ES8200872A1 - Substituted-phenylpyridines and preparation - Google Patents
Substituted-phenylpyridines and preparationInfo
- Publication number
- ES8200872A1 ES8200872A1 ES497787A ES497787A ES8200872A1 ES 8200872 A1 ES8200872 A1 ES 8200872A1 ES 497787 A ES497787 A ES 497787A ES 497787 A ES497787 A ES 497787A ES 8200872 A1 ES8200872 A1 ES 8200872A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridine
- preparation
- reaction
- phenylpyridines
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE 4 (O 3)-(3,4-DIHIDROXIFENIL) PIRIDINA. SE BASA EN LA REACCION, A TEMPERATURA DE 100-120 C, DE 4 (O 3)-(3,4-DIMETOXIFENIL) PIRIDINA, CON UN AGENTE DESMETILANTE, TAL COMO BROMURO DE HIDROGENO ACUOSO, YODURO DE HIDROGENO, CLORHIDRATO DE PIRIDINA, U OTROS. SE DEJA REPOSAR LA MEZCLA UNOS DIAS. SE LAVA CON ETANOL EL PRECIPITADO RESULTANTE, SE SECA EN UN HORNO A 80-95 C, Y SE RECOGE EL PRODUCTO FINAL EN FORMA DE SAL. SE OBTIENE EN FORMA DE BASE LIBRE, POR REACCION DE UNA SOLUCION ACUOSA DE LA SAL, CON UN EXCESO DE SOLUCION DE BICARBONATO SODICO, Y POSTERIOR FILTRACION. SE USAN COMO AGENTES CARDIOTONICOS.PROCEDURE FOR THE PREPARATION OF 4 (O 3) - (3,4-DIHYDROXYPHENIL) PYRIDINE. IT IS BASED ON THE REACTION, AT A TEMPERATURE OF 100-120 C, OF 4 (O 3) - (3,4-DIMETOXIFENIL) PYRIDINE, WITH A DEMETILATING AGENT, SUCH AS AQUEOUS HYDROGEN BROMIDE, HYDROGEN IODIDE, PYRIDINE HYDROCHLORIDE, OR OTHERS. THE MIXTURE IS ALLOWED TO REST FOR A FEW DAYS. THE RESULTING PRECIPITATE IS WASHED WITH ETHANOL, DRIED IN AN OVEN AT 80-95 C, AND THE FINAL PRODUCT IS COLLECTED IN THE FORM OF SALT. IT IS OBTAINED IN A FREE BASE FORM, BY REACTION OF AN AQUEOUS SALT SOLUTION WITH AN EXCESS OF SODIUM BICARBONATE SOLUTION, AND SUBSEQUENT FILTRATION. THEY ARE USED AS CARDIOTONIC AGENTS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10585179A | 1979-12-20 | 1979-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200872A1 true ES8200872A1 (en) | 1981-11-16 |
| ES497787A0 ES497787A0 (en) | 1981-11-16 |
Family
ID=22308136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497787A Granted ES497787A0 (en) | 1979-12-20 | 1980-12-16 | A PROCEDURE TO PREPARE 4 (O3) - (3,4-DIHIDROXIFENIL) PIRIDINA |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS56118064A (en) |
| KR (1) | KR830004249A (en) |
| AR (1) | AR226442A1 (en) |
| AT (1) | AT374459B (en) |
| AU (1) | AU6515880A (en) |
| BE (1) | BE886675A (en) |
| DE (1) | DE3047615A1 (en) |
| DK (1) | DK536680A (en) |
| ES (1) | ES497787A0 (en) |
| FI (1) | FI803913L (en) |
| FR (1) | FR2471976A1 (en) |
| GB (1) | GB2065651B (en) |
| IL (1) | IL61676A (en) |
| IT (1) | IT1194006B (en) |
| LU (1) | LU83007A1 (en) |
| NL (1) | NL8006785A (en) |
| NO (1) | NO803790L (en) |
| NZ (1) | NZ195758A (en) |
| PH (1) | PH16466A (en) |
| PT (1) | PT72206B (en) |
| SE (1) | SE8008887L (en) |
| ZA (1) | ZA807781B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1183046A (en) * | 1966-06-28 | 1970-03-04 | Allen & Hanburys Ltd | Novel Heterocyclic Compounds |
-
1980
- 1980-12-04 NZ NZ195758A patent/NZ195758A/en unknown
- 1980-12-08 AU AU65158/80A patent/AU6515880A/en not_active Abandoned
- 1980-12-09 IL IL61676A patent/IL61676A/en unknown
- 1980-12-12 ZA ZA00807781A patent/ZA807781B/en unknown
- 1980-12-15 NL NL8006785A patent/NL8006785A/en not_active Application Discontinuation
- 1980-12-15 FI FI803913A patent/FI803913L/en not_active Application Discontinuation
- 1980-12-15 IT IT26661/80A patent/IT1194006B/en active
- 1980-12-15 GB GB8040121A patent/GB2065651B/en not_active Expired
- 1980-12-16 NO NO803790A patent/NO803790L/en unknown
- 1980-12-16 BE BE1/10076A patent/BE886675A/en not_active IP Right Cessation
- 1980-12-16 AT AT0613180A patent/AT374459B/en not_active IP Right Cessation
- 1980-12-16 PT PT72206A patent/PT72206B/en unknown
- 1980-12-16 FR FR8026689A patent/FR2471976A1/en not_active Withdrawn
- 1980-12-16 ES ES497787A patent/ES497787A0/en active Granted
- 1980-12-16 LU LU83007A patent/LU83007A1/en unknown
- 1980-12-17 AR AR283675A patent/AR226442A1/en active
- 1980-12-17 KR KR1019800004813A patent/KR830004249A/en not_active Ceased
- 1980-12-17 SE SE8008887A patent/SE8008887L/en not_active Application Discontinuation
- 1980-12-17 DE DE19803047615 patent/DE3047615A1/en not_active Withdrawn
- 1980-12-17 DK DK536680A patent/DK536680A/en unknown
- 1980-12-17 JP JP17867080A patent/JPS56118064A/en active Pending
- 1980-12-18 PH PH25004A patent/PH16466A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ195758A (en) | 1984-07-06 |
| LU83007A1 (en) | 1981-07-23 |
| DE3047615A1 (en) | 1981-09-17 |
| NL8006785A (en) | 1981-07-16 |
| AU6515880A (en) | 1981-06-25 |
| FR2471976A1 (en) | 1981-06-26 |
| ES497787A0 (en) | 1981-11-16 |
| IL61676A0 (en) | 1981-01-30 |
| GB2065651A (en) | 1981-07-01 |
| JPS56118064A (en) | 1981-09-16 |
| AR226442A1 (en) | 1982-07-15 |
| IT8026661A0 (en) | 1980-12-15 |
| KR830004249A (en) | 1983-07-09 |
| PH16466A (en) | 1983-10-20 |
| PT72206A (en) | 1981-01-01 |
| AT374459B (en) | 1984-04-25 |
| BE886675A (en) | 1981-06-16 |
| NO803790L (en) | 1981-06-22 |
| IT1194006B (en) | 1988-08-31 |
| FI803913A7 (en) | 1981-06-21 |
| GB2065651B (en) | 1983-10-05 |
| ZA807781B (en) | 1981-12-30 |
| FI803913L (en) | 1981-06-21 |
| DK536680A (en) | 1981-06-21 |
| PT72206B (en) | 1981-10-28 |
| IL61676A (en) | 1984-02-29 |
| ATA613180A (en) | 1983-09-15 |
| SE8008887L (en) | 1981-06-21 |
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