ES8200692A1 - Procedimiento para la preparacion de nuevas cefalosporinas - Google Patents
Procedimiento para la preparacion de nuevas cefalosporinasInfo
- Publication number
- ES8200692A1 ES8200692A1 ES498522A ES498522A ES8200692A1 ES 8200692 A1 ES8200692 A1 ES 8200692A1 ES 498522 A ES498522 A ES 498522A ES 498522 A ES498522 A ES 498522A ES 8200692 A1 ES8200692 A1 ES 8200692A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- preparation
- pharmaceutical compositions
- compositions containing
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- -1 PHENYL 4-HYDROXYPHENYL Chemical class 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE CEFALOSPORINAS DE FORMULA (I), EN DONDE A ES FENILO 4-HIDROXIFENILO, CICLOHEXILO U OTROS; D HIDROGENO, HIDROXI, ACETOXI Y OTROS; R HIDROGENO, METILO, CICLOPROPILO U OTROS, Y E HIDROGENO O UN GRUPO PROTECTOR FACILMENTE SEPARABLE "IN VITRO". SE HACE REACCIONAR A TEMPERATURA DE -120 A -10 C UN COMPUESTO D FORMULA (II) CON UN METILATO DE METAL ALCALINO, EN PRESENCIA DE METANOL EN EXCESO, Y EN UN MEDIO DISOLVENTE INERTE. LA MEZCLA DE REACCION SE TRATA CON UN AGENTE DE HALOHENACION, TAL COMO HALOGENOS, N-HALOGENOIMIDAS, ETC. UNA VEZ FINALIZADA LA REACCION, SE ELIMINA EL AGENTE DE HALOGENACION EN EXCESO MEDIANTE UN AGENTE REDUCTOR. DE APLICACION COMO AGENTES ANTIBIOTICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792924948 DE2924948A1 (de) | 1979-06-21 | 1979-06-21 | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200692A1 true ES8200692A1 (es) | 1981-11-01 |
| ES498522A0 ES498522A0 (es) | 1981-11-01 |
Family
ID=6073715
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491775A Granted ES491775A0 (es) | 1979-06-21 | 1980-05-23 | Procedimiento para la preparacion de nuevas cefalosporinas |
| ES498522A Granted ES498522A0 (es) | 1979-06-21 | 1981-01-15 | Procedimiento para la preparacion de nuevas cefalosporinas |
| ES498521A Expired ES8200691A1 (es) | 1979-06-21 | 1981-01-15 | Procedimiento para la preparacion de nuevas cefalosporinas |
| ES498520A Granted ES498520A0 (es) | 1979-06-21 | 1981-01-15 | Procedimiento para la preparacion de nuevas cefalosporinas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491775A Granted ES491775A0 (es) | 1979-06-21 | 1980-05-23 | Procedimiento para la preparacion de nuevas cefalosporinas |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498521A Expired ES8200691A1 (es) | 1979-06-21 | 1981-01-15 | Procedimiento para la preparacion de nuevas cefalosporinas |
| ES498520A Granted ES498520A0 (es) | 1979-06-21 | 1981-01-15 | Procedimiento para la preparacion de nuevas cefalosporinas |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US4316898A (es) |
| EP (1) | EP0021176B1 (es) |
| JP (1) | JPS567791A (es) |
| AT (1) | ATE5886T1 (es) |
| AU (1) | AU536982B2 (es) |
| CA (1) | CA1146537A (es) |
| DE (2) | DE2924948A1 (es) |
| DK (1) | DK261780A (es) |
| ES (4) | ES491775A0 (es) |
| FI (1) | FI68840C (es) |
| GR (1) | GR68107B (es) |
| HU (1) | HU184793B (es) |
| IE (1) | IE49922B1 (es) |
| IL (1) | IL60366A (es) |
| NO (1) | NO801848L (es) |
| NZ (1) | NZ194103A (es) |
| PH (1) | PH17717A (es) |
| PT (1) | PT71440B (es) |
| ZA (1) | ZA803710B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5643288A (en) * | 1979-09-18 | 1981-04-21 | Meiji Seika Kaisha Ltd | Cephalosporin derivative and its preparation |
