DK156592A - Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin - Google Patents

Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin Download PDF

Info

Publication number: DK156592A
Authority: DK; Denmark
Prior art keywords: relaxin; human; chains; preeprorelaxin; prorelaxin
Prior art date: 1982-08-12

Application number

DK156592A

Other languages

English (en)

Other versions

DK171683B1 (da

DK156592D0 (da

Inventor

Peter John Hudson

John Shine

Hugh David Niall

Geoffrey William Tregear

Original Assignee

Florey Howard Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-12

Filing date

1992-12-28

Publication date

1992-12-28

1992-12-28 Application filed by Florey Howard Inst filed Critical Florey Howard Inst

1992-12-28 Publication of DK156592A publication Critical patent/DK156592A/da

1992-12-28 Publication of DK156592D0 publication Critical patent/DK156592D0/da

1997-03-10 Application granted granted Critical

1997-03-10 Publication of DK171683B1 publication Critical patent/DK171683B1/da

Links

238000000034 method Methods 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
101001091094 Homo sapiens Prorelaxin H1 Proteins 0.000 title 1
102000003743 Relaxin Human genes 0.000 title 1
108090000103 Relaxin Proteins 0.000 title 1
238000013329 compounding Methods 0.000 title 1
102000049117 human RLN1 Human genes 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical class C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

DK156592A 1982-08-12 1992-12-28 Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog DK171683B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPF535282		1982-08-12
AUPF535282		1982-08-12

Publications (3)

Publication Number	Publication Date
DK156592A true DK156592A (da)	1992-12-28
DK156592D0 DK156592D0 (da)	1992-12-28
DK171683B1 DK171683B1 (da)	1997-03-10

Family

ID=3769689

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK366483A DK171827B1 (da)	1982-08-12	1983-08-11	Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle
DK156592A DK171683B1 (da)	1982-08-12	1992-12-28	Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK366483A DK171827B1 (da)	1982-08-12	1983-08-11	Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle

Country Status (14)

Country	Link
US (1)	US4871670A (da)
EP (2)	EP0101309B1 (da)
JP (3)	JP2537477B2 (da)
KR (1)	KR930003515B1 (da)
AT (1)	ATE78042T1 (da)
CA (1)	CA1340542C (da)
DE (1)	DE3382117D1 (da)
DK (2)	DK171827B1 (da)
ES (5)	ES8603579A1 (da)
HU (1)	HU197350B (da)
IE (1)	IE58682B1 (da)
IL (1)	IL69469A (da)
NZ (1)	NZ205241A (da)
ZA (1)	ZA835963B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320953A (en) *	1982-08-12	1994-06-14	Howard Florey Institute Of Experimental Physiology And Medicine	Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
NZ206534A (en) *	1982-12-13	1988-05-30	Florey Howard Inst	Molecular cloning and characterisation of gene sequence coding for human relaxin
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
EP0407401B1 (en) *	1988-02-26	1993-04-21	Genentech, Inc.	Human relaxin formulation
JP2857684B2 (ja) *	1989-05-04	1999-02-17	ジェネンテク，インコーポレイテッド	ヒトリラキシンの単離のための方法および組成物
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1995000645A2 (en) *	1993-06-21	1995-01-05	Genentech, Inc.	Process for producing relaxin
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
WO2002085308A2 (en) *	2001-04-24	2002-10-31	Epigenesis Pharmaceuticals, Inc.	Antisense and anti-inflammatory based compositions to treat respiratory disorders
AU2002324727A1 (en) *	2001-08-17	2003-03-03	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian relaxin receptors
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
AU2005247332A1 (en) *	2004-04-30	2005-12-08	Corthera, Inc.	Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US8389475B2 (en) *	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
AU2011291943B2 (en)	2010-08-17	2015-01-22	Ambrx, Inc.	Modified relaxin polypeptides and their uses
WO2012082933A1 (en) *	2010-12-15	2012-06-21	Baxter International, Inc.	Eluate collection using conductivity gradient
EP2630964A1 (en)	2012-02-22	2013-08-28	Immundiagnostik AG	Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
US20160296632A1 (en)	2013-11-13	2016-10-13	Aequus Biopharma, Inc.	Engineered glycoproteins and uses thereof
EP2946788A1 (en)	2014-05-23	2015-11-25	Immundiagnostik AG	Method and composition for treating heart failure with preserved ejection fraction
JP7088911B2 (ja)	2016-05-18	2022-06-21	モデルナティエックスインコーポレイテッド	リラキシンをコードするポリヌクレオチド

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
NZ206534A (en) *	1982-12-13	1988-05-30	Florey Howard Inst	Molecular cloning and characterisation of gene sequence coding for human relaxin

