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ES557344A0 - Procedimiento para prepara nuevos acidos tieno-triazolo-1,4-diazepino-2-carboxilicos - Google Patents

Procedimiento para prepara nuevos acidos tieno-triazolo-1,4-diazepino-2-carboxilicos

Info

Publication number
ES557344A0
ES557344A0 ES557344A ES557344A ES557344A0 ES 557344 A0 ES557344 A0 ES 557344A0 ES 557344 A ES557344 A ES 557344A ES 557344 A ES557344 A ES 557344A ES 557344 A0 ES557344 A0 ES 557344A0
Authority
ES
Spain
Prior art keywords
carbon atoms
halogen
diazepino
triazolo
carboxilicos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES557344A
Other languages
English (en)
Other versions
ES8802523A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES557344A0 publication Critical patent/ES557344A0/es
Publication of ES8802523A1 publication Critical patent/ES8802523A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES557344A 1985-01-25 1987-01-21 Procedimiento para prepara nuevos acidos tieno-triazolo-1,4-diazepino-2-carboxilicos Expired ES8802523A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853502392 DE3502392A1 (de) 1985-01-25 1985-01-25 Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
ES557344A0 true ES557344A0 (es) 1988-07-16
ES8802523A1 ES8802523A1 (es) 1988-07-16

Family

ID=6260695

Family Applications (3)

Application Number Title Priority Date Filing Date
ES551198A Expired ES8704949A1 (es) 1985-01-25 1986-01-24 Procedimiento para preparar nuevas amidas de acidos tieno-triazolo-1,4-diazepino-2-carboxilicos
ES557343A Expired ES8802426A1 (es) 1985-01-25 1987-01-21 Procedimiento para prepara nuevas amidas de acidos tieno-triazolo-1,4-diazepino-2-carboxilicos
ES557344A Expired ES8802523A1 (es) 1985-01-25 1987-01-21 Procedimiento para prepara nuevos acidos tieno-triazolo-1,4-diazepino-2-carboxilicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES551198A Expired ES8704949A1 (es) 1985-01-25 1986-01-24 Procedimiento para preparar nuevas amidas de acidos tieno-triazolo-1,4-diazepino-2-carboxilicos
ES557343A Expired ES8802426A1 (es) 1985-01-25 1987-01-21 Procedimiento para prepara nuevas amidas de acidos tieno-triazolo-1,4-diazepino-2-carboxilicos

Country Status (28)

Country Link
US (3) US4968794A (es)
EP (1) EP0194416B1 (es)
JP (2) JPH0633278B2 (es)
KR (1) KR920010711B1 (es)
AT (1) ATE42556T1 (es)
AU (1) AU584663B2 (es)
CA (1) CA1269373A (es)
CS (1) CS254992B2 (es)
CZ (1) CZ410791A3 (es)
DD (3) DD263063A5 (es)
DE (2) DE3502392A1 (es)
DK (2) DK165323C (es)
ES (3) ES8704949A1 (es)
FI (1) FI86851C (es)
GR (1) GR860189B (es)
HK (1) HK75792A (es)
HU (2) HU193624B (es)
IE (1) IE58728B1 (es)
IL (1) IL77702A (es)
MX (1) MX9203258A (es)
NO (2) NO164029C (es)
NZ (1) NZ214926A (es)
PL (1) PL144948B1 (es)
PT (1) PT81898B (es)
SG (1) SG44292G (es)
SU (1) SU1402265A3 (es)
YU (2) YU44280B (es)
ZA (1) ZA86542B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg Neue 1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3745135C2 (de) * 1986-10-21 1999-05-12 Korth Ruth Verwendung von hydrophilen Triazolothieno-diazepinen zur Behandlung von Arteriosklerose
EP0268242B1 (en) * 1986-11-17 1992-03-18 Yoshitomi Pharmaceutical Industries, Ltd. Paf-antagonistic thienotriazolodiazepine compounds and pharmaceutical uses thereof
DE3725130C2 (de) * 1987-07-29 1996-12-12 Boehringer Ingelheim Kg Tritium-oder ·1··4·C-markiertes 4-(2-Chlorphenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanon-1-yl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin, Verfahren zu deren Herstellung und deren Verwendung als Radiorezeptorassay sowie zu diagnostischen Zwecken
EP0540767B9 (en) * 1991-11-04 2004-12-22 Korth, Ruth-Maria, Dr. med Treatment and prevention of mental diseases mediated by elevated lyso paf levels with paf antagonists
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (en) * 1988-01-30 1993-11-30 Minoru Moriwaki Thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0338993A1 (en) * 1988-04-21 1989-10-25 Sandoz Ag 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines
ATE84724T1 (de) * 1988-04-27 1993-02-15 Schering Corp Gewisse paf-antagonist/antihistamin-mischungen und verfahren.
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
CA1322367C (en) * 1988-05-17 1993-09-21 Yoshitomi Pharmaceutical Industries Ltd. Thienotriazolodiazepine compounds and pharmaceutical uses thereof
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5382579A (en) * 1988-10-31 1995-01-17 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5304553A (en) * 1988-10-31 1994-04-19 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
US5468740A (en) * 1988-10-31 1995-11-21 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
FI95708C (fi) 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
RU2117670C1 (ru) * 1988-10-31 1998-08-20 Эйсай Ко., Лтд. Производные триазоло[1,4]диазепина и способы их получения
EP0387613A1 (de) * 1989-03-03 1990-09-19 Boehringer Ingelheim Kg Neue Thienodiazepine
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
CA2083611A1 (en) * 1990-05-31 1991-12-01 David Frederick Woodward Use of platelet activating factor antagonists as anti-pruritic agents
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4128579A1 (de) * 1991-08-28 1993-03-04 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
TW219935B (es) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
DE4200619A1 (de) * 1992-01-13 1993-07-15 Boehringer Ingelheim Kg Verwendung von 4-(2-chlorphenyl)-9-methyl-2-/3(4-morpholinyl)-3-propanon-1-yl/-6h-thieno-/3,2-f//1,2,4/ triazolo/4,3-a//1,4/diazepin zur behandlung der dysmenorrhes
GB9207645D0 (en) * 1992-04-08 1992-05-27 Smithkline Beecham Corp Methods
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
HUT77348A (hu) * 1994-11-08 1998-03-30 Takeda Chemical Industries, Ltd. Tienopiridin- és tienopirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
EP0995752A4 (en) 1997-06-25 2001-08-16 Nikken Chemicals Co Ltd TIRAZOLO-1,4-DIAZEPINE DERIVATIVES AND MEDICAL PREPARATION CONTAINING THEM
CN1812983A (zh) 2003-05-30 2006-08-02 兰贝克赛实验室有限公司 取代的吡咯衍生物及其作为hmg-co抑制剂的用途
US7223167B2 (en) * 2005-04-01 2007-05-29 Cnh America Llc Anti-wind wiper with adjustable extension
SG166829A1 (en) 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US9638493B2 (en) 2011-11-26 2017-05-02 Orval E. Bowman Pointing devices, apparatus, systems and methods for high shock environments
IL302769A (en) 2020-11-16 2023-07-01 Boehringer Ingelheim Int Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists
JP2025501761A (ja) 2021-12-22 2025-01-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板活性化因子受容体アンタゴニストとしてのシクロペンタチオフェンカルボキサミド誘導体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12303A (en) * 1973-02-08 1979-01-16 Hoffmann La Roche Thienotriazolodiazepine derivatives
DE2503235A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Neues verfahren zur herstellung von 8-brom-thieno-triazolo-1,4-diazepinen
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
AU518438B2 (en) * 1978-04-26 1981-10-01 Boehringer Ingelheim International Gmbh Substituted 6-aryl-4h-s-triazolo-3,4-c-thieno-2,3-e-1,4-diazepines
AU520063B2 (en) * 1978-07-13 1982-01-14 Boehringer Ingelheim International Gmbh Substituted 4h-s-triazolo(3,4-c)thieno(2,3-e)1,4-diazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
DE3878833T2 (de) * 1987-05-28 1993-06-09 Yoshitomi Pharmaceutical Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US4914096A (en) * 1988-04-21 1990-04-03 Sandoz Pharmaceuticals Corp. 6-aryl-substituted-4H-thieno(2,3-e)(1,2,4)triazolo(3,4-c)(1,4)diazepines

