[go: up one dir, main page]

ES8202334A1 - Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina - Google Patents

Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina

Info

Publication number
ES8202334A1
ES8202334A1 ES496442A ES496442A ES8202334A1 ES 8202334 A1 ES8202334 A1 ES 8202334A1 ES 496442 A ES496442 A ES 496442A ES 496442 A ES496442 A ES 496442A ES 8202334 A1 ES8202334 A1 ES 8202334A1
Authority
ES
Spain
Prior art keywords
hydrogen
carbon atoms
atom
alkyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496442A
Other languages
English (en)
Other versions
ES496442A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES8202334A1 publication Critical patent/ES8202334A1/es
Publication of ES496442A0 publication Critical patent/ES496442A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIETO PARA LA OBTENCION DE DERIVADOS DE 2,4-DIAMINOQUINAZOLINA Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Y1 ES UN HIDROGENO O CLORO; Y2 ES OR, DDE R ES ALQUILO C1-3; Y3 ES HIDROGENO U OR; Y R3 Y R2 PUEDEN SER VARIOS TIPOS E RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) Y UNA MINA DE FORMULA R1R2NH, EN LA QUE L1 Y L2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y R1, R2, Y1, Y2 E Y3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO O ACUOSO A UNA TEMPERATURA ENTRE 10 Y 160 C. ESTOS COMUPUESTO TIENEN APLICACIONES FARMACOLAOGICAS COMO AGENTES ATIHIPERTENSIVO
ES80496442A 1979-11-01 1980-10-31 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina Granted ES496442A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9031379A 1979-11-01 1979-11-01
US06/126,838 US4287341A (en) 1979-11-01 1980-03-03 Alkoxy-substituted-6-chloro-quinazoline-2,4-diones

Publications (2)

Publication Number Publication Date
ES8202334A1 true ES8202334A1 (es) 1982-01-16
ES496442A0 ES496442A0 (es) 1982-01-16

Family

ID=26782146

Family Applications (5)

Application Number Title Priority Date Filing Date
ES80496442A Granted ES496442A0 (es) 1979-11-01 1980-10-31 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina
ES507042A Granted ES507042A0 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES507041A Granted ES507041A0 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES507043A Expired ES8207520A1 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES516286A Granted ES516286A0 (es) 1979-11-01 1982-10-06 "un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina".

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES507042A Granted ES507042A0 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES507041A Granted ES507041A0 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES507043A Expired ES8207520A1 (es) 1979-11-01 1981-11-11 Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina.
ES516286A Granted ES516286A0 (es) 1979-11-01 1982-10-06 "un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina".

Country Status (15)

