ES557506A0 - Un procedimiento para preparar relaxina humana o sus analogos - Google Patents

Un procedimiento para preparar relaxina humana o sus analogos

Info

Publication number: ES557506A0
Authority: ES; Spain
Prior art keywords: analogs; procedure; human relaxin; preparing human; preparing
Prior art date: 1982-08-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES557506A

Other languages

English (en)

Other versions

ES8801671A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Florey Institute of Neuroscience and Mental Health

Original Assignee

Howard Florey Institute of Experimental Physiology and Medicine

Florey Institute of Neuroscience and Mental Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-12

Filing date

1987-04-15

Publication date

1988-02-16

1987-04-15 Application filed by Howard Florey Institute of Experimental Physiology and Medicine, Florey Institute of Neuroscience and Mental Health filed Critical Howard Florey Institute of Experimental Physiology and Medicine

1988-02-16 Publication of ES557506A0 publication Critical patent/ES557506A0/es

1988-02-16 Publication of ES8801671A1 publication Critical patent/ES8801671A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 3
BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

ES557506A 1982-08-12 1987-04-15 Un procedimiento para preparar relaxina humana o sus analogos Expired ES8801671A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPF535282		1982-08-12

Publications (2)

Publication Number	Publication Date
ES557506A0 true ES557506A0 (es)	1988-02-16
ES8801671A1 ES8801671A1 (es)	1988-02-16

Family

ID=3769689

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
ES524885A Expired ES8603579A1 (es)	1982-08-12	1983-08-11	Un procedimiento para producir un vector de transferencia de adn.
ES540886A Expired ES8802160A1 (es)	1982-08-12	1985-03-01	Un procedimiento para aislar un gen de relaxina cromosomica de un ser humano o de otro primate o una especie afin
ES550943A Expired ES8802394A1 (es)	1982-08-12	1986-01-16	Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana.
ES557505A Expired ES8801676A1 (es)	1982-08-12	1987-04-15	Un procedimiento para preparar relaxina humana o sus analogos
ES557506A Expired ES8801671A1 (es)	1982-08-12	1987-04-15	Un procedimiento para preparar relaxina humana o sus analogos

Family Applications Before (4)

Application Number	Title	Priority Date	Filing Date
ES524885A Expired ES8603579A1 (es)	1982-08-12	1983-08-11	Un procedimiento para producir un vector de transferencia de adn.
ES540886A Expired ES8802160A1 (es)	1982-08-12	1985-03-01	Un procedimiento para aislar un gen de relaxina cromosomica de un ser humano o de otro primate o una especie afin
ES550943A Expired ES8802394A1 (es)	1982-08-12	1986-01-16	Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana.
ES557505A Expired ES8801676A1 (es)	1982-08-12	1987-04-15	Un procedimiento para preparar relaxina humana o sus analogos

Country Status (14)