Also Published As

Publication number Publication date
CZ410791A3 (en) 1993-04-14
DD263063A5 (de) 1988-12-21
IE860209L (en) 1986-07-25
JPH0651704B2 (ja) 1994-07-06
NO164029B (no) 1990-05-14
PT81898B (pt) 1988-05-27
US4968794A (en) 1990-11-06
ZA86542B (en) 1987-09-30
DK165323C (da) 1993-03-29
FI860296A0 (fi) 1986-01-22
EP0194416A1 (de) 1986-09-17
SG44292G (en) 1992-09-04
DD265799A5 (de) 1989-03-15
EP0194416B1 (de) 1989-04-26
US5155103A (en) 1992-10-13
CS254992B2 (en) 1988-02-15
FI860296L (fi) 1986-07-26
DE3663028D1 (en) 1989-06-01
ES8802523A1 (es) 1988-07-16
ES8802426A1 (es) 1988-06-01
YU7886A (en) 1987-10-31
DK46292D0 (da) 1992-04-06
DD265899A5 (de) 1989-03-15
HK75792A (en) 1992-10-09
KR920010711B1 (ko) 1992-12-14
IL77702A (en) 1989-02-28
DK36786A (da) 1986-07-26
NO164029C (no) 1990-08-22
FI86851C (fi) 1992-10-26
DE3502392A1 (de) 1986-07-31
PT81898A (de) 1986-02-01
AU584663B2 (en) 1989-06-01
JPH0633278B2 (ja) 1994-05-02
YU44280B (en) 1990-04-30
NO166646C (no) 1991-08-21
ES557343A0 (es) 1988-06-01
DK165323B (da) 1992-11-09
NO166646B (no) 1991-05-13
SU1402265A3 (ru) 1988-06-07
CA1269373A (en) 1990-05-22
US5082839A (en) 1992-01-21
MX9203258A (es) 1992-07-01
GR860189B (en) 1986-05-26
DK36786D0 (da) 1986-01-24
AU5272886A (en) 1986-07-31
PL257602A1 (en) 1987-05-04
HUT40441A (en) 1986-12-28
NO894640L (no) 1986-07-28
FI86851B (fi) 1992-07-15
JPH02191281A (ja) 1990-07-27
IE58728B1 (en) 1993-11-03
JPS61176591A (ja) 1986-08-08
PL144948B1 (en) 1988-07-30
HU193624B (en) 1987-11-30
NZ214926A (en) 1989-04-26
ES551198A0 (es) 1987-04-16
DK46292A (da) 1992-04-06
ES8704949A1 (es) 1987-04-16
NO894640D0 (no) 1989-11-22
YU46049B (sh) 1992-12-21
YU79987A (en) 1988-06-30
NO855260L (no) 1986-07-28
ATE42556T1 (de) 1989-05-15
KR860005822A (ko) 1986-08-13
HU195821B (en) 1988-07-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040410