ES8201986A1 - Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona - Google Patents
Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-dionaInfo
- Publication number
- ES8201986A1 ES8201986A1 ES499471A ES499471A ES8201986A1 ES 8201986 A1 ES8201986 A1 ES 8201986A1 ES 499471 A ES499471 A ES 499471A ES 499471 A ES499471 A ES 499471A ES 8201986 A1 ES8201986 A1 ES 8201986A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- preparation
- phenyl
- analogons
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE 1,2,4-TRIAZOLIDIN-3,5-DIONA, DE FORMULA (I), EN QUE Y ES ETILO, ETENILO O ETINILO; R1 Y R5 SON ALQUILO; R2 HIDROGENO; R3 HIDROXILO, Y R4 HIDROGENO, ALQUILO, CICLOAQLUILO U OTROS. SE HACE REACCIONAR CON UN REACTIVO NUCLEOFILO DEL GRUPO CARBONILO TAL COMO UN COMPUESTO ORGANOMETALICO REACTIVO DE GRIGNARD, UN COMPUESTO DE FORMULA (II), EN QUE R22 Y R13 CON IGUALES A R2 Y R3, O FORMAN ENTRE SI UN GRUPO OXO; R16 ES HIDROXI; R7 ES HIDROGENO O FORMA CON R16 UN GRUPO DE OXO; EN PRESENCIA DE BOROHIDUROS O EN UN DISOLVENTE TAL COMO DIGLIMA. POSTERIORMENTE, CASO DE ESTAR PROTEGIDO EL GRUPO R16, SE DESPROTEGE POR REACCIONES DE DESALQUILACION O DESACILACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7924235 | 1979-07-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES499471A0 ES499471A0 (es) | 1982-01-16 |
| ES8201986A1 true ES8201986A1 (es) | 1982-01-16 |
Family
ID=10506447
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493339A Granted ES493339A0 (es) | 1979-07-12 | 1980-07-11 | Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5- diona. |
| ES499471A Expired ES8201986A1 (es) | 1979-07-12 | 1981-02-16 | Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493339A Granted ES493339A0 (es) | 1979-07-12 | 1980-07-11 | Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5- diona. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0024105A1 (es) |
| JP (1) | JPS5615275A (es) |
| AU (1) | AU6031280A (es) |
| DK (1) | DK302980A (es) |
| ES (2) | ES493339A0 (es) |
| IL (1) | IL60544A0 (es) |
| ZA (1) | ZA804188B (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0007180B1 (en) * | 1978-06-15 | 1983-03-30 | Beecham Group Plc | Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them |
-
1980
- 1980-07-01 EP EP80302206A patent/EP0024105A1/en not_active Withdrawn
- 1980-07-10 AU AU60312/80A patent/AU6031280A/en not_active Abandoned
- 1980-07-10 IL IL60544A patent/IL60544A0/xx unknown
- 1980-07-11 DK DK302980A patent/DK302980A/da unknown
- 1980-07-11 ES ES493339A patent/ES493339A0/es active Granted
- 1980-07-11 ZA ZA00804188A patent/ZA804188B/xx unknown
- 1980-07-12 JP JP9555980A patent/JPS5615275A/ja active Pending
-
1981
- 1981-02-16 ES ES499471A patent/ES8201986A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA804188B (en) | 1981-07-29 |
| ES499471A0 (es) | 1982-01-16 |
| ES8106146A1 (es) | 1981-07-16 |
| EP0024105A1 (en) | 1981-02-25 |
| IL60544A0 (en) | 1980-09-16 |
| DK302980A (da) | 1981-01-13 |
| ES493339A0 (es) | 1981-07-16 |
| AU6031280A (en) | 1981-01-15 |
| JPS5615275A (en) | 1981-02-14 |
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