Country	Link
US (1)	US4871670A (es)
EP (2)	EP0287820B1 (es)
JP (3)	JP2537477B2 (es)
KR (1)	KR930003515B1 (es)
AT (1)	ATE78042T1 (es)
CA (1)	CA1340542C (es)
DE (1)	DE3382117D1 (es)
DK (2)	DK171827B1 (es)
ES (5)	ES8603579A1 (es)
HU (1)	HU197350B (es)
IE (1)	IE58682B1 (es)
IL (1)	IL69469A (es)
NZ (1)	NZ205241A (es)
ZA (1)	ZA835963B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320953A (en) *	1982-08-12	1994-06-14	Howard Florey Institute Of Experimental Physiology And Medicine	Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
NZ206534A (en) *	1982-12-13	1988-05-30	Florey Howard Inst	Molecular cloning and characterisation of gene sequence coding for human relaxin
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
WO1989007945A1 (en) *	1988-02-26	1989-09-08	Genentech, Inc.	Human relaxin formulation
JP2857684B2 (ja) *	1989-05-04	1999-02-17	ジェネンテク，インコーポレイテッド	ヒトリラキシンの単離のための方法および組成物
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1995000645A2 (en) *	1993-06-21	1995-01-05	Genentech, Inc.	Process for producing relaxin
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
US20070021360A1 (en) *	2001-04-24	2007-01-25	Nyce Jonathan W	Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
AU2002324727A1 (en) *	2001-08-17	2003-03-03	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian relaxin receptors
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
JP4836942B2 (ja) *	2004-04-30	2011-12-14	コーセラ，インコーポレイテッド	リラキシンの調節による胎仔の発育の制御のための方法および組成物
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US8389475B2 (en) *	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
SMT201900495T1 (it)	2010-08-17	2019-11-13	Ambrx Inc	Polipeptidi di relaxina modificati e loro usi
AU2011343813B2 (en) *	2010-12-15	2015-05-21	Takeda Pharmaceutical Company Limited	Eluate collection using conductivity gradient
EP2630964A1 (en)	2012-02-22	2013-08-28	Immundiagnostik AG	Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
WO2015073727A1 (en)	2013-11-13	2015-05-21	Aequus Biopharma, Inc.	Engineered glycoproteins and uses thereof
EP2946788A1 (en)	2014-05-23	2015-11-25	Immundiagnostik AG	Method and composition for treating heart failure with preserved ejection fraction
CN115837014A (zh)	2016-05-18	2023-03-24	摩登纳特斯有限公司	编码松弛素的多核苷酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
NZ206534A (en) *	1982-12-13	1988-05-30	Florey Howard Inst	Molecular cloning and characterisation of gene sequence coding for human relaxin

1983
- 1983-08-11 EP EP88104503A patent/EP0287820B1/en not_active Expired - Lifetime
- 1983-08-11 ES ES524885A patent/ES8603579A1/es not_active Expired
- 1983-08-11 DK DK366483A patent/DK171827B1/da not_active IP Right Cessation
- 1983-08-11 EP EP83304662A patent/EP0101309B1/en not_active Expired - Lifetime
- 1983-08-11 IL IL69469A patent/IL69469A/xx not_active IP Right Cessation
- 1983-08-11 DE DE8383304662T patent/DE3382117D1/de not_active Expired - Lifetime
- 1983-08-11 AT AT88104503T patent/ATE78042T1/de not_active IP Right Cessation
- 1983-08-12 JP JP58146766A patent/JP2537477B2/ja not_active Expired - Lifetime
- 1983-08-12 IE IE190983A patent/IE58682B1/en not_active IP Right Cessation
- 1983-08-12 HU HU832842A patent/HU197350B/hu unknown
- 1983-08-12 ZA ZA835963A patent/ZA835963B/xx unknown
- 1983-08-12 KR KR1019830003783A patent/KR930003515B1/ko not_active Expired - Lifetime
- 1983-08-12 CA CA000434438A patent/CA1340542C/en not_active Expired - Fee Related
- 1983-08-12 NZ NZ205241A patent/NZ205241A/xx unknown
1985
- 1985-03-01 ES ES540886A patent/ES8802160A1/es not_active Expired
1986
- 1986-01-16 ES ES550943A patent/ES8802394A1/es not_active Expired
- 1986-05-12 US US06/863,819 patent/US4871670A/en not_active Expired - Lifetime
1987
- 1987-04-15 ES ES557505A patent/ES8801676A1/es not_active Expired
- 1987-04-15 ES ES557506A patent/ES8801671A1/es not_active Expired
1992
- 1992-12-28 DK DK156592A patent/DK171683B1/da not_active IP Right Cessation
1993
- 1993-03-19 JP JP5060138A patent/JP2670001B2/ja not_active Expired - Lifetime
1995
- 1995-01-05 JP JP7000236A patent/JP2892596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK366483D0 (da)	1983-08-11
EP0101309B1 (en)	1991-01-16
IL69469A0 (en)	1983-11-30
IL69469A (en)	1991-06-10
ZA835963B (en)	1984-04-25
DK171827B1 (da)	1997-06-23
HU197350B (en)	1989-03-28
ES524885A0 (es)	1985-12-16
DE3382117D1 (de)	1991-02-21
KR930003515B1 (ko)	1993-05-01
DK156592D0 (da)	1992-12-28
KR840005739A (ko)	1984-11-16
NZ205241A (en)	1991-01-29
IE831909L (en)	1984-02-12
DK366483A (da)	1984-02-13
ATE78042T1 (de)	1992-07-15
ES8802160A1 (es)	1988-04-01
JPH0690780A (ja)	1994-04-05
ES540886A0 (es)	1988-04-01
EP0101309A2 (en)	1984-02-22
DK171683B1 (da)	1997-03-10
JP2892596B2 (ja)	1999-05-17
JP2537477B2 (ja)	1996-09-25
JPS5985292A (ja)	1984-05-17
US4871670A (en)	1989-10-03
CA1340542C (en)	1999-05-18
ES8802394A1 (es)	1988-05-16
IE58682B1 (en)	1993-11-03
EP0287820B1 (en)	1992-07-08
ES8801671A1 (es)	1988-02-16
EP0101309A3 (en)	1984-12-27
ES8801676A1 (es)	1988-02-16
ES557505A0 (es)	1988-02-16
EP0287820A1 (en)	1988-10-26
ES8603579A1 (es)	1985-12-16
JP2670001B2 (ja)	1997-10-29
ES550943A0 (es)	1988-05-16
DK156592A (da)	1992-12-28
JPH07215998A (ja)	1995-08-15

