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ES556101A0 - A PROCEDURE FOR THE PREPARATION OF NEW CARBAZOLONE DERIVATIVES - Google Patents

A PROCEDURE FOR THE PREPARATION OF NEW CARBAZOLONE DERIVATIVES

Info

Publication number
ES556101A0
ES556101A0 ES556101A ES556101A ES556101A0 ES 556101 A0 ES556101 A0 ES 556101A0 ES 556101 A ES556101 A ES 556101A ES 556101 A ES556101 A ES 556101A ES 556101 A0 ES556101 A0 ES 556101A0
Authority
ES
Spain
Prior art keywords
procedure
preparation
new
carbazolone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES556101A
Other languages
Spanish (es)
Other versions
ES8801247A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES556101A0 publication Critical patent/ES556101A0/en
Publication of ES8801247A1 publication Critical patent/ES8801247A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES556101A 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives Expired ES8801247A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES556101A0 true ES556101A0 (en) 1987-12-16
ES8801247A1 ES8801247A1 (en) 1987-12-16

Family

ID=26287221

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES548430A Expired ES8708224A1 (en) 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES556101A Expired ES8801247A1 (en) 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES548430A Expired ES8708224A1 (en) 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE19375046I2 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU88268I2 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

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EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives
EP0385517B1 (en) * 1985-03-14 1993-04-14 BEECHAM GROUP plc Medicaments for the treatment of emesis
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
ES2036587T5 (en) * 1986-11-21 1995-10-16 Glaxo Group Ltd MEDICATIONS FOR THE TREATMENT OR PREVENTION OF WITHDRAWAL SYNDROME.
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
DE3788057T2 (en) * 1986-12-17 1994-03-03 Glaxo Group Ltd Use of heterocyclic compounds for the treatment of depression.
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
IE60991B1 (en) * 1986-12-17 1994-09-07 Glaxo Group Ltd Use of ketone derivatives in the treatment of cognitive disorders
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US4918080A (en) * 1987-04-14 1990-04-17 Glaxo Group Limited Imidazollyl containing ketone derivatives
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DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
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JPH01258673A (en) * 1987-10-22 1989-10-16 Glaxo Group Ltd Ketone derivative
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
JPH0256485A (en) * 1988-04-27 1990-02-26 Glaxo Group Ltd Lactam derivative
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
KR900013959A (en) * 1989-03-13 1990-10-22 원본미기재 γ-carbline or their pharmaceutically acceptable acid addition salts and / or hydrates, and pharmaceutical compositions composed thereof
ATE97803T1 (en) * 1989-04-21 1993-12-15 Sandoz Ag THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
AU2295792A (en) * 1991-06-26 1993-01-25 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
AU683447B2 (en) * 1993-03-08 1997-11-13 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating or preventing cerebrovascular diseases
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GB2325409B (en) * 1994-06-28 1999-02-10 Kenneth Francis Prendergast Pharmaceutical use of ondansetron/cyclodextrin complexes
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US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
CA2371822A1 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
RU2207340C2 (en) * 2001-08-10 2003-06-27 Ципла Лтд. Method for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazole-1-yl)methyl]-4h-carbazole-4-one or its pharmaceutically acceptable salts
MXPA04010846A (en) 2002-04-29 2005-01-25 Biogal Gyogyszergyar Process for preparing 1, 2, 3, 9- tetrahydro -9-methyl -3-[(2 -methyl -1h- imidazol -1-yl) methyl]- 4h-carbazol -4 -one.
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (en) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS.
WO2005108392A2 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
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ES2432618T3 (en) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit
KR101779991B1 (en) 2009-05-20 2017-09-19 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 A kind of ondansetron compound and its preparation method and application
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EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives

Also Published As

Publication number Publication date
ATA20485A (en) 1990-08-15
CA1252793A (en) 1989-04-18
GB2153821A (en) 1985-08-29
KR850005439A (en) 1985-08-26
IL74165A (en) 1988-11-15
GR850219B (en) 1985-05-23
CZ404391A3 (en) 1993-04-14
HU193592B (en) 1987-11-30
SK277923B6 (en) 1995-08-09
LU85743A1 (en) 1986-08-04
LU88268I2 (en) 1994-02-03
GB8501889D0 (en) 1985-02-27
HK33189A (en) 1989-04-28
DK169521B1 (en) 1994-11-21
DK35785D0 (en) 1985-01-25
NL190373C (en) 1994-02-01
GB2153821B (en) 1988-01-20
PT79890A (en) 1985-02-01
NO164025C (en) 1990-08-22
FR2561244A1 (en) 1985-09-20
ES8801247A1 (en) 1987-12-16
DE3502508C2 (en) 1990-05-03
FI850323L (en) 1985-07-26
FI850323A0 (en) 1985-01-25
HUT37784A (en) 1986-02-28
ES539852A0 (en) 1986-07-16
ES8708224A1 (en) 1987-10-01
IT1182150B (en) 1987-09-30
SK404391A3 (en) 1995-08-09
NL940009I1 (en) 1994-07-18
AU3809785A (en) 1985-08-01
SE460359B (en) 1989-10-02
PH22672A (en) 1988-11-14
DE3502508A1 (en) 1985-08-14
ES8609309A1 (en) 1986-07-16
NL940009I2 (en) 1999-05-03
AT392276B (en) 1991-02-25
BE901576A (en) 1985-07-25
PT79890B (en) 1987-02-03
IE57809B1 (en) 1993-04-21
DK35785A (en) 1985-07-26
FI84349C (en) 1991-11-25
ES548430A0 (en) 1987-10-01
SG7089G (en) 1989-06-09
SE8500368D0 (en) 1985-01-25
FI84349B (en) 1991-08-15
KR920003064B1 (en) 1992-04-13
DE19375046I2 (en) 2002-10-10
NL8500202A (en) 1985-08-16
SE8500368L (en) 1985-07-26
AU579132B2 (en) 1988-11-17
IT8547600A0 (en) 1985-01-25
NZ210940A (en) 1989-08-29
CH664152A5 (en) 1988-02-15
NL190373B (en) 1993-09-01
CY1479A (en) 1989-07-21
NO850300L (en) 1985-07-26
FR2561244B1 (en) 1988-03-04
NO164025B (en) 1990-05-14
IE850187L (en) 1985-07-25
NO1994022I1 (en) 1994-11-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071029