Country Link
US (1) US4287341A (es)
EP (1) EP0028473B1 (es)
AR (1) AR227650A1 (es)
AU (1) AU520344B2 (es)
CA (1) CA1146546A (es)
DE (1) DE3069944D1 (es)
DK (1) DK153399C (es)
ES (5) ES496442A0 (es)
FI (1) FI77455C (es)
GR (1) GR70728B (es)
IE (1) IE50366B1 (es)
IL (1) IL61375A (es)
PH (3) PH17552A (es)
PT (1) PT72007B (es)
YU (1) YU41745B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
US4426382A (en) 1980-02-13 1984-01-17 Sankyo Company Limited 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines
FI70411C (fi) 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
ES515338A0 (es) * 1981-09-09 1983-11-01 Orion Yhtymae Oy "metodo para la preparacion de piperidinilquinazolidinas substituidas".
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
CH651027A5 (de) * 1982-11-12 1985-08-30 Sandoz Ag Heterocyclische verbindungen, ihre herstellung und verwendung.
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
US4933460A (en) * 1983-08-22 1990-06-12 Hoechst-Roussel Pharmaceuticals Inc. Piperdine substituted phenyl hydrazones
US4634769A (en) * 1984-09-25 1987-01-06 Ortho Pharmaceutical Corporation Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts
FR2582513B1 (fr) * 1985-05-28 1988-08-05 Synthelabo Compositions pharmaceutiques contenant de l'alfuzosine
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
US4668787A (en) * 1985-12-20 1987-05-26 Ortho Pharmaceutical Corporation 5,6-dialkoxy-4-imino-2(1H)quinazolinone derivatives
US4672116A (en) * 1985-12-20 1987-06-09 Ortho Pharmaceutical Corporation Substituted 5,6-dialkoxyquinazoline derivatives
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
EP0360936A1 (de) * 1988-09-29 1990-04-04 Siemens Aktiengesellschaft Österreich Verfahren zur Wandlung des Abtastsignals eines analogen Eingangssignals
EP0367888A1 (en) * 1988-11-08 1990-05-16 ISTITUTO LUSO FARMACO D'ITALIA S.p.A. 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
WO1992007844A1 (en) * 1990-11-06 1992-05-14 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
IL108630A0 (en) * 1993-02-18 1994-05-30 Fmc Corp Insecticidal substituted 2,4-diaminoquinazolines
DE4429978A1 (de) * 1994-08-24 1996-02-29 Bayer Ag Verfahren zur Herstellung von Chinazolin-2,4-dionen
US5747490A (en) * 1995-09-29 1998-05-05 Merck & Co., Inc. Alpha 1b adrenergic receptor antagonists
AU7692996A (en) * 1995-12-01 1997-06-27 Ciba-Geigy Ag Receptor antagonists
CA2173408C (en) * 1996-04-03 2001-09-04 K.S. Keshava Murthy Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines
IT1286302B1 (it) * 1996-04-10 1998-07-08 Rotta Research Lab Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
DZ3415A1 (fr) * 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
DE60216747T2 (de) * 2001-04-09 2007-10-04 Novartis Vaccines and Diagnostics, Inc., Emeryville Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
WO2003072056A2 (en) * 2002-02-25 2003-09-04 Chiron Corporation Intranasal administration of mc4-r agonists
EP1551834B1 (en) * 2002-05-23 2010-08-25 Novartis Vaccines and Diagnostics, Inc. Substituted quinazolinone compounds
EP1539754A4 (en) 2002-08-23 2009-02-25 Novartis Vaccines & Diagnostic BENZIMIDAZOCHINOLINONE AND ITS USE
ATE411996T1 (de) 2002-09-30 2008-11-15 Bayer Healthcare Ag Kondensierte azolpyrimidinderivate
US6608200B1 (en) * 2002-10-07 2003-08-19 Council Of Scientific & Industrial Research Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine
CA2523015A1 (en) * 2003-05-23 2004-12-29 Chiron Corporation Guanidino-substituted quinazolinone compounds as mc4-r agonists
JP4823914B2 (ja) 2003-11-07 2011-11-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｆｇｆｒ３の阻害および多発性骨髄腫の治療
WO2005051391A1 (en) * 2003-11-19 2005-06-09 Chiron Corporation Quinazolinone compounds with reduced bioaccumulation
RU2007115900A (ru) * 2004-10-27 2008-11-10 Дайити Санкио Компани, Лимитед (Jp) Производные бензола, имеющие 2 или более заместителей
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
EP2640366A2 (en) 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
CN113105350B (zh) * 2021-04-06 2023-11-24 利尔化学股份有限公司 制备2-氨基-3-烷基-5-氯苯甲酸的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1117130B (de) * 1959-10-14 1961-11-16 Basf Ag Verfahren zur Herstellung von 2, 4-Dihydroxychinazolinen
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
DE2027645A1 (de) * 1970-06-05 1971-12-09 Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
GB1334633A (en) * 1972-04-07 1973-10-24 Parke Davis & Co Quinazoline compounds and methods for their production
JPS536156B2 (es) * 1972-10-30 1978-03-04
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4001238A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company 1,3,4-oxadiazole amides
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
US4098788A (en) * 1977-06-20 1978-07-04 Bristol-Myers Company Process for preparing quinazolines
US4102885A (en) * 1977-06-20 1978-07-25 Bristol-Myers Company Process for preparing 2,4-dihaloquinazolines