| DE3007685A1 (de) * | 1980-02-29 | 1981-10-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue cephylosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3038501A1 (de) * | 1980-10-11 | 1982-05-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel |
| EP0053276A3 (de) * | 1980-12-02 | 1983-08-03 | Dr. Karl Thomae GmbH | Neue Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3047082A1 (de) * | 1980-12-13 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3134776A1 (de) * | 1981-09-02 | 1983-03-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 6(alpha)-methoxy-penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CN102675342A (zh) * | 2011-03-15 | 2012-09-19 | 四平市精细化学品有限公司 | 7β-氨基-7α-甲氧基-3-[（1-甲基-1H-四唑-5-基）硫甲基]-3-头孢烯-4-羧酸二苯甲酯的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR208171A1 (es) * | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
| DE2710979A1 (de) * | 1977-03-14 | 1978-09-21 | Merck Patent Gmbh | Lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| DE2650826A1 (de) * | 1976-11-06 | 1978-05-11 | Merck Patent Gmbh | Cephemderivate |
| DE2828261A1 (de) * | 1978-06-28 | 1980-01-10 | Thomae Gmbh Dr K | Neue penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1979
- 1979-06-21 DE DE19792924948 patent/DE2924948A1/de not_active Withdrawn
-
1980
- 1980-04-28 GR GR61798A patent/GR68107B/el unknown
- 1980-05-20 US US06/151,694 patent/US4316898A/en not_active Expired - Lifetime
- 1980-05-23 ES ES491775A patent/ES491775A0/es active Granted
- 1980-06-06 EP EP80103135A patent/EP0021176B1/de not_active Expired
- 1980-06-06 DE DE8080103135T patent/DE3066148D1/de not_active Expired
- 1980-06-06 AT AT80103135T patent/ATE5886T1/de active
- 1980-06-11 JP JP7887580A patent/JPS567791A/ja active Pending
- 1980-06-17 CA CA000354162A patent/CA1146537A/en not_active Expired
- 1980-06-17 PH PH24152A patent/PH17717A/en unknown
- 1980-06-19 FI FI801979A patent/FI68840C/fi not_active IP Right Cessation
- 1980-06-19 DK DK261780A patent/DK261780A/da not_active Application Discontinuation
- 1980-06-20 PT PT71440A patent/PT71440B/pt unknown
- 1980-06-20 IL IL60366A patent/IL60366A/xx unknown
- 1980-06-20 NZ NZ194103A patent/NZ194103A/en unknown
- 1980-06-20 AU AU59471/80A patent/AU536982B2/en not_active Ceased
- 1980-06-20 NO NO801848A patent/NO801848L/no unknown
- 1980-06-20 ZA ZA00803710A patent/ZA803710B/xx unknown
- 1980-06-20 IE IE1289/80A patent/IE49922B1/en unknown
- 1980-06-20 HU HU801544A patent/HU184793B/hu unknown
-
1981
- 1981-01-15 ES ES498522A patent/ES498522A0/es active Granted
- 1981-01-15 ES ES498521A patent/ES8200691A1/es not_active Expired
- 1981-01-15 ES ES498520A patent/ES498520A0/es active Granted
- 1981-09-30 US US06/307,117 patent/US4388315A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI801979A7 (fi) | 1980-12-22 |
| AU536982B2 (en) | 1984-05-31 |
| ES8200690A1 (es) | 1981-11-01 |
| CA1146537A (en) | 1983-05-17 |
| ES8200370A1 (es) | 1981-10-16 |
| FI68840C (fi) | 1985-11-11 |
| DE2924948A1 (de) | 1981-01-22 |
| ES491775A0 (es) | 1981-10-16 |
| EP0021176B1 (de) | 1984-01-18 |
| IE801289L (en) | 1980-12-21 |
| PT71440A (de) | 1980-07-01 |
| ATE5886T1 (de) | 1984-02-15 |
| IL60366A (en) | 1984-02-29 |
| AU5947180A (en) | 1981-01-08 |
| PH17717A (en) | 1984-11-21 |
