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ES8207169A1 - Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.

Info

Publication number
ES8207169A1
ES8207169A1 ES499377A ES499377A ES8207169A1 ES 8207169 A1 ES8207169 A1 ES 8207169A1 ES 499377 A ES499377 A ES 499377A ES 499377 A ES499377 A ES 499377A ES 8207169 A1 ES8207169 A1 ES 8207169A1
Authority
ES
Spain
Prior art keywords
piperazinylquinazoline
derivatives
dimethoxy
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499377A
Other languages
English (en)
Other versions
ES499377A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1677580A external-priority patent/JPS56113770A/ja
Priority claimed from JP5275480A external-priority patent/JPS56150072A/ja
Priority claimed from JP9610680A external-priority patent/JPS5721384A/ja
Priority claimed from JP9610780A external-priority patent/JPS5721385A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES499377A0 publication Critical patent/ES499377A0/es
Publication of ES8207169A1 publication Critical patent/ES8207169A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE PIPERAZONILQUINAZOLINA Y DE HOMOPIPERAZINILQUINAZOLINA CON ACTIVIAD HIPERTENSORA. CONSISTE EN LA CONDENSACION DE UN DERIVADO DE QUINAZOLINA CON UN COMPUESTO DE CARBONILO DE FORMULA B-CO-R. SI EL PRODUCTO OBTENIDO ES UNA BASE LIBRE DE FORMULA GENERAL (I), PUEDE SALIFICARSE, PARA PRODUCIR UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTBLE. SE OBTIENE EL COMPUESTO DE FORMULAGENERAL (I) EN QUE R ES UN GRUPO ALQUENILO, UN GRUPO ALQUINILO O UN GRUPO ALCADIENILO.
ES499377A 1980-02-13 1981-02-12 Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad. Expired ES8207169A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1677580A JPS56113770A (en) 1980-02-13 1980-02-13 Novel quinazoline derivative and its preparation
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
JP9610680A JPS5721384A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
ES499377A0 ES499377A0 (es) 1982-09-01
ES8207169A1 true ES8207169A1 (es) 1982-09-01

Family

ID=27456647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499377A Expired ES8207169A1 (es) 1980-02-13 1981-02-12 Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.

Country Status (9)

Country Link
US (1) US4426382A (es)
CA (1) CA1154765A (es)
CH (1) CH644857A5 (es)
DE (1) DE3105330A1 (es)
ES (1) ES8207169A1 (es)
FR (1) FR2475548A1 (es)
GB (1) GB2068961B (es)
IT (1) IT1172225B (es)
NL (1) NL191208C (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
CA2647678A1 (en) * 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CA2687931C (en) 2007-05-31 2016-05-24 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
MX346393B (es) 2009-12-17 2017-03-17 Centrexion Therapeutics Corp Nuevos antagonistas del receptor ccr2 y usos de los mismo.
JP5646736B2 (ja) 2010-05-12 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011144501A1 (en) 2010-05-17 2011-11-24 Boehringer Ingelheim International Gmbh Ccr2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
US9260441B2 (en) * 2012-03-28 2016-02-16 Intervet Inc. Heteroaryl compounds with cyclic bridging unit
WO2013192345A1 (en) 2012-06-20 2013-12-27 Novartis Ag Complement pathway modulators and uses thereof
US9732077B2 (en) 2013-12-18 2017-08-15 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
WO2019010180A1 (en) * 2017-07-06 2019-01-10 Case Western Reserve University PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND USES THEREOF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3635979A (en) 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
JPS536156B2 (es) * 1972-10-30 1978-03-04
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4189484A (en) * 1977-11-08 1980-02-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Antihypertensive quinazoline derivatives
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
JPS5728576A (en) * 1980-07-24 1982-02-16 Toshiba Corp Inverter device

Also Published As

Publication number Publication date
GB2068961B (en) 1983-11-30
CA1154765A (en) 1983-10-04
FR2475548B1 (es) 1983-06-24
DE3105330C2 (es) 1991-07-25
ES499377A0 (es) 1982-09-01
NL191208C (nl) 1995-03-16
IT8167213A0 (it) 1981-02-13
FR2475548A1 (fr) 1981-08-14
NL191208B (nl) 1994-10-17
CH644857A5 (de) 1984-08-31
GB2068961A (en) 1981-08-19
DE3105330A1 (de) 1981-12-17
US4426382A (en) 1984-01-17
NL8100726A (nl) 1981-09-16
IT1172225B (it) 1987-06-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612