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ES8300710A1 - "prodedimiento para la preparacion de derivados de fenoxi-aminipropanol" - Google Patents

"prodedimiento para la preparacion de derivados de fenoxi-aminipropanol"

Info

Publication number
ES8300710A1
ES8300710A1 ES508811A ES508811A ES8300710A1 ES 8300710 A1 ES8300710 A1 ES 8300710A1 ES 508811 A ES508811 A ES 508811A ES 508811 A ES508811 A ES 508811A ES 8300710 A1 ES8300710 A1 ES 8300710A1
Authority
ES
Spain
Prior art keywords
formula
substituted phenoxy
intermediates
preparation
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508811A
Other languages
English (en)
Other versions
ES508811A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES508811A0 publication Critical patent/ES508811A0/es
Publication of ES8300710A1 publication Critical patent/ES8300710A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FENOXI-AMINOPOPANOL SUSTITUIDOS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES ALQUILO INFERIOR; Y ES METILENO, ETILENO O PROPILENO; Y Z ES UN ANILLO HETEROCICLICO AROMATICO CON UNO O MAS ATOMOS DE N COMO UNICO HETEROATOMO, EVENTUALMENTE SUSTITUIDO. CONSISTE EN LA REACCION DE UN DERIVADO DE METAL ALCALINO DE UN FENOL DE FORMULA (II) CON UN COMPUESTO DE FORMULA R -Y-Z, EN LAS QUE R ES UN GRUPO SALIENTE; Y R, Y Y Z TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I)> LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA PROXIMA A 60<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FAMACOLOGICAS PARA EL TRATAMIENTO DE LA ANGINA DE PECHO Y ARRITMICAS CARDIACAS Y COMO AGENTES ANTIHIPERTENSIVOS.
ES508811A 1980-02-25 1982-01-16 "prodedimiento para la preparacion de derivados de fenoxi-aminipropanol" Expired ES8300710A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8006261 1980-02-25
GB8035997 1980-11-10

Publications (2)

Publication Number Publication Date
ES508811A0 ES508811A0 (es) 1982-11-16
ES8300710A1 true ES8300710A1 (es) 1982-11-16

Family

ID=26274605

Family Applications (2)

Application Number Title Priority Date Filing Date
ES499729A Expired ES8203847A1 (es) 1980-02-25 1981-02-24 Procedimiento para la preparacion de derivados de fenoxi- aminopropanol
ES508811A Expired ES8300710A1 (es) 1980-02-25 1982-01-16 "prodedimiento para la preparacion de derivados de fenoxi-aminipropanol"

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES499729A Expired ES8203847A1 (es) 1980-02-25 1981-02-24 Procedimiento para la preparacion de derivados de fenoxi- aminopropanol

Country Status (19)

Country Link
US (3) US4387100A (es)
EP (1) EP0034831B1 (es)
AR (2) AR228052A1 (es)
AT (1) ATE10746T1 (es)
AU (1) AU538505B2 (es)
CA (1) CA1156661A (es)
DE (1) DE3167672D1 (es)
DK (1) DK85281A (es)
ES (2) ES8203847A1 (es)
FI (1) FI810495L (es)
GR (1) GR74040B (es)
HU (1) HU184383B (es)
IE (1) IE50962B1 (es)
IL (1) IL62167A (es)
MC (1) MC1375A1 (es)
NO (1) NO810631L (es)
NZ (1) NZ196294A (es)
PH (1) PH16930A (es)
PT (1) PT72565B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57188570A (en) * 1981-05-14 1982-11-19 Shionogi & Co Ltd Benzylazole derivative
IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2584070B1 (fr) * 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux derives de l'hydroxy alkoxy 4-phenyl propyl indole, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant.
FR2584713B1 (fr) * 1985-07-11 1988-09-09 Roussel Uclaf Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US4769472A (en) * 1985-10-24 1988-09-06 Hoechst-Roussel Pharmaceuticals, Inc. Intermediate thieno-isoxazoles and -pyrazoles and 5-benzoyl-4-bromothiophenes
EP1890694A4 (en) * 2005-06-02 2010-10-27 Bayer Cropscience Ag SUBSTITUTED PHENYLALKYL HETEROARYL DERIVATIVES

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2414M (fr) * 1962-11-28 1964-03-23 Diathera Médicament analgésique, anti-inflammatoire et vasodilatateur périphérique a base d'[(ω-diméthylaminoéthoxy)-2' phényl]-3 méthyl-4 pyrazole.
GB1069343A (en) * 1963-09-10 1967-05-17 Ici Ltd Propanolamine derivatives
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE2619164C2 (de) * 1976-04-30 1985-07-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung
DE2732750A1 (de) * 1977-07-20 1979-02-08 Merck Patent Gmbh Basische thioaether und verfahren zu ihrer herstellung
US4263325A (en) * 1977-10-05 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
IT1097314B (it) * 1978-07-26 1985-08-31 Recordati Chem Pharm Derivati dell'imidazolo ad attivita' anticonvulsivante
PT71174A (fr) * 1979-05-04 1980-05-01 Continental Pharma Procede pour preparer derives de phenylethylamines
DE2926517A1 (de) * 1979-06-30 1981-01-15 Beiersdorf Ag Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0034831A3 (en) 1982-05-19
PH16930A (en) 1984-04-17
US4577030A (en) 1986-03-18
PT72565B (en) 1982-10-21
HU184383B (en) 1984-08-28
AR228052A1 (es) 1983-01-14
ATE10746T1 (de) 1984-12-15
IL62167A (en) 1985-08-30
AU6741281A (en) 1981-09-03
ES508811A0 (es) 1982-11-16
IE50962B1 (en) 1986-08-20
US4387100A (en) 1983-06-07
IE810373L (en) 1981-08-25
NZ196294A (en) 1984-07-31
DE3167672D1 (en) 1985-01-24
EP0034831A2 (de) 1981-09-02
NO810631L (no) 1981-08-26
AR227080A1 (es) 1982-09-15
PT72565A (en) 1981-03-01
FI810495A7 (fi) 1981-08-26
FI810495L (fi) 1981-08-26
US4663462A (en) 1987-05-05
MC1375A1 (fr) 1982-01-19
DK85281A (da) 1981-08-26
AU538505B2 (en) 1984-08-16
ES499729A0 (es) 1982-05-01
ES8203847A1 (es) 1982-05-01
GR74040B (es) 1984-06-06
IL62167A0 (en) 1981-03-31
CA1156661A (en) 1983-11-08
EP0034831B1 (de) 1984-12-12

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