Publication	Publication Date	Title
ES557505A0 (es)	1988-02-16	Un procedimiento para preparar relaxina humana o sus analogos
ES552094A0 (es)	1987-09-01	Un procedimiento para preparar relaxina -h2 humana o uno de sus analogos
ES526524A0 (es)	1985-04-01	Un procedimiento para preparar un complejo inmunogenico que contiene proteinas o peptidos antigenicos
IT8321083A0 (it)	1983-05-13	Analoghi retro-invertiti del pentapeptide potenziante la bradichinina bpp5a e metodi per laloro preparazione.
ES533924A0 (es)	1985-07-01	Procedimiento para preparar proteina de uroquinasa humana bioactiva
ES548617A0 (es)	1986-12-01	Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo
IT8324352A0 (it)	1983-12-23	Analoghi di prostaglandina 7-ossabicicloeptano ammino sostitutivo.
FI896242A7 (fi)	1989-12-22	HIV-ENV-proteiineihin liittyviä synteettisiä peptidejä
IT8419142A0 (it)	1984-01-13	Analoghi retro-invertiti esapeptidici c-terminali della sostanza p.
SE8403377L (sv)	1984-12-28	Nya peptider
ES555737A0 (es)	1987-12-16	Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES2091752T3 (es)	1996-11-16	Medios y procedimiento para la obtencion de un polipeptido de la interleucina-1 alfa humana, recombinante.
DK340288D0 (da)	1988-06-21	Polypeptidanaloger og fremgangsmaade til fremstilling deraf
ES519734A0 (es)	1984-10-01	Un procedimiento para preparar peptidos sinteticos del tipo de las calcitoninas.
IT8367658A0 (it)	1983-06-14	Preparato farmaceutico contenente un frammento del peptide alfa endorfina
DK369888A (da)	1988-07-04	Peptidforbindelser
IT1153100B (it)	1987-01-14	Analoghi retro-invertiti del pentapeptide potenziante la bradichinina bpp 5a
DK652889A (da)	1989-12-21	Fremgangsmaade til fremstilling af et protein eller polypeptid
DK652089D0 (da)	1989-12-21	Syntetiske peptider med slaegtskab til hiv-env-protein

Legal Events

Date	Code	Title	Description
2006-11-16	FD1A	Patent lapsed	Effective date: 20041209