EP EP81104787A patent/EP0043940B1/de not_active Expired
- 1981-06-22 DE DE8181104787T patent/DE3166003D1/de not_active Expired
- 1981-07-06 US US06/280,349 patent/US4341778A/en not_active Expired - Fee Related
- 1981-07-07 PH PH25873A patent/PH17425A/en unknown
- 1981-07-09 PT PT73338A patent/PT73338B/pt unknown
- 1981-07-09 YU YU01701/81A patent/YU170181A/xx unknown
- 1981-07-10 NZ NZ197678A patent/NZ197678A/en unknown
- 1981-07-10 CA CA000381559A patent/CA1165317A/en not_active Expired
- 1981-07-10 ZA ZA814687A patent/ZA814687B/xx unknown
- 1981-07-10 DK DK306781A patent/DK149851C/da not_active IP Right Cessation
- 1981-07-10 AU AU72731/81A patent/AU540916B2/en not_active Ceased
- 1981-07-10 GR GR65470A patent/GR74333B/el unknown
- 1981-07-10 GB GB8121321A patent/GB2080296B/en not_active Expired
- 1981-07-10 NO NO812355A patent/NO158578C/no unknown
- 1981-07-10 IE IE1567/81A patent/IE52508B1/en unknown
- 1981-07-10 FI FI812183A patent/FI74703C/fi not_active IP Right Cessation
- 1981-07-10 DD DD81231670A patent/DD202018A5/de unknown
- 1981-07-10 IL IL63285A patent/IL63285A/xx unknown
- 1981-07-10 ES ES503837A patent/ES8205402A1/es not_active Expired
- 1981-07-10 HU HU812036A patent/HU183515B/hu unknown
- 1981-07-11 KR KR8102523A patent/KR850000755B1/ko not_active Expired
- 1981-07-13 JP JP56109186A patent/JPS5748975A/ja active Pending
-
1982
- 1982-01-12 ES ES508655A patent/ES8300727A1/es not_active Expired
- 1982-01-12 ES ES508653A patent/ES508653A0/es active Granted
- 1982-01-12 ES ES508654A patent/ES508654A0/es active Granted
-
1986
- 1986-09-26 SG SG776/86A patent/SG77686G/en unknown
- 1986-12-18 HK HK982/86A patent/HK98286A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980921 |