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ES8107251A1 - Un procedimiento para la preparacion de una 1- epi-2-dexoxifortimicina. - Google Patents

Un procedimiento para la preparacion de una 1- epi-2-dexoxifortimicina.

Info

Publication number
ES8107251A1
ES8107251A1 ES495314A ES495314A ES8107251A1 ES 8107251 A1 ES8107251 A1 ES 8107251A1 ES 495314 A ES495314 A ES 495314A ES 495314 A ES495314 A ES 495314A ES 8107251 A1 ES8107251 A1 ES 8107251A1
Authority
ES
Spain
Prior art keywords
hydroxy
substituted
deoxyfortimicin
epi
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495314A
Other languages
English (en)
Other versions
ES495314A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8107251A1 publication Critical patent/ES8107251A1/es
Publication of ES495314A0 publication Critical patent/ES495314A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE 1-EPI-2-DESOXIFORTIMICINA B DE FORMULA (I), DONDE R1 ES HIDROGENO O ALQUILO INFERIOR, R2 ES ALQUILO, AMINOALQUILO, DIAMINOALQUILO INFERIOR U OTROS, EXCEPTUANDO HIDROGENO, GLICILO, FORMILGLICILO Y HIDANTOILO. LA 1-EPI-2-DESOXI-2-OXO-TETRA-N-BENCILOXICARBONIL-FORTIMICINA A SE REDUCE CON BOROHIDRURO SODICO. LA 1,2-DI-EPI-TETRA-N-FORTIMICINA A RESULTANTE SE 2-DESOXIGENA POR TRATAMIENTO CON TIOCARBONILDIIMIDAZOL. EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON TRI-N-BUTILESTANNANO Y SE ELIMINAN LOS GRUPOS PROTECTORES. OPCIONALMENTE, SE PREPARAN LAS SALES DE ADICION DE ACIDO DEL COMPUESTO DURANTE EL PROCESO DE AISLAMIENTO Y PURIFICACION FINALES O POR REACCION INDEPENDIENTE DE LA BASE LIBRE CON UN ACIDO ADECUADO. SE USAN COMO ANTIBIOTICOS. *FORMULA*
ES495314A 1979-09-26 1980-09-24 Un procedimiento para la preparacion de una 1- epi-2-dexoxifortimicina. Granted ES495314A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/079,146 US4282211A (en) 1979-09-26 1979-09-26 1-Epi-2-deoxyfortimicin B and derivatives

Publications (2)

Publication Number Publication Date
ES8107251A1 true ES8107251A1 (es) 1981-10-01
ES495314A0 ES495314A0 (es) 1981-10-01

Family

ID=22148735

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495314A Granted ES495314A0 (es) 1979-09-26 1980-09-24 Un procedimiento para la preparacion de una 1- epi-2-dexoxifortimicina.

Country Status (9)

Country Link
US (1) US4282211A (es)
JP (1) JPS579777A (es)
AU (1) AU6199080A (es)
BE (1) BE885403A (es)
DE (1) DE3036237A1 (es)
ES (1) ES495314A0 (es)
FR (1) FR2465746A1 (es)
GB (1) GB2059957A (es)
GR (1) GR70197B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56138180A (en) * 1980-03-28 1981-10-28 Microbial Chem Res Found Di-n6',o3-demethylistamycin a and its preparation
JPS58213774A (ja) * 1982-06-04 1983-12-12 Kowa Co 新規アミノ配糖体
US5562219A (en) * 1994-09-22 1996-10-08 Valois, S.A. Device for attaching a dispenser member to a receptacle

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192867A (en) * 1977-12-21 1980-03-11 Abbott Laboratories 2-Deoxyfortimicin A, 4-N-alkyl and 4-N-acyl-2-deoxyfortimicin B derivatives
US4176178A (en) * 1977-12-21 1979-11-27 Abbott Laboratories 2-Deoxy-2'-N-acyl and alkyl fortimicins A and B
US4169198A (en) * 1977-12-21 1979-09-25 Abbott Laboratories 2-Deoxyfortimicin B

Also Published As

Publication number Publication date
DE3036237A1 (de) 1981-04-16
BE885403A (fr) 1981-03-25
ES495314A0 (es) 1981-10-01
GR70197B (es) 1982-08-31
AU6199080A (en) 1981-04-02
GB2059957A (en) 1981-04-29
US4282211A (en) 1981-08-04
JPS579777A (en) 1982-01-19
FR2465746A1 (fr) 1981-03-27

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