| IL60366A0 (en) | 1980-09-16 |
| US4388315A (en) | 1983-06-14 |
| US4316898A (en) | 1982-02-23 |
| ZA803710B (en) | 1982-02-24 |
| EP0021176A3 (en) | 1981-12-23 |
| GR68107B (es) | 1981-10-30 |
| EP0021176A2 (de) | 1981-01-07 |
| HU184793B (en) | 1984-10-29 |
| ES498521A0 (es) | 1981-11-01 |
| DE3066148D1 (en) | 1984-02-23 |
| NO801848L (no) | 1980-12-22 |
| NZ194103A (en) | 1984-07-06 |
| ES498520A0 (es) | 1981-11-01 |
| PT71440B (de) | 1981-10-23 |
| ES8200691A1 (es) | 1981-11-01 |
| DK261780A (da) | 1980-12-22 |
| FI68840B (fi) | 1985-07-31 |
| JPS567791A (en) | 1981-01-27 |
| IE49922B1 (en) | 1986-01-08 |
| ES498522A0 (es) | 1981-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8603376A1 (es) | Un metodo para preparar derivados de alcanol aromaticos policiclicos | |
| ES8302671A1 (es) | "procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables". | |
| ES472661A1 (es) | Procedimiento para la preparacion de nuevos nitroimidazoles | |
| ATE7689T1 (de) | 1-(dihydroxyphenyl)-2-amino-aethanol-derivate, verfahren und mittel zu ihrer herstellung sowie diese derivate enthaltende mittel. | |
| PT81898A (de) | Neue thieno-triazolo-1,4-diazepino-2-carbonsaeureamide verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen | |
| SE7601755L (sv) | Anvendning av perfluoralkansulfonamider och/eller ammoniumsalter av perfluoralkansulfonsyror och/eller cyklimmoniumsalter av perfluoralkansulfonsyror som formsleppmedel for termoplastiska, hogmolekyllera, m m | |
| ES8500244A1 (es) | "un procedimiento para preparar derivados de pirazinona" | |
| ES8505966A1 (es) | Un procedimiento para la preparacion de compuestos de bencimidazol | |
| ES8200692A1 (es) | Procedimiento para la preparacion de nuevas cefalosporinas | |
| ES8404361A1 (es) | Un procedimiento para la preparacion de un derivado de cefalosporina. | |
| ES2000502A6 (es) | Un procedimiento para la preparacion de poli-4-aminopirrol-2-carboxamido derivados | |
| ES453161A1 (es) | Un procedimiento de preparacion de espiro (1,3-dioxolan-4,3)quinuclidinas. | |
| ES8301883A1 (es) | Procedimiento para la preparacion de derivados de ciclohexe-no | |
| ES8706148A1 (es) | Un procedimiento para preparar nuevos derivados de carbapenem. | |
| IE822551L (en) | Alkanes and alkenes | |
| ES8601209A1 (es) | Procedimiento para preparar derivados de 5h-(1)-benzopirano-(2,3-d)pirimidina | |
| GB990493A (en) | Agents for controlling plant growth | |
| JPS5626814A (en) | Antibacteria agent and its use | |
| ATE20588T1 (de) | Heterozyklische verbindungen geeignet als pestizide und verfahren zu ihrer herstellung. | |
| ES8702392A1 (es) | Un procedimiento para preparar compuestos heterociclicos, en particular compuestos con un anillo de tiadiazinona | |
| ES8200689A1 (es) | Un procedimiento para la produccion de analogos de cefalosporina. | |
| ES479440A1 (es) | Un procedimiento para preparar compuestos con propiedades broncodilatadoras. | |
| ATE12106T1 (de) | Naphtho(1,2-d)imidazole, verfahren zu ihrer herstellung, die verbindungen als entzuendungshemmende mittel und diese verbindungen enthaltende zusammensetzungen. | |
| ES8403482A1 (es) | Procedimiento para la preparacion de nuevas piridobenzodiazepinonas. | |
| ES8204992A1 (es) | Procedimiento para la obtencion de compuestos poliazahetero-ciclicos |