Also Published As

Publication number Publication date
DK462380A (da) 1981-05-02
ES8206491A1 (es) 1982-08-16
AR227650A1 (es) 1982-11-30
AU520344B2 (en) 1982-01-28
YU41745B (en) 1987-12-31
IL61375A0 (en) 1980-12-31
FI803397L (fi) 1981-05-02
ES507042A0 (es) 1982-08-16
IL61375A (en) 1986-09-30
CA1146546A (en) 1983-05-17
PH18321A (en) 1985-05-29
EP0028473B1 (en) 1985-01-09
DK153399B (da) 1988-07-11
PH17552A (en) 1984-09-20
EP0028473A1 (en) 1981-05-13
ES507043A0 (es) 1982-10-01
ES8303360A1 (es) 1983-02-01
IE802258L (en) 1981-05-01
DE3069944D1 (en) 1985-02-21
IE50366B1 (en) 1986-04-02
US4287341A (en) 1981-09-01
ES8207520A1 (es) 1982-10-01
ES8400415A1 (es) 1983-10-16
GR70728B (es) 1983-01-24
ES516286A0 (es) 1983-10-16
PT72007B (en) 1981-08-31
AU6389680A (en) 1981-05-07
YU277580A (en) 1983-06-30
DK153399C (da) 1988-12-19
FI77455B (fi) 1988-11-30
FI77455C (fi) 1989-03-10
ES507041A0 (es) 1983-02-01
PT72007A (en) 1980-11-01
PH20061A (en) 1986-09-18
ES496442A0 (es) 1982-01-16

Similar Documents

Publication Publication Date Title
ES8202334A1 (es) Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina
ES2137915T3 (es) Derivados de tiazolidindiona sustituida.
IE792074L (en) Pyran- and thiopyran-fused heterocyclic compounds
IL100899A (en) Beta-amino-alpha- hydroxycarboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
MX9206939A (es) Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
FI943561A0 (fi) Uudet ainekoostumukset
ES474215A1 (es) Procedimiento para la preparacion de derivados imidazolile- tiloxialcoxilicos y sus analogos con agrupacion tio
HUP0100184A2 (hu) Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
ES475173A1 (es) Procedimiento para la fabricacion de quinazolinas.
NO960441L (no) Benzopyraner og farmasöytiske forbindelser inneholdende dem
ES2057802T3 (es) Nuevos derivados de 3-amino-cromano, procedimiento de preparacion y composiciones farmaceuticas que los contienen.
SE8800171L (sv) Nya 5-oxi-derivat av tetrahydrofuran
ES2132245T3 (es) Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.
UA50722C2 (uk) Нітробензаміди, спосіб їх одержання (варіанти), фармацевтична композиція
ES8403129A1 (es) Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas.
SE8501988L (sv) Iminotiazolidinderivat
ES8105309A1 (es) Un procedimiento para la preparacion de nuevos derivados de cromano.
ES547604A0 (es) Un procedimiento para preparar derivados de 2-piridin-tiol
ES8201140A1 (es) Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas.
ZA831477B (en) Substituted pyridines,processes for preparing these and pharmaceutical composition thereof
IL74556A (en) Derivatives of 1,5-diaryl-1,2,4-thiadiazine 1-oxide,their preparation and pharmaceutical compositions containing them
ES8207177A1 (es) Procedimiento para preparar nuevos derivados de triazoloqui-nazolinona
ES8403130A1 (es) Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas.
SE7905051L (sv) Nya sulfonamider
ES8104242A1 (es) Un procedimiento para la preparacion de nuevos derivados de hidantoina.