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ES8207553A1 - Un procedimiento para la preparacion de dipeptidil-4-0,60-2-amino-2-desoxi-d-glucosa. - Google Patents

Un procedimiento para la preparacion de dipeptidil-4-0,60-2-amino-2-desoxi-d-glucosa.

Info

Publication number
ES8207553A1
ES8207553A1 ES501457A ES501457A ES8207553A1 ES 8207553 A1 ES8207553 A1 ES 8207553A1 ES 501457 A ES501457 A ES 501457A ES 501457 A ES501457 A ES 501457A ES 8207553 A1 ES8207553 A1 ES 8207553A1
Authority
ES
Spain
Prior art keywords
hydrogen
amino
preparation
deoxy
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501457A
Other languages
English (en)
Other versions
ES501457A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES501457A0 publication Critical patent/ES501457A0/es
Publication of ES8207553A1 publication Critical patent/ES8207553A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE FIPEPTIDIL-4-0, 6-0-2-AMINO-2-DESOXI-D-GLUCOSA. SE HACE REACCIONAR EL COMPUESTO (I) EN QUE P ES HIDROGENO, UN GRUPO PROTECTOR O R3; P'' ES HIDROGENO, UN GRUPO PROTECTOR O R4; CON UN DERIVADO REACTIVO DE FORMULA R34OH2. SE OBTIENE EL COMPUESTO (II). R1 ES ALQUILO, FENILO O FENILO SUSTITUIDO; R2 ES HIDROGENO, ALQUILO, FENILO, O FENIL-ALQUILO; R3 Y R4 SON HIDROGENO. R5 ES HIDROGENO O ALQUILO; R0 ES HIDROGENO; R7 ES HIDROGENO, ALQUILO, HIDROXIMETILO.
ES501457A 1980-04-17 1981-04-15 Un procedimiento para la preparacion de dipeptidil-4-0,60-2-amino-2-desoxi-d-glucosa. Expired ES8207553A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/141,227 US4368190A (en) 1980-04-17 1980-04-17 Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation

Publications (2)

Publication Number Publication Date
ES501457A0 ES501457A0 (es) 1982-09-16
ES8207553A1 true ES8207553A1 (es) 1982-09-16

Family

ID=22494746

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501457A Expired ES8207553A1 (es) 1980-04-17 1981-04-15 Un procedimiento para la preparacion de dipeptidil-4-0,60-2-amino-2-desoxi-d-glucosa.

Country Status (10)

Country Link
US (1) US4368190A (es)
EP (1) EP0038750B1 (es)
JP (1) JPS56164196A (es)
AT (1) ATE23537T1 (es)
CA (1) CA1174232A (es)
DE (1) DE3175602D1 (es)
DK (1) DK172481A (es)
ES (1) ES8207553A1 (es)
GR (1) GR76828B (es)
PT (1) PT72866B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8609353A1 (es) * 1984-05-29 1986-09-01 Ciba Geigy Ag Procedimiento para la obtencion de un derivado del azucar
US4640911A (en) * 1985-05-29 1987-02-03 Ciba-Geigy Corporation Acylated sugar derivatives, processes for their manufacture, and their use
US4937077A (en) * 1987-09-21 1990-06-26 Eastman Kodak Company Method for improving feed conversion of meat-producing animals by oral administration of 2-deoxy-D-hexose
US4866035A (en) * 1987-10-05 1989-09-12 Merck & Co., Inc. Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
WO1995031998A1 (en) * 1994-05-23 1995-11-30 The Research & Development Institute, Inc. Candida albicans adhesin as a vaccine
US6488929B2 (en) 1994-05-23 2002-12-03 Montana State University Candida albicans phosphomannan complex as a vaccine
US6309642B1 (en) 1997-04-28 2001-10-30 The Research And Development Institute, Inc. Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
DE19631189A1 (de) * 1996-08-02 1998-02-05 Max Delbrueck Centrum Neuartige kationische Amphiphile für den liposomalen Gentransfer
US20030072775A1 (en) * 1997-04-28 2003-04-17 The Research And Development Institute Inc. Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
CN1301847A (zh) * 1999-12-27 2001-07-04 上海博德基因开发有限公司 一种新的多肽——脂肪氧化酶10和编码这种多肽的多核苷酸
CN1313389A (zh) * 2000-03-15 2001-09-19 上海博德基因开发有限公司 一种新的多肽——人脂肪氧化酶9和编码这种多肽的多核苷酸
EP2217224B1 (en) 2007-11-09 2019-05-08 Basf As Lipid compounds for use in cosmetic products, as food supplement or as a medicament
EP2147910A1 (en) * 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
AU2010244136B2 (en) 2009-05-08 2016-05-12 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
TW201136942A (en) 2009-12-18 2011-11-01 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
WO2012059818A1 (en) 2010-11-05 2012-05-10 Pronova Biopharma Norge As Methods of treatment using lipid compounds
AU2014222389B2 (en) 2013-02-28 2018-11-29 Pronova Biopharma Norge As A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
KR102644400B1 (ko) 2015-04-28 2024-03-06 바스프 에이에스 비알코올성 지방간염의 예방 및/또는 치료를 위한 구조적으로 강화된 함황 지방산의 용도
CA3084728A1 (en) 2017-12-06 2019-06-13 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2288527A2 (fr) 1974-10-22 1976-05-21 Anvar Compositions contenant de la n-acetyl-muramyl- l-alanyl - d-isoglutamine ou de l'acide n-acetyl-muramyl-l-alanyl - d-glutamique, exemptes d'huile et ayant des proprietes adjuvantes
SE7607300L (sv) 1975-08-13 1977-02-14 Kefalas As Tiaxantenforeningar samt forfarande for framstellning av dem
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
GB1571133A (en) * 1976-04-26 1980-07-09 Syntex Inc Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
JPS5479228A (en) * 1977-12-02 1979-06-25 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
JPS5479227A (en) * 1977-12-02 1979-06-25 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
CA1138436A (en) * 1978-02-24 1982-12-28 Gerhard Baschang Process for the manufacture of novel antigens
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
JPS54130517A (en) * 1978-03-31 1979-10-09 Yuuichi Yamamura Muramyldipeptide higher fatty acid ester
HU186585B (en) * 1978-05-18 1985-08-28 Ciba Geigy Ag Process for producing new muramil-peptide derivatives
FR2428051A1 (fr) * 1978-06-05 1980-01-04 Anvar Nouveaux composes du type muramyl-peptide et medicaments les contenant
FR2449697A1 (fr) * 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) * 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation

Also Published As

Publication number Publication date
ATE23537T1 (de) 1986-11-15
US4368190A (en) 1983-01-11
EP0038750B1 (en) 1986-11-12
JPS56164196A (en) 1981-12-17
DE3175602D1 (en) 1987-01-02
ES501457A0 (es) 1982-09-16
PT72866B (en) 1985-11-25
CA1174232A (en) 1984-09-11
DK172481A (da) 1981-10-18
PT72866A (en) 1981-05-01
EP0038750A1 (en) 1981-10-28
GR76828B (es) 1984-09-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000403