[go: up one dir, main page]

ES537994A0 - Un metodo de producir una proteina de interleuquina-2-humana no glicosilada sustancialmente pura - Google Patents

Un metodo de producir una proteina de interleuquina-2-humana no glicosilada sustancialmente pura

Info

Publication number
ES537994A0
ES537994A0 ES537994A ES537994A ES537994A0 ES 537994 A0 ES537994 A0 ES 537994A0 ES 537994 A ES537994 A ES 537994A ES 537994 A ES537994 A ES 537994A ES 537994 A0 ES537994 A0 ES 537994A0
Authority
ES
Spain
Prior art keywords
producing
substantially pure
human protein
pure non
glycosylated interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES537994A
Other languages
English (en)
Other versions
ES8606489A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16823684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES537994(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8606489A1 publication Critical patent/ES8606489A1/es
Publication of ES537994A0 publication Critical patent/ES537994A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES537994A 1983-11-28 1984-11-27 Un metodo de producir una proteina de interleuquina-2-humana no glicosilada sustancialmente pura Expired ES8606489A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58225079A JPS60115528A (ja) 1983-11-28 1983-11-28 ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物

Publications (2)

Publication Number Publication Date
ES8606489A1 ES8606489A1 (es) 1986-04-01
ES537994A0 true ES537994A0 (es) 1986-04-01

Family

ID=16823684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537994A Expired ES8606489A1 (es) 1983-11-28 1984-11-27 Un metodo de producir una proteina de interleuquina-2-humana no glicosilada sustancialmente pura

Country Status (16)

Country Link
US (1) US5464939A (es)
EP (3) EP0751220A1 (es)
JP (1) JPS60115528A (es)
KR (1) KR920006879B1 (es)
DK (1) DK164174C (es)
ES (1) ES8606489A1 (es)
FI (1) FI81118C (es)
GR (1) GR81040B (es)
HU (1) HU200793B (es)
IL (1) IL73530A0 (es)
MY (1) MY103892A (es)
NO (1) NO169021C (es)
NZ (1) NZ210352A (es)
PT (1) PT79555B (es)
SG (1) SG46452A1 (es)
ZA (1) ZA849221B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
DK174501B1 (da) * 1983-12-23 2003-04-28 Hoffmann La Roche Fremgangsmåde til fremstilling af interleukin-2
JPS60243021A (ja) * 1984-03-28 1985-12-03 シタス　コ−ポレイシヨン システイン含有蛋白質の制御された酸化方法
US4569790A (en) 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
US4908433A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−２の製造方法
WO1986007093A1 (fr) * 1985-05-29 1986-12-04 The Green Cross Corporation Procede de preparation d'une proteine heterogene
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3581412D1 (de) * 1985-07-16 1991-02-21 Green Cross Corp Verfahren zur herstellung von heteroproteinen.
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
CN86104525A (zh) * 1985-07-31 1987-02-25 武田药品工业株式会社 人类白细胞介素-2的分析方法和试剂
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
JPH0655153B2 (ja) * 1986-02-26 1994-07-27 武田薬品工業株式会社 ヒトインターロイキン―２結晶の製造法
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
US5149788A (en) * 1987-05-19 1992-09-22 Hoffmann-La Roche, Inc. Purification of chimeric proteins containing an IL-2 moiety by receptor-affinity chromatography
US5162503A (en) * 1987-05-19 1992-11-10 Hoffmann-La Roche, Inc. Purification of interleukin-2 by receptor-affinity chromatography
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US5250296A (en) * 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP1803730A1 (en) 2000-04-12 2007-07-04 Human Genome Sciences, Inc. Albumin fusion proteins
EP2277910A1 (en) 2001-12-21 2011-01-26 Human Genome Sciences, Inc. Albumin fusion proteins
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
GB201000693D0 (en) 2010-01-15 2010-03-03 Isis Innovation A solar cell
MX388465B (es) * 2010-11-12 2025-03-20 Nektar Therapeutics Conjugados de un resto de interleucina-2 y un polímero.
JP6941561B2 (ja) 2014-10-09 2021-09-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Ｉｌ‐２をコードする新規伝令ｒｎａの製造法
JPH0751511B2 (ja) * 1982-03-15 1995-06-05 味の素株式会社 インターロイキン２を含有してなる癌治療剤
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
JPS58201979A (ja) * 1982-05-18 1983-11-25 Japan Found Cancer ヒトインタ−ロイキン２遺伝子が組込まれているエシエリヒア・コリおよびその育種方法
JPS58168492A (ja) * 1982-03-31 1983-10-04 Nippon Kokan Kk <Nkk> パイプ切断機
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
NL8203321A (nl) * 1982-08-25 1984-03-16 Philips Nv Kleurenbeeldbuis.
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
ZA842025B (en) * 1983-03-21 1984-11-28 Hoffmann La Roche Interleuken-2
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
EP0162898A4 (en) * 1983-11-14 1987-07-23 Chiron Corp INTERLEUKIN-2 GENERATION USING CLONED GENES FOR INTERLEUKIN-2 AND YEAR ALPHA FACTOR.
DK174501B1 (da) * 1983-12-23 2003-04-28 Hoffmann La Roche Fremgangsmåde til fremstilling af interleukin-2
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
JP2608730B2 (ja) * 1987-08-10 1997-05-14 株式会社リコー 感熱記録材料

