[go: up one dir, main page]

ES8105729A1 - Procedimiento para la preparacion de derivados de n-fe- noxialcohilpiperidina - Google Patents

Procedimiento para la preparacion de derivados de n-fe- noxialcohilpiperidina

Info

Publication number
ES8105729A1
ES8105729A1 ES495412A ES495412A ES8105729A1 ES 8105729 A1 ES8105729 A1 ES 8105729A1 ES 495412 A ES495412 A ES 495412A ES 495412 A ES495412 A ES 495412A ES 8105729 A1 ES8105729 A1 ES 8105729A1
Authority
ES
Spain
Prior art keywords
formula
derivatives
compounds
compound
phenoxyalkylpiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495412A
Other languages
English (en)
Other versions
ES495412A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES8105729A1 publication Critical patent/ES8105729A1/es
Publication of ES495412A0 publication Critical patent/ES495412A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBRENCION DE DERIVADOS DE N-FENOXIALCOHILPIPERIDINA DE FORMULA (I) Y DE SUS SALES FARMACOLOGICAMENTE COMPATIBLES, EN LA QUE R1, R2, A, B Y X PUEDEN SER VARIOS TIPOS DE RADICALES. SE HACE REACCIONAR, SOMETIENDOLO A REFLUJO, UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA Y1-A-Y2, EN LAS QUE Y1 E Y2 SON RADICALES REACTIVOS Y A, R1 Y X SON LOS MISMOS QUE EN LA FORMULA (I), EN MEDIO ALCOHOLICO ALCALINO. A CONTINUACION SE AÑADE UN COMPUESTO DE FORMULA (III), EN LA QUE B Y R2 SON LOS MISMOS QUE EN LA FORMULA (I) Y CONTINUA EL CALENTAMIENTO A REFLUJO DURANTE VARIAS HORAS. SE CONCENTRA, EXTRAE CON UN DISOLVENTE ORGANICO, SE LAVA LA DISOLUCION CON DISOLUCION ACUOSA ALCALINA Y SE CONCENTRA POR DESTILACION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTIALERGICA, ANTIEDEMATOSA Y ANTIFLOGISTICA.
ES495412A 1979-09-28 1980-09-26 Procedimiento para la preparacion de derivados de n-fe- noxialcohilpiperidina Granted ES495412A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792939292 DE2939292A1 (de) 1979-09-28 1979-09-28 N-phenoxyalkylpiperidin-derivate, verfahrenn zu deren herstellung sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8105729A1 true ES8105729A1 (es) 1981-06-16
ES495412A0 ES495412A0 (es) 1981-06-16

Family

ID=6082088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495412A Granted ES495412A0 (es) 1979-09-28 1980-09-26 Procedimiento para la preparacion de derivados de n-fe- noxialcohilpiperidina

Country Status (10)

Country Link
US (1) US4348401A (es)
EP (1) EP0026876B1 (es)
JP (1) JPS5668669A (es)
AT (1) ATE2519T1 (es)
CA (1) CA1139759A (es)
CS (1) CS219950B2 (es)
DD (1) DD153117A5 (es)
DE (2) DE2939292A1 (es)
ES (1) ES495412A0 (es)
IL (1) IL61114A0 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209271A1 (de) * 1982-03-13 1983-09-15 Boehringer Mannheim Gmbh, 6800 Mannheim Bicyclische phenolether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
FR2681319B1 (fr) * 1991-09-12 1995-02-17 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents
HU215397B (hu) * 1994-08-29 1998-12-28 Richter Gedeon Vegyészeti Gyár Rt. (Piperidino-alkil)-aril-éterek, ezeket tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
WO2003076395A1 (en) * 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
WO2003076400A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. New inhibitors of histone deacetylase
ES2307909T3 (es) * 2002-03-13 2008-12-01 Janssen Pharmaceutica Nv Derivados de piperazinil, piperidinil y morfolinil como nuevos inhidbidores de la histona deacetilasa.
NZ552865A (en) 2004-07-28 2009-09-25 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
EP1867332B1 (en) * 2005-04-07 2011-08-24 Toyama Chemical Co., Ltd. Pharmaceutical composition and method using antifungal agent in combination
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
CA2631874C (en) * 2006-01-19 2014-11-18 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
ES2327972T3 (es) * 2006-01-19 2009-11-05 Janssen Pharmaceutica, N.V. Derivados de aminofenil como nuevos inhibidores de histona deacetilasa.
EP1979326B1 (en) 2006-01-19 2012-10-03 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JP5137849B2 (ja) * 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体
EP2865381A1 (en) 2006-05-18 2015-04-29 Pharmacyclics, Inc. ITK inhibitors for treating blood cell malignancies
KR102077864B1 (ko) 2012-08-01 2020-02-14 쇼와 덴코 패키징 가부시키가이샤 내용물 부착 방지 덮개재