1983
- 1983-08-11 IL IL69469A patent/IL69469A/xx not_active IP Right Cessation
- 1983-08-11 EP EP83304662A patent/EP0101309B1/en not_active Expired - Lifetime
- 1983-08-11 DK DK366483A patent/DK171827B1/da not_active IP Right Cessation
- 1983-08-11 EP EP88104503A patent/EP0287820B1/en not_active Expired - Lifetime
- 1983-08-11 AT AT88104503T patent/ATE78042T1/de not_active IP Right Cessation
- 1983-08-11 DE DE8383304662T patent/DE3382117D1/de not_active Expired - Lifetime
- 1983-08-11 ES ES524885A patent/ES8603579A1/es not_active Expired
- 1983-08-12 IE IE190983A patent/IE58682B1/en not_active IP Right Cessation
- 1983-08-12 JP JP58146766A patent/JP2537477B2/ja not_active Expired - Lifetime
- 1983-08-12 HU HU832842A patent/HU197350B/hu unknown
- 1983-08-12 NZ NZ205241A patent/NZ205241A/xx unknown
- 1983-08-12 ZA ZA835963A patent/ZA835963B/xx unknown
- 1983-08-12 CA CA000434438A patent/CA1340542C/en not_active Expired - Fee Related
- 1983-08-12 KR KR1019830003783A patent/KR930003515B1/ko not_active Expired - Lifetime
1985
- 1985-03-01 ES ES540886A patent/ES8802160A1/es not_active Expired
1986
- 1986-01-16 ES ES550943A patent/ES8802394A1/es not_active Expired
- 1986-05-12 US US06/863,819 patent/US4871670A/en not_active Expired - Lifetime
1987
- 1987-04-15 ES ES557506A patent/ES8801671A1/es not_active Expired
- 1987-04-15 ES ES557505A patent/ES8801676A1/es not_active Expired
1992
- 1992-12-28 DK DK156592A patent/DK171683B1/da not_active IP Right Cessation
1993
- 1993-03-19 JP JP5060138A patent/JP2670001B2/ja not_active Expired - Lifetime
1995
- 1995-01-05 JP JP7000236A patent/JP2892596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES540886A0 (es)	1988-04-01
ES550943A0 (es)	1988-05-16
KR840005739A (ko)	1984-11-16
DE3382117D1 (de)	1991-02-21
NZ205241A (en)	1991-01-29
ATE78042T1 (de)	1992-07-15
ES8802394A1 (es)	1988-05-16
KR930003515B1 (ko)	1993-05-01
ES8801671A1 (es)	1988-02-16
ES557506A0 (es)	1988-02-16
JP2892596B2 (ja)	1999-05-17
EP0287820A1 (en)	1988-10-26
ES8801676A1 (es)	1988-02-16
ZA835963B (en)	1984-04-25
IE831909L (en)	1984-02-12
JP2537477B2 (ja)	1996-09-25
DK171827B1 (da)	1997-06-23
DK171683B1 (da)	1997-03-10
CA1340542C (en)	1999-05-18
US4871670A (en)	1989-10-03
IL69469A (en)	1991-06-10
EP0101309A2 (en)	1984-02-22
JPH07215998A (ja)	1995-08-15
JP2670001B2 (ja)	1997-10-29
EP0287820B1 (en)	1992-07-08
ES524885A0 (es)	1985-12-16
JPH0690780A (ja)	1994-04-05
ES8603579A1 (es)	1985-12-16
IE58682B1 (en)	1993-11-03
ES557505A0 (es)	1988-02-16
IL69469A0 (en)	1983-11-30
DK366483D0 (da)	1983-08-11
DK156592D0 (da)	1992-12-28
JPS5985292A (ja)	1984-05-17
EP0101309B1 (en)	1991-01-16
EP0101309A3 (en)	1984-12-27
DK366483A (da)	1984-02-13
ES8802160A1 (es)	1988-04-01
HU197350B (en)	1989-03-28

Publication	Publication Date	Title
DK156592A (da)	1992-12-28	Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin
DK143492A (da)	1992-11-30	Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet
NO821111L (no)	1982-10-04	Radioaktivt merkede peptider
CY1105597T1 (el)	2010-07-28	Ανοσοθεραπευτικες μεθοδοι χρησιμοποιωντας επιτοπους των wt-1 και gata-1
DK175843B1 (da)	2005-03-29	Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet
ES548617A0 (es)	1986-12-01	Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo
ATE432287T1 (de)	2009-06-15	Peptidfragmente mit den zelltod verhindernder aktivität
DK288789A (da)	1989-12-15	Peptider og syreadditionssalte deraf, deres fremstilling og anvendelse
DK262986A (da)	1986-12-07	Peptidmateriale med thymushumoral aktivitet
NO854903L (no)	1986-02-04	Peptidvaksine eller -diagnosemiddel, samt polypeptid for slik anvendelse.
ATE112290T1 (de)	1994-10-15	Peptiden von retinblastoma gen produkten und antikoerper dagegen.
NO864742D0 (no)	1986-11-26	Dna-sekvens som koder for human vevsplasminogenaktivator, rekombinant dna-sekvens, vertcelle transformert med denne samt fremgangsmaate for fremstilling av plasminogenaktivatoren.
NO893572L (no)	1989-09-05	Lunge-overflateaktivt protein og beslektet polypeptid.
ATE98990T1 (de)	1994-01-15	Menschlicher prourokinase aehnliches polypeptid.
ATE75255T1 (de)	1992-05-15	Peptid und dafuer kodierendes gen.

Legal Events

Date	Code	Title
1992-12-28	A0	Application filed
2001-11-12	PUP	Patent expired
2003-09-01	PUP	Patent expired