Also Published As

Publication number Publication date
KR920006879B1 (ko) 1992-08-21
GR81040B (en) 1985-03-27
KR850003734A (ko) 1985-06-26
HUT36186A (en) 1985-08-28
FI844678L (fi) 1985-05-29
NZ210352A (en) 1988-11-29
NO169021C (no) 1992-04-29
AU3575684A (en) 1985-06-06
JPS60115528A (ja) 1985-06-22
HU200793B (en) 1990-08-28
FI844678A0 (fi) 1984-11-28
DK560784D0 (da) 1984-11-27
NO844710L (no) 1985-05-29
IL73530A0 (en) 1985-02-28
DK164174C (da) 1992-10-05
EP0145390A2 (en) 1985-06-19
ES8606489A1 (es) 1986-04-01
EP0751220A1 (en) 1997-01-02
EP0442538A1 (en) 1991-08-21
DK164174B (da) 1992-05-18
ZA849221B (en) 1986-07-30
SG46452A1 (en) 1998-02-20
PT79555A (en) 1984-12-01
FI81118B (fi) 1990-05-31
DK560784A (da) 1985-05-29
NO169021B (no) 1992-01-20
AU592527B2 (en) 1990-01-18
FI81118C (fi) 1990-09-10
JPH0542413B2 (es) 1993-06-28
MY103892A (en) 1993-10-30
US5464939A (en) 1995-11-07
EP0145390A3 (en) 1987-01-21
PT79555B (en) 1986-12-15

Similar Documents

Publication Publication Date Title
ES537994A0 (es) Un metodo de producir una proteina de interleuquina-2-humana no glicosilada sustancialmente pura
ES542028A0 (es) Un metodo de producir una composicion de interleuquina-2
ES535511A0 (es) Un metodo para producir una proteina heterologa madura.
DE3466381D1 (en) Method of producing ceramic parts
ES527414A0 (es) Un metodo de producir una proteina interferon inmune humano
ES531557A0 (es) Un metodo de producir l-carnitina
KR900009238A (ko) 장식품의 제조 방법
ES537330A0 (es) Un procedimiento para producir un peptido que comprende un peptido de exo-senal unido operativamente a una proteina deseada
ES541572A0 (es) Un metodo de fabricar una camisa de valvula
KR900009790A (ko) 모노-n-알킬화된 폴리아자마크로사이클의 제조방법
ES532509A0 (es) Un metodo de preparar dihidrobenzopirrolbenzodiazepinas
ES530248A0 (es) Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos
IT1174195B (it) Albero a camme e procentimento per la sua fabbricazione
IT8448880A0 (it) Rine procedimento per produrre cefalospo
IT1178858B (it) Procedimento per la produzione di triptofano
TR21940A (tr) Alkol ueretme yoentemleri
ES520029A0 (es) Metodo de producir ferrosilicio.
IT1177343B (it) Procedimento per produrre 4-alcossianiline
ES530184A0 (es) Metodo de producir una preparacion yodofora farmaceutica
ES540907A0 (es) Un metodo de producir una composicion farmaceutica estabili-zada
ES528119A0 (es) Un metodo de produccion de una preparacion de proteina a-igg
RO90519A (ro) Procedeu de preparare a clorotioformiatilor
ES529348A0 (es) Metodo de fabricacion de cierres de cremallera
KR900010983A (ko) 리드 프레임의 제조방법
ES534261A0 (es) Un metodo de produccion de una composicion de aclarrubicina o hidrocloruro de aclarrubicina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401