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255196A (en) * 1966-06-07 Phenoxyalkyl piperidine derivatives
CH426811A (fr) * 1962-02-28 1966-12-31 Rhone Poulenc Sa Procédé de préparation de nouveaux dérivés de la pipéridine
US3691176A (en) * 1970-05-25 1972-09-12 Abbott Lab 1-(4-fluorophenoxypropyl)-4-anilino-piperidines
DE2341376A1 (de) * 1972-08-24 1974-03-07 Ciba Geigy Ag Piperidin-derivate und verfahren zu ihrer herstellung
GB1533383A (en) * 1974-11-15 1978-11-22 Science Union & Cie Arylethers and heterocyclic ethers processes for their preparation and pharmaceutical compositions containing them
US4027028A (en) * 1975-11-10 1977-05-31 Science Union Et Cie Arylethers and pharmaceutical compositions
DE2737630A1 (de) * 1977-08-20 1979-03-01 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DE2939292A1 (de) 1981-04-09
IL61114A0 (en) 1980-11-30
DE3062052D1 (en) 1983-03-24
EP0026876B1 (de) 1983-02-16
US4348401A (en) 1982-09-07
ATE2519T1 (de) 1983-03-15
EP0026876A1 (de) 1981-04-15
CA1139759A (en) 1983-01-18
JPS5668669A (en) 1981-06-09
CS219950B2 (en) 1983-03-25
ES495412A0 (es) 1981-06-16
DD153117A5 (de) 1981-12-23

Similar Documents

Publication Publication Date Title
ES8105729A1 (es) Procedimiento para la preparacion de derivados de n-fe- noxialcohilpiperidina
DE69405864D1 (de) Verfahren zur Herstellung von quaternären Diestern
ES8605791A1 (es) Un procedimiento para la preparacion de derivados de imida- zodiacepina
ES8400415A1 (es) "un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina".
ES8600305A1 (es) Procedimiento de preparar compuestos beta-lactamicos
ES8504128A1 (es) Procedimiento de preparar compuestos antiinflamatorios y anti-alergicos
ES8606879A1 (es) Un procedimiento para la preparacion de derivados esteroida-les
ES8704872A1 (es) Un procedimiento para preparar aril-hidroxamatos
ES8601878A1 (es) Procedimiento para preparar nuevas 1-bencil-aminoalquil-pi- rrolidinonas
ES8600211A1 (es) Un procedimiento para la preparacion de nuevos derivados arilfenilicos
ES8506615A1 (es) Un procedimiento para la preparacion de carboxamidas
SE8106125L (sv) 4,5-polymetylen-4-isotiazolin-3-oner, sett for framstellning derav och anvendning derav som baktericida och fungicida medel
ES8801617A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
ES8201572A1 (es) Procedimiento de preparar derivados propanolaminicos
ES8201583A1 (es) Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES8305755A1 (es) Procedimiento para preparar derivados de pirimidona.
ES8303427A1 (es) "un procedimiento para preparar compuestos de cefem".
ES8507536A1 (es) Un procedimiento para la preparacion de estimulantes cardiacos de quinazolinas.
ES8306137A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
ES8301883A1 (es) Procedimiento para la preparacion de derivados de ciclohexe-no
ES8506707A1 (es) Un derivado de acido tiazolilacetico
ES8304976A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
ES8702390A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina
ES8504792A1 (es) Un procedimiento para preparar derivados de pirimidina
ES8204415A1 (es) Un procedimiento para la preparacion de derivados de carboximidamida.