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ES548430A0 - A PROCEDURE FOR THE PREPARATION OF NEW CARBAZOLONE DERIVATIVES - Google Patents

A PROCEDURE FOR THE PREPARATION OF NEW CARBAZOLONE DERIVATIVES

Info

Publication number
ES548430A0
ES548430A0 ES548430A ES548430A ES548430A0 ES 548430 A0 ES548430 A0 ES 548430A0 ES 548430 A ES548430 A ES 548430A ES 548430 A ES548430 A ES 548430A ES 548430 A0 ES548430 A0 ES 548430A0
Authority
ES
Spain
Prior art keywords
procedure
preparation
new
carbazolone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES548430A
Other languages
Spanish (es)
Other versions
ES8708224A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES548430A0 publication Critical patent/ES548430A0/en
Publication of ES8708224A1 publication Critical patent/ES8708224A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES548430A 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives Expired ES8708224A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ES548430A0 true ES548430A0 (en) 1987-10-01
ES8708224A1 ES8708224A1 (en) 1987-10-01

Family

ID=26287221

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES548430A Expired ES8708224A1 (en) 1984-01-25 1985-10-31 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
ES556101A Expired ES8801247A1 (en) 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539852A Expired ES8609309A1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES556101A Expired ES8801247A1 (en) 1984-01-25 1986-06-16 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE19375046I2 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK277923B6 (en)

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AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds
DE385517T1 (en) * 1985-03-14 1991-07-25 Beecham Group p.l.c., Brentford, Middlesex MEDICINES FOR TREATING EMERGENCY.
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
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AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
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GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
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US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
AU618520B2 (en) * 1986-12-17 1992-01-02 Glaxo Group Limited Medicaments
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CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
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GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
EP0336759A1 (en) * 1988-04-07 1989-10-11 Glaxo Group Limited Imidazole derivatives
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
EP0392663A1 (en) * 1989-03-13 1990-10-17 Ono Pharmaceutical Co., Ltd. Carboline derivative as a 5-HT3 receptor antagonist
ATE97803T1 (en) * 1989-04-21 1993-12-15 Sandoz Ag THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
WO1993000074A1 (en) * 1991-06-26 1993-01-07 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
HUT68293A (en) * 1993-03-08 1995-06-28 Fujisawa Pharmaceutical Co 5-ht antagonists as acting agent against cerebrovascular deseases
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US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
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US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
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CN1665823A (en) 2002-04-29 2005-09-07 特瓦药厂有限公司 Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one
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WO2005108392A2 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
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CN102458400B (en) 2009-05-20 2014-10-08 国立健康与医学研究所 Serotonin 5-HT3 receptor antagonists for the treatment of focal vestibular dysfunction
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 A kind of ondansetron compound and its preparation method and application
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US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds

Also Published As

Publication number Publication date
NO164025B (en) 1990-05-14
DK35785A (en) 1985-07-26
GR850219B (en) 1985-05-23
DE3502508C2 (en) 1990-05-03
NO850300L (en) 1985-07-26
FR2561244B1 (en) 1988-03-04
NO164025C (en) 1990-08-22
SE8500368D0 (en) 1985-01-25
PH22672A (en) 1988-11-14
FI850323L (en) 1985-07-26
NL190373C (en) 1994-02-01
CH664152A5 (en) 1988-02-15
HUT37784A (en) 1986-02-28
AU579132B2 (en) 1988-11-17
FR2561244A1 (en) 1985-09-20
DE19375046I2 (en) 2002-10-10
NL940009I2 (en) 1999-05-03
ATA20485A (en) 1990-08-15
SE8500368L (en) 1985-07-26
DE3502508A1 (en) 1985-08-14
ES8609309A1 (en) 1986-07-16
AT392276B (en) 1991-02-25
GB2153821A (en) 1985-08-29
PT79890A (en) 1985-02-01
CY1479A (en) 1989-07-21
SG7089G (en) 1989-06-09
SK404391A3 (en) 1995-08-09
IT1182150B (en) 1987-09-30
BE901576A (en) 1985-07-25
HU193592B (en) 1987-11-30
ES539852A0 (en) 1986-07-16
GB2153821B (en) 1988-01-20
FI850323A0 (en) 1985-01-25
NL8500202A (en) 1985-08-16
IE57809B1 (en) 1993-04-21
KR920003064B1 (en) 1992-04-13
IL74165A (en) 1988-11-15
NL940009I1 (en) 1994-07-18
CZ404391A3 (en) 1993-04-14
IT8547600A0 (en) 1985-01-25
DK169521B1 (en) 1994-11-21
ES556101A0 (en) 1987-12-16
NZ210940A (en) 1989-08-29
IE850187L (en) 1985-07-25
NL190373B (en) 1993-09-01
PT79890B (en) 1987-02-03
DK35785D0 (en) 1985-01-25
FI84349C (en) 1991-11-25
FI84349B (en) 1991-08-15
CA1252793A (en) 1989-04-18
LU88268I2 (en) 1994-02-03
ES8801247A1 (en) 1987-12-16
NO1994022I1 (en) 1994-11-09
LU85743A1 (en) 1986-08-04
GB8501889D0 (en) 1985-02-27
AU3809785A (en) 1985-08-01
KR850005439A (en) 1985-08-26
SK277923B6 (en) 1995-08-09
ES8708224A1 (en) 1987-10-01
SE460359B (en) 1989-10-02
HK33189A (en) 1